|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for OAS3 |
Gene summary |
Gene information | Gene symbol | OAS3 | Gene ID | 4940 |
Gene name | 2'-5'-oligoadenylate synthetase 3 | |
Synonyms | p100|p100OAS | |
Cytomap | 12q24.13 | |
Type of gene | protein-coding | |
Description | 2'-5'-oligoadenylate synthase 3(2-5')oligo(A) synthase 3(2-5')oligo(A) synthetase 32'-5'-oligoadenylate synthetase 3, 100kDa2'-5'oligoadenylate synthetase p1002-5A synthase 32-5A synthetase 3p100 OAS | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
OAS3 | GO:0009615 | response to virus | 19056102 |
OAS3 | GO:0045071 | negative regulation of viral genome replication | 19056102|19923450 |
OAS3 | GO:0051607 | defense response to virus | 19923450 |
OAS3 | GO:0060700 | regulation of ribonuclease activity | 19923450 |
Top |
Gene structures and expression levels for OAS3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for OAS3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_111360 | chr12 | 112947946:112948099:112948861:112949205:112950693:112950975 | 112948861:112949205 |
exon_skip_137609 | chr12 | 112938546:112938707:112941570:112941852:112944476:112944651 | 112941570:112941852 |
exon_skip_91856 | chr12 | 112941570:112941852:112944476:112944651:112946743:112946979 | 112944476:112944651 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for OAS3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000228928 | 112944476 | 112944651 | Frame-shift |
ENST00000228928 | 112948861 | 112949205 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000228928 | 112941570 | 112941852 | Frame-shift |
ENST00000228928 | 112948861 | 112949205 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for OAS3 |
p-ENSG00000111331_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000228928 | 6736 | 1087 | 112948861 | 112949205 | 1210 | 1553 | 343 | 458 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000228928 | 6736 | 1087 | 112948861 | 112949205 | 1210 | 1553 | 343 | 458 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y6K5 | 343 | 458 | 1 | 1087 | Chain | ID=PRO_0000160265;Note=2'-5'-oligoadenylate synthase 3 |
Q9Y6K5 | 343 | 458 | 365 | 365 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
Q9Y6K5 | 343 | 458 | 378 | 378 | Natural variant | ID=VAR_062127;Note=R->K;Dbxref=dbSNP:rs45519442 |
Q9Y6K5 | 343 | 458 | 381 | 381 | Natural variant | ID=VAR_057661;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2285933,PMID:15489334 |
Q9Y6K5 | 343 | 458 | 6 | 343 | Region | Note=OAS domain 1;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 344 | 410 | Region | Note=Linker;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 411 | 742 | Region | Note=OAS domain 2;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 393 | 393 | Sequence conflict | Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y6K5 | 343 | 458 | 1 | 1087 | Chain | ID=PRO_0000160265;Note=2'-5'-oligoadenylate synthase 3 |
Q9Y6K5 | 343 | 458 | 365 | 365 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
Q9Y6K5 | 343 | 458 | 378 | 378 | Natural variant | ID=VAR_062127;Note=R->K;Dbxref=dbSNP:rs45519442 |
Q9Y6K5 | 343 | 458 | 381 | 381 | Natural variant | ID=VAR_057661;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2285933,PMID:15489334 |
Q9Y6K5 | 343 | 458 | 6 | 343 | Region | Note=OAS domain 1;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 344 | 410 | Region | Note=Linker;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 411 | 742 | Region | Note=OAS domain 2;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9Y6K5 | 343 | 458 | 393 | 393 | Sequence conflict | Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in OAS3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for OAS3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for OAS3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OAS3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for OAS3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for OAS3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for OAS3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |