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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRDX1 |
 Gene summary |
| Gene information | Gene symbol | PRDX1 | Gene ID | 5052 |
| Gene name | peroxiredoxin 1 | |
| Synonyms | MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2 | |
| Cytomap | 1p34.1 | |
| Type of gene | protein-coding | |
| Description | peroxiredoxin-1epididymis secretory sperm binding proteinnatural killer cell-enhancing factor Anatural killer-enhancing factor Aproliferation-associated gene Aproliferation-associated gene proteinthioredoxin peroxidase 2thioredoxin-dependent peroxi | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 21674491(Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRDX1 | GO:0030101 | natural killer cell activation | 8462106 |
| PRDX1 | GO:0042744 | hydrogen peroxide catabolic process | 11986303|18606987 |
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Gene structures and expression levels for PRDX1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000117450
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000447184.5 | PRDX1-205:protein_coding:PRDX1 | 5.957208e+00 | 3.382766e+00 | 5.625917e-04 | 9.587048e-03 |
| CB | UP | ENST00000483583.1 | PRDX1-206:lncRNA:PRDX1 | 1.618972e+01 | 1.515895e+00 | 4.640895e-04 | 2.704470e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRDX1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_27829 | chr1 | 45514873:45514995:45515654:45515807:45518938:45518947 | 45515654:45515807 |
| exon_skip_41119 | chr1 | 45514507:45514637:45514873:45514995:45515654:45515807 | 45514873:45514995 |
| exon_skip_56958 | chr1 | 45514873:45514995:45515654:45515807:45518938:45519047 | 45515654:45515807 |
| exon_skip_63478 | chr1 | 45511051:45511414:45514507:45514637:45514873:45514895 | 45514507:45514637 |
| exon_skip_89670 | chr1 | 45515654:45515807:45518938:45519054:45521829:45521854 | 45518938:45519054 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PRDX1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319248 | 45518938 | 45519054 | 3UTR-3CDS |
| ENST00000262746 | 45514507 | 45514637 | Frame-shift |
| ENST00000319248 | 45514507 | 45514637 | Frame-shift |
| ENST00000262746 | 45515654 | 45515807 | Frame-shift |
| ENST00000319248 | 45515654 | 45515807 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262746 | 45515654 | 45515807 | Frame-shift |
| ENST00000319248 | 45515654 | 45515807 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319248 | 45518938 | 45519054 | 3UTR-3CDS |
| ENST00000262746 | 45514507 | 45514637 | Frame-shift |
| ENST00000319248 | 45514507 | 45514637 | Frame-shift |
| ENST00000262746 | 45515654 | 45515807 | Frame-shift |
| ENST00000319248 | 45515654 | 45515807 | Frame-shift |
| ENST00000262746 | 45514873 | 45514995 | In-frame |
| ENST00000319248 | 45514873 | 45514995 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PRDX1 |
p-ENSG00000117450_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262746 | 1251 | 199 | 45514873 | 45514995 | 602 | 723 | 87 | 127 |
| ENST00000319248 | 1038 | 199 | 45514873 | 45514995 | 400 | 521 | 87 | 127 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q06830 | 87 | 127 | 104 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 104 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 124 | 126 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 124 | 126 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 2 | 199 | Chain | ID=PRO_0000135076;Note=Peroxiredoxin-1 |
| Q06830 | 87 | 127 | 2 | 199 | Chain | ID=PRO_0000135076;Note=Peroxiredoxin-1 |
| Q06830 | 87 | 127 | 120 | 120 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q06830 | 87 | 127 | 120 | 120 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q06830 | 87 | 127 | 6 | 165 | Domain | Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 |
| Q06830 | 87 | 127 | 6 | 165 | Domain | Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 |
| Q06830 | 87 | 127 | 81 | 88 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 81 | 88 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 92 | 94 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 92 | 94 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 111 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 111 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 90 | 90 | Modified residue | Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 90 | 90 | Modified residue | Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 90 | 90 | Mutagenesis | Note=Abolishes phosphorylation by CDK1%3B 30%25 reduction in enzymatic activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 90 | 90 | Mutagenesis | Note=Abolishes phosphorylation by CDK1%3B 30%25 reduction in enzymatic activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 90 | 90 | Mutagenesis | Note=87%25 reduction in enzymatic activity. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 90 | 90 | Mutagenesis | Note=87%25 reduction in enzymatic activity. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11986303;Dbxref=PMID:11986303 |
| Q06830 | 87 | 127 | 121 | 123 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
| Q06830 | 87 | 127 | 121 | 123 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HY2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRDX1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRDX1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRDX1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRDX1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PRDX1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PRDX1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q06830 | approved|investigational | DB01593 | Zinc | small molecule | Q06830 |
| Q06830 | approved|investigational | DB14487 | Zinc acetate | small molecule | Q06830 |
| Q06830 | approved|investigational | DB14533 | Zinc chloride | small molecule | Q06830 |
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RelatedDiseases for PRDX1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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