ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for NRCAM

Gene summary

Gene information	Gene symbol	NRCAM
	Gene ID	4897
	Gene name	neuronal cell adhesion molecule
	Synonyms	-
	Cytomap	7q31.1
	Type of gene	protein-coding
	Description	neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo
	Modification date	20200313
	UniProtAcc	A0A087X2B3, A0A1B1PFW4, A0A1S5UZH4, C9J8B6, C9JF43, C9JH43, C9JUR7, C9JYY6, F8W775, H7C132, Q14CA1, Q4KMQ7, Q6QRP2, Q75ML9, Q92823,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NRCAM	GO:0045162	clustering of voltage-gated sodium channels	14602817

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Gene structures and expression levels for NRCAM

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000091129

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
HCC	UP	ENST00000522550.2	NRCAM-216:lncRNA:NRCAM	1.687156e+02	2.837947e+00	6.944982e-18	7.492864e-14
STG	UP	ENST00000379022.8	NRCAM-202:protein_coding:NRCAM	5.819921e+01	5.896349e+00	1.089243e-03	4.032822e-02
CB	UP	ENST00000379024.8	NRCAM-203:protein_coding:NRCAM	5.844165e+02	8.307828e-01	7.799810e-04	4.193401e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NRCAM

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_102992	chr7	108166921:108167073:108168277:108168402:108175322:108175357	108168277:108168402
exon_skip_104192	chr7	108160361:108160492:108176430:108176606:108177990:108178112	108176430:108176606
exon_skip_105918	chr7	108176430:108176606:108177990:108178112:108180223:108180427	108177990:108178112
exon_skip_10628	chr7	108234630:108234688:108237752:108237769:108239959:108240049	108237752:108237769
exon_skip_130763	chr7	108168277:108168402:108175322:108175357:108176430:108176480	108175322:108175357
exon_skip_17068	chr7	108312665:108312731:108399436:108399593:108456243:108456321	108399436:108399593
exon_skip_173376	chr7	108237752:108237769:108239959:108240170:108312665:108312731	108239959:108240170
exon_skip_175590	chr7	108223725:108223836:108225645:108225701:108226208:108226378	108225645:108225701
exon_skip_187961	chr7	108160361:108160492:108175322:108175357:108176430:108176606	108175322:108175357
exon_skip_193003	chr7	108184417:108184614:108189645:108189746:108191254:108191283	108189645:108189746
exon_skip_211656	chr7	108207528:108207659:108209421:108209605:108223725:108223836	108209421:108209605
exon_skip_213257	chr7	108160361:108160492:108168277:108168402:108175322:108175333	108168277:108168402
exon_skip_232091	chr7	108189645:108189746:108191254:108191283:108191729:108191853	108191254:108191283
exon_skip_232516	chr7	108159463:108159541:108160361:108160492:108176430:108176606	108160361:108160492
exon_skip_235993	chr7	108234630:108234688:108239959:108240170:108312665:108312731	108239959:108240170
exon_skip_245764	chr7	108160361:108160492:108175322:108175357:108176430:108176477	108175322:108175357
exon_skip_248175	chr7	108160361:108160492:108166921:108167073:108168277:108168402	108166921:108167073
exon_skip_249663	chr7	108168277:108168402:108175322:108175357:108176430:108176606	108175322:108175357
exon_skip_279111	chr7	108160361:108160492:108176430:108176606:108177990:108178105	108176430:108176606
exon_skip_280188	chr7	108234630:108234688:108237752:108237769:108239959:108239984	108237752:108237769
exon_skip_40973	chr7	108231031:108231153:108232326:108232522:108234583:108234688	108232326:108232522
exon_skip_51277	chr7	108160373:108160492:108175322:108175357:108176430:108176606	108175322:108175357
exon_skip_61154	chr7	108166921:108167073:108168277:108168402:108175322:108175333	108168277:108168402
exon_skip_6480	chr7	108239959:108240170:108312665:108312731:108399436:108399593	108312665:108312731
exon_skip_65447	chr7	108160361:108160492:108175322:108175357:108176430:108176480	108175322:108175357
exon_skip_860	chr7	108195761:108195872:108197956:108198099:108207528:108207659	108197956:108198099
exon_skip_94501	chr7	108160373:108160492:108166921:108167073:108168277:108168402	108166921:108167073

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_65447	MSBB_STG	5.244776e-01	6.866667e-01	-1.621891e-01	1.039747e-02
exon_skip_232091	MSBB_STG	5.549275e-01	7.008333e-01	-1.459058e-01	5.998152e-03
exon_skip_280188	MSBB_STG	6.589855e-01	7.741667e-01	-1.151812e-01	1.188328e-02
exon_skip_64653	MSBB_PG	2.109524e-01	3.467241e-01	-1.357718e-01	5.707744e-05
exon_skip_51277	MSBB_PG	3.263265e-01	5.377586e-01	-2.114321e-01	4.619132e-06
exon_skip_232091	MSBB_PG	4.456250e-01	6.284483e-01	-1.828233e-01	1.253328e-05
exon_skip_175590	MSBB_PG	6.583333e-01	5.010345e-01	1.572989e-01	7.165362e-07
exon_skip_10628	MSBB_PG	5.392053e-01	6.972414e-01	-1.580361e-01	8.151588e-07
exon_skip_175590	MSBB_IFG	5.200000e-01	4.136364e-01	1.063636e-01	3.527962e-02
exon_skip_102452	Mayo_TC	2.322500e-01	3.687097e-01	-1.364597e-01	2.124702e-05
exon_skip_65447	Mayo_TC	2.730488e-01	4.061972e-01	-1.331484e-01	2.072300e-04
exon_skip_232091	Mayo_TC	2.660976e-01	4.114085e-01	-1.453109e-01	1.416422e-04
exon_skip_10628	Mayo_TC	2.924390e-01	4.675714e-01	-1.751324e-01	5.767995e-06

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Open reading frame (ORF) annotation in the exon skipping event for NRCAM

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000379028	108239959	108240170	3UTR-3CDS
ENST00000379028	108399436	108399593	3UTR-3UTR
ENST00000379028	108209421	108209605	Frame-shift
ENST00000425651	108209421	108209605	Frame-shift
ENST00000379028	108232326	108232522	Frame-shift
ENST00000425651	108232326	108232522	Frame-shift
ENST00000379028	108166921	108167073	In-frame
ENST00000425651	108166921	108167073	In-frame
ENST00000379028	108168277	108168402	In-frame
ENST00000425651	108168277	108168402	In-frame
ENST00000379028	108175322	108175357	In-frame
ENST00000425651	108175322	108175357	In-frame
ENST00000379028	108177990	108178112	In-frame
ENST00000425651	108177990	108178112	In-frame
ENST00000379028	108191254	108191283	In-frame
ENST00000425651	108191254	108191283	In-frame
ENST00000379028	108197956	108198099	In-frame
ENST00000425651	108197956	108198099	In-frame
ENST00000379028	108225645	108225701	In-frame
ENST00000425651	108225645	108225701	In-frame
ENST00000379028	108237752	108237769	In-frame
ENST00000425651	108237752	108237769	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000379028	108239959	108240170	3UTR-3CDS
ENST00000379028	108399436	108399593	3UTR-3UTR
ENST00000379028	108209421	108209605	Frame-shift
ENST00000425651	108209421	108209605	Frame-shift
ENST00000379028	108166921	108167073	In-frame
ENST00000425651	108166921	108167073	In-frame
ENST00000379028	108168277	108168402	In-frame
ENST00000425651	108168277	108168402	In-frame
ENST00000379028	108175322	108175357	In-frame
ENST00000425651	108175322	108175357	In-frame
ENST00000379028	108191254	108191283	In-frame
ENST00000425651	108191254	108191283	In-frame
ENST00000379028	108225645	108225701	In-frame
ENST00000425651	108225645	108225701	In-frame
ENST00000379028	108237752	108237769	In-frame
ENST00000425651	108237752	108237769	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000379028	108239959	108240170	3UTR-3CDS
ENST00000379028	108312665	108312731	3UTR-3UTR
ENST00000379028	108399436	108399593	3UTR-3UTR
ENST00000379028	108209421	108209605	Frame-shift
ENST00000425651	108209421	108209605	Frame-shift
ENST00000379028	108232326	108232522	Frame-shift
ENST00000425651	108232326	108232522	Frame-shift
ENST00000379028	108166921	108167073	In-frame
ENST00000425651	108166921	108167073	In-frame
ENST00000379028	108168277	108168402	In-frame
ENST00000425651	108168277	108168402	In-frame
ENST00000379028	108175322	108175357	In-frame
ENST00000425651	108175322	108175357	In-frame
ENST00000379028	108189645	108189746	In-frame
ENST00000425651	108189645	108189746	In-frame
ENST00000379028	108191254	108191283	In-frame
ENST00000425651	108191254	108191283	In-frame
ENST00000379028	108197956	108198099	In-frame
ENST00000425651	108197956	108198099	In-frame
ENST00000379028	108225645	108225701	In-frame
ENST00000425651	108225645	108225701	In-frame
ENST00000379028	108237752	108237769	In-frame
ENST00000425651	108237752	108237769	In-frame

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Infer the effects of exon skipping event on protein functional features for NRCAM

p-ENSG00000091129_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000379028	6702	1304	108225645	108225701	1208	1263	240	259
ENST00000425651	3932	1304	108225645	108225701	722	777	240	259
ENST00000379028	6702	1304	108197956	108198099	1694	1836	402	450
ENST00000425651	3932	1304	108197956	108198099	1208	1350	402	450
ENST00000379028	6702	1304	108191254	108191283	2390	2418	634	644
ENST00000425651	3932	1304	108191254	108191283	1904	1932	634	644
ENST00000379028	6702	1304	108177990	108178112	3338	3459	950	991
ENST00000425651	3932	1304	108177990	108178112	2852	2973	950	991
ENST00000379028	6702	1304	108175322	108175357	3638	3672	1050	1062
ENST00000425651	3932	1304	108175322	108175357	3152	3186	1050	1062
ENST00000379028	6702	1304	108168277	108168402	3674	3798	1062	1104
ENST00000425651	3932	1304	108168277	108168402	3188	3312	1062	1104
ENST00000379028	6702	1304	108166921	108167073	3800	3951	1104	1155
ENST00000425651	3932	1304	108166921	108167073	3314	3465	1104	1155

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000379028	6702	1304	108225645	108225701	1208	1263	240	259
ENST00000425651	3932	1304	108225645	108225701	722	777	240	259
ENST00000379028	6702	1304	108191254	108191283	2390	2418	634	644
ENST00000425651	3932	1304	108191254	108191283	1904	1932	634	644
ENST00000379028	6702	1304	108175322	108175357	3638	3672	1050	1062
ENST00000425651	3932	1304	108175322	108175357	3152	3186	1050	1062
ENST00000379028	6702	1304	108168277	108168402	3674	3798	1062	1104
ENST00000425651	3932	1304	108168277	108168402	3188	3312	1062	1104
ENST00000379028	6702	1304	108166921	108167073	3800	3951	1104	1155
ENST00000425651	3932	1304	108166921	108167073	3314	3465	1104	1155

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000379028	6702	1304	108225645	108225701	1208	1263	240	259
ENST00000425651	3932	1304	108225645	108225701	722	777	240	259
ENST00000379028	6702	1304	108197956	108198099	1694	1836	402	450
ENST00000425651	3932	1304	108197956	108198099	1208	1350	402	450
ENST00000379028	6702	1304	108191254	108191283	2390	2418	634	644
ENST00000425651	3932	1304	108191254	108191283	1904	1932	634	644
ENST00000379028	6702	1304	108189645	108189746	2420	2520	644	678
ENST00000425651	3932	1304	108189645	108189746	1934	2034	644	678
ENST00000379028	6702	1304	108175322	108175357	3638	3672	1050	1062
ENST00000425651	3932	1304	108175322	108175357	3152	3186	1050	1062
ENST00000379028	6702	1304	108168277	108168402	3674	3798	1062	1104
ENST00000425651	3932	1304	108168277	108168402	3188	3312	1062	1104
ENST00000379028	6702	1304	108166921	108167073	3800	3951	1104	1155
ENST00000425651	3932	1304	108166921	108167073	3314	3465	1104	1155

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q92823	402	450	361	448	Domain	Note=Ig-like 4
Q92823	402	450	361	448	Domain	Note=Ig-like 4
Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	950	991	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	950	991	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	950	991	848	950	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	950	991	848	950	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	950	991	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	950	991	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	950	991	954	954	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	950	991	954	954	Sequence conflict	Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	950	991	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	950	991	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	241	259	Alternative sequence	ID=VSP_007838;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:9205841;Dbxref=PMID:15489334,PMID:9205841
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	245	245	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	251	251	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	240	259	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	402	450	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q92823	402	450	382	432	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q92823	402	450	361	448	Domain	Note=Ig-like 4
Q92823	402	450	361	448	Domain	Note=Ig-like 4
Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	433	433	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	402	450	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	634	644	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	644	678	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	644	678	635	644	Alternative sequence	ID=VSP_007839;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q92823	644	678	651	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	651	656	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	659	661	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	659	661	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	663	668	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	663	668	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	677	686	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	677	686	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1UEY
Q92823	644	678	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	644	678	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	644	678	649	744	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	644	678	649	744	Domain	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	644	678	651	651	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	644	678	651	651	Sequence conflict	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	644	678	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	644	678	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	954	1051	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1050	1062	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1072	1072	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1083	1083	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1093	1093	Natural variant	ID=VAR_035528;Note=In a breast cancer sample%3B somatic mutation. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1068	1068	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	1093	1094	Sequence conflict	Note=HV->YA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1062	1104	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1051	1155	Alternative sequence	ID=VSP_007840;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:17974005,ECO:0000303\|PubMed:9205841;Dbxref=PMID:17974005,PMID:9205841
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	1063	1155	Alternative sequence	ID=VSP_045040;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	25	1304	Chain	ID=PRO_0000015057;Note=Neuronal cell adhesion molecule
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1064	1156	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1115	1115	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1116	1116	Natural variant	ID=VAR_035529;Note=In a breast cancer sample%3B somatic mutation. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1134	1134	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1141	1143	Sequence conflict	Note=DSG->GPR;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	1149	1149	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q92823	1104	1155	25	1167	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

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3'-UTR located exon skipping events that lost miRNA binding sites in NRCAM

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000379028	108312665	108312731	hsa-miR-186-5p	chr7:108312699-108312706	8mer-1a	chr7:108312685-108312706	145.00	-7.01
Mayo	ENST00000379028	108399436	108399593	hsa-miR-758-3p	chr7:108399581-108399588	8mer-1a	chr7:108399567-108399591	145.00	-12.81
Mayo	ENST00000379028	108399436	108399593	hsa-miR-4310	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
Mayo	ENST00000379028	108399436	108399593	hsa-miR-1273h-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-6779-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-6780a-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-4324	chr7:108399500-108399507	8mer-1a	chr7:108399487-108399508	140.00	-18.68
Mayo	ENST00000379028	108399436	108399593	hsa-miR-6799-5p	chr7:108399461-108399468	8mer-1a	chr7:108399449-108399468	154.00	-25.74
Mayo	ENST00000379028	108399436	108399593	hsa-miR-7157-5p	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
Mayo	ENST00000379028	108399436	108399593	hsa-miR-7110-3p	chr7:108399571-108399578	8mer-1a	chr7:108399556-108399579	160.00	-18.41
Mayo	ENST00000379028	108399436	108399593	hsa-miR-887-5p	chr7:108399463-108399470	8mer-1a	chr7:108399458-108399483	148.00	-19.00
Mayo	ENST00000379028	108399436	108399593	hsa-miR-6873-3p	chr7:108399572-108399579	8mer-1a	chr7:108399556-108399579	160.00	-18.41
Mayo	ENST00000379028	108399436	108399593	hsa-miR-30b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-3689c	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-3689a-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
Mayo	ENST00000379028	108399436	108399593	hsa-miR-3689b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-758-3p	chr7:108399581-108399588	8mer-1a	chr7:108399567-108399591	145.00	-12.81
MSBB	ENST00000379028	108399436	108399593	hsa-miR-4310	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
MSBB	ENST00000379028	108399436	108399593	hsa-miR-1273h-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-6779-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-6780a-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-4324	chr7:108399500-108399507	8mer-1a	chr7:108399487-108399508	140.00	-18.68
MSBB	ENST00000379028	108399436	108399593	hsa-miR-6799-5p	chr7:108399461-108399468	8mer-1a	chr7:108399449-108399468	154.00	-25.74
MSBB	ENST00000379028	108399436	108399593	hsa-miR-7157-5p	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
MSBB	ENST00000379028	108399436	108399593	hsa-miR-7110-3p	chr7:108399571-108399578	8mer-1a	chr7:108399556-108399579	160.00	-18.41
MSBB	ENST00000379028	108399436	108399593	hsa-miR-887-5p	chr7:108399463-108399470	8mer-1a	chr7:108399458-108399483	148.00	-19.00
MSBB	ENST00000379028	108399436	108399593	hsa-miR-6873-3p	chr7:108399572-108399579	8mer-1a	chr7:108399556-108399579	160.00	-18.41
MSBB	ENST00000379028	108399436	108399593	hsa-miR-30b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-3689c	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-3689a-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
MSBB	ENST00000379028	108399436	108399593	hsa-miR-3689b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-758-3p	chr7:108399581-108399588	8mer-1a	chr7:108399567-108399591	145.00	-12.81
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-4310	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-1273h-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-6779-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-6780a-5p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-4324	chr7:108399500-108399507	8mer-1a	chr7:108399487-108399508	140.00	-18.68
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-6799-5p	chr7:108399461-108399468	8mer-1a	chr7:108399449-108399468	154.00	-25.74
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-7157-5p	chr7:108399565-108399572	8mer-1a	chr7:108399550-108399572	164.00	-18.92
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-7110-3p	chr7:108399571-108399578	8mer-1a	chr7:108399556-108399579	160.00	-18.41
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-887-5p	chr7:108399463-108399470	8mer-1a	chr7:108399458-108399483	148.00	-19.00
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-6873-3p	chr7:108399572-108399579	8mer-1a	chr7:108399556-108399579	160.00	-18.41
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-30b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-3689c	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-3689a-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16
ROSMAP	ENST00000379028	108399436	108399593	hsa-miR-3689b-3p	chr7:108399462-108399469	8mer-1a	chr7:108399448-108399469	155.00	-23.16

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SNVs in the skipped exons for NRCAM

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for NRCAM

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_175590	4.720986e-01	1.119639e-02	chr7	-	108223725	108223836	108225645	108225701	108226208	108226378
ADstage	MSBB	IFG	exon_skip_275892	-4.502892e-01	1.619530e-02	chr7	-	108234630	108234688	108237752	108237781	108239959	108240049
ADstage	MSBB	PG	exon_skip_10628	-3.867042e-01	7.310000e-09	chr7	-	108234630	108234688	108237752	108237769	108239959	108240049
CDR	MSBB	IFG	exon_skip_275892	-5.474503e-01	2.568181e-03	chr7	-	108234630	108234688	108237752	108237781	108239959	108240049
CDR	MSBB	IFG	exon_skip_175590	4.612874e-01	1.348335e-02	chr7	-	108223725	108223836	108225645	108225701	108226208	108226378
CDR	MSBB	IFG	exon_skip_10628	-4.321771e-01	2.163483e-02	chr7	-	108234630	108234688	108237752	108237769	108239959	108240049
CDR	MSBB	IFG	exon_skip_232091	-4.113055e-01	2.966981e-02	chr7	-	108189645	108189746	108191254	108191283	108191729	108191853
CDR	MSBB	IFG	exon_skip_279362	-3.829955e-01	4.425471e-02	chr7	-	108160361	108160492	108175322	108175333	108176430	108176606
CDR	MSBB	IFG	exon_skip_151030	-3.789065e-01	4.676508e-02	chr7	-	108312665	108312731	108313972	108314052	108399436	108399593
CDR	MSBB	PG	exon_skip_10628	-3.675489e-01	4.390000e-08	chr7	-	108234630	108234688	108237752	108237769	108239959	108240049
CDR	MSBB	STG	exon_skip_232091	-3.910702e-01	1.062390e-04	chr7	-	108189645	108189746	108191254	108191283	108191729	108191853
CDR	MSBB	STG	exon_skip_280188	-3.489219e-01	6.085660e-04	chr7	-	108234630	108234688	108237752	108237769	108239959	108239984
CDR	MSBB	STG	exon_skip_198894	-3.237929e-01	1.545153e-03	chr7	-	108150049	108150147	108156387	108156448	108159463	108159535

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRCAM

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for NRCAM

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	PABPN1	exon_skip_110144	4.232270e-01	4.282868e-07
CB	ELAVL1	exon_skip_110144	4.299490e-01	2.675892e-07
CB	ZNF638	exon_skip_110144	4.630602e-01	2.261403e-08
CB	CNOT4	exon_skip_110144	5.592771e-01	3.164705e-12
CB	PCBP1	exon_skip_110144	4.105664e-01	1.010749e-06
CB	TRA2A	exon_skip_110144	4.571440e-01	3.585613e-08
CB	FUBP1	exon_skip_110144	4.782775e-01	6.632762e-09
CB	KHSRP	exon_skip_110144	4.580369e-01	3.346519e-08
CB	SRSF1	exon_skip_110144	4.540823e-01	4.536115e-08
CB	RBFOX2	exon_skip_168360	4.023923e-01	1.437538e-06
CB	ELAVL1	exon_skip_168360	4.189939e-01	4.690028e-07
CB	CNOT4	exon_skip_168360	4.132622e-01	6.951553e-07
CB	MBNL1	exon_skip_168360	4.447745e-01	7.281005e-08
CB	MATR3	exon_skip_168360	4.549494e-01	3.342057e-08
CB	FUBP1	exon_skip_168360	4.010320e-01	1.571550e-06
CB	SRSF1	exon_skip_168360	5.103394e-01	2.993674e-10
CB	HNRNPH2	exon_skip_168360	4.452199e-01	7.040748e-08
CB	NUP42	exon_skip_102452	5.730533e-01	3.089745e-13
CB	SRSF9	exon_skip_102452	4.448315e-01	5.774140e-08
CB	NUP42	exon_skip_187961	6.412575e-01	2.510935e-19
CB	SRSF9	exon_skip_187961	4.821508e-01	2.121841e-10
DLPFC	RC3H1	exon_skip_175590	-4.137562e-01	1.242728e-12
DLPFC	G3BP2	exon_skip_175590	-4.834659e-01	2.791498e-17
FL	RBM3	exon_skip_110144	-6.284860e-01	1.632296e-20
FL	RBFOX2	exon_skip_294781	4.441789e-01	6.229721e-11
FL	MATR3	exon_skip_294781	4.184633e-01	9.406165e-10
FL	ILF2	exon_skip_294781	4.355714e-01	1.585426e-10
FL	HNRNPH2	exon_skip_294781	4.600201e-01	1.041196e-11
FL	SRSF2	exon_skip_158300	5.598797e-01	9.618808e-16
FL	RBFOX2	exon_skip_158300	5.337099e-01	3.377003e-14
FL	ELAVL4	exon_skip_158300	6.174889e-01	1.139445e-19
FL	SRSF11	exon_skip_158300	4.065424e-01	2.601870e-08
FL	MATR3	exon_skip_158300	6.178010e-01	1.079438e-19
FL	ILF2	exon_skip_158300	5.102607e-01	6.373497e-13
FL	RBM24	exon_skip_158300	5.370924e-01	2.168942e-14
FL	RALYL	exon_skip_158300	6.049758e-01	9.495407e-19
FL	HNRNPL	exon_skip_158300	5.055496e-01	1.119743e-12
FL	SRSF9	exon_skip_158300	5.023160e-01	1.640393e-12
FL	HNRNPH2	exon_skip_158300	4.829284e-01	1.491077e-11
FL	ESRP1	exon_skip_158300	5.450694e-01	7.484856e-15
FL	NOVA1	exon_skip_158300	4.053300e-01	2.887497e-08
FL	SRSF2	exon_skip_64653	4.828680e-01	5.827387e-13
FL	RBFOX2	exon_skip_64653	5.858510e-01	1.231484e-19
FL	ELAVL4	exon_skip_64653	6.684146e-01	5.391134e-27
FL	MATR3	exon_skip_64653	5.764482e-01	6.304479e-19
FL	ILF2	exon_skip_64653	5.561699e-01	1.795204e-17
FL	RBM24	exon_skip_64653	4.623521e-01	7.021803e-12
FL	PUM1	exon_skip_64653	4.003402e-01	5.100080e-09
FL	RALYL	exon_skip_64653	6.004351e-01	8.787622e-21
FL	HNRNPL	exon_skip_64653	4.528692e-01	2.100356e-11
FL	SRSF1	exon_skip_64653	4.068815e-01	2.706822e-09
FL	SRSF9	exon_skip_64653	4.595558e-01	9.734015e-12
FL	HNRNPH2	exon_skip_64653	5.238099e-01	2.399712e-15
FL	ESRP1	exon_skip_64653	4.179587e-01	8.970511e-10
FL	SRSF2	exon_skip_193616	4.534788e-01	2.203966e-11
FL	RBFOX2	exon_skip_193616	4.336482e-01	1.946453e-10
FL	ELAVL4	exon_skip_193616	4.425993e-01	7.409221e-11
FL	MATR3	exon_skip_193616	4.091646e-01	2.376132e-09
FL	ILF2	exon_skip_193616	4.392825e-01	1.063246e-10
FL	RALYL	exon_skip_193616	4.021433e-01	4.695663e-09
FL	ELAVL4	exon_skip_102452	6.305925e-01	6.678573e-21
FL	NUP42	exon_skip_102452	4.046374e-01	2.548300e-08
FL	SRSF9	exon_skip_102452	5.146951e-01	2.719342e-13
FL	HNRNPK	exon_skip_232091	5.893450e-01	6.622163e-20
FL	MBNL1	exon_skip_175590	-4.397291e-01	8.131365e-11
FL	ILF2	exon_skip_175590	-4.812691e-01	6.223706e-13
FL	G3BP2	exon_skip_175590	-6.382535e-01	3.676324e-24
FL	RBM24	exon_skip_175590	-4.456864e-01	4.206716e-11
FL	FUBP1	exon_skip_175590	-4.196937e-01	6.807152e-10
FL	SRSF9	exon_skip_175590	-4.009741e-01	4.385947e-09
HCC	RBM3	exon_skip_286749	-5.598002e-01	7.424351e-22
HCC	TRNAU1AP	exon_skip_102452	-4.342926e-01	9.378554e-14
HCC	SNRNP70	exon_skip_102452	-5.330692e-01	4.452642e-21
HCC	TRNAU1AP	exon_skip_187961	-4.939365e-01	5.163226e-18
HCC	SNRNP70	exon_skip_187961	-6.001604e-01	8.260404e-28
HCC	RBM6	exon_skip_232091	-6.953080e-01	1.293602e-40
HCC	CNOT4	exon_skip_232091	-5.052323e-01	4.994382e-19
HCC	TIA1	exon_skip_175590	5.731257e-01	5.655786e-25
HCC	TRNAU1AP	exon_skip_175590	4.653994e-01	6.427659e-16
HCC	G3BP2	exon_skip_167608	-4.774182e-01	2.368074e-15
IFG	ELAVL1	exon_skip_248175	4.194216e-01	3.293050e-02
IFG	ZNF638	exon_skip_248175	4.342472e-01	2.664854e-02
IFG	RBM3	exon_skip_248175	-5.321926e-01	5.133356e-03
IFG	TRA2A	exon_skip_248175	4.099321e-01	3.753822e-02
IFG	SRSF2	exon_skip_296442	5.357792e-01	3.298515e-03
IFG	MATR3	exon_skip_296442	4.662775e-01	1.238373e-02
IFG	ILF2	exon_skip_296442	5.877805e-01	1.005167e-03
IFG	ESRP2	exon_skip_296442	-4.733620e-01	1.095167e-02
IFG	SNRNP70	exon_skip_102452	-4.769327e-01	1.189141e-02
IFG	ELAVL4	exon_skip_187961	4.839772e-01	9.066548e-03
IFG	SNRNP70	exon_skip_187961	-4.938375e-01	7.567283e-03
IFG	TIA1	exon_skip_61154	-4.531799e-01	2.007192e-02
IFG	RBM6	exon_skip_232091	-5.426894e-01	2.847291e-03
IFG	ILF2	exon_skip_175590	-5.312132e-01	3.629145e-03
IFG	G3BP2	exon_skip_175590	-6.840468e-01	5.979586e-05
PCC	RBM3	exon_skip_110144	-6.132549e-01	1.346696e-20
PCC	RBFOX2	exon_skip_158300	6.552603e-01	2.783063e-26
PCC	ELAVL4	exon_skip_158300	5.429421e-01	5.838691e-17
PCC	SFPQ	exon_skip_158300	-4.036990e-01	2.337188e-09
PCC	SRSF11	exon_skip_158300	-4.165540e-01	6.345537e-10
PCC	PCBP4	exon_skip_158300	-4.700343e-01	1.491898e-12
PCC	PUM1	exon_skip_158300	4.440543e-01	3.220687e-11
PCC	RALYL	exon_skip_158300	4.426003e-01	3.796129e-11
PCC	ZC3H10	exon_skip_158300	-4.109999e-01	1.122163e-09
PCC	RBFOX2	exon_skip_64653	7.071588e-01	2.663720e-33
PCC	ELAVL4	exon_skip_64653	6.832409e-01	2.306393e-30
PCC	PCBP4	exon_skip_64653	-4.036698e-01	1.129485e-09
PCC	PUM1	exon_skip_64653	4.834993e-01	9.244575e-14
PCC	RALYL	exon_skip_64653	5.094414e-01	2.466396e-15
PCC	RBFOX2	exon_skip_296270	5.778243e-01	2.188194e-19
PCC	ELAVL4	exon_skip_296270	4.887965e-01	1.577858e-13
PCC	RALYL	exon_skip_296270	4.207961e-01	4.504579e-10
PCC	ELAVL4	exon_skip_102452	5.303101e-01	4.048777e-16
PCC	ELAVL4	exon_skip_187961	6.149476e-01	2.446612e-23
PCC	RBM6	exon_skip_232091	-5.098783e-01	3.141858e-15
PCC	G3BP2	exon_skip_175590	-6.705637e-01	2.899563e-28
PG	RBFOX2	exon_skip_294781	5.394392e-01	1.198953e-16
PG	MATR3	exon_skip_294781	4.529329e-01	1.304649e-11
PG	PCBP1	exon_skip_294781	4.151691e-01	8.067599e-10
PG	ILF2	exon_skip_294781	4.020793e-01	3.003797e-09
PG	PUM1	exon_skip_294781	4.617662e-01	4.610444e-12
PG	RALYL	exon_skip_294781	5.135166e-01	5.495929e-15
PG	HNRNPL	exon_skip_294781	4.124499e-01	1.065075e-09
PG	HNRNPH2	exon_skip_294781	4.085112e-01	1.585680e-09
PG	NOVA1	exon_skip_294781	4.059781e-01	2.042648e-09
PG	RBFOX2	exon_skip_64653	6.726503e-01	2.326384e-28
PG	ELAVL4	exon_skip_64653	6.502587e-01	5.053210e-26
PG	IGF2BP2	exon_skip_64653	-4.404373e-01	3.883290e-11
PG	MATR3	exon_skip_64653	4.246889e-01	2.203691e-10
PG	PCBP1	exon_skip_64653	5.666454e-01	8.300619e-19
PG	RBM24	exon_skip_64653	4.390738e-01	4.529164e-11
PG	PUM1	exon_skip_64653	4.789330e-01	3.758394e-13
PG	RALYL	exon_skip_64653	5.996118e-01	2.115560e-21
PG	HNRNPH2	exon_skip_64653	4.600285e-01	3.941127e-12
PG	RBFOX2	exon_skip_193616	4.448787e-01	3.282847e-11
PG	ELAVL4	exon_skip_193616	4.309606e-01	1.529259e-10
PG	HNRNPK	exon_skip_232091	6.118014e-01	3.956399e-22
PG	ILF2	exon_skip_175590	-4.586951e-01	3.223363e-12
PG	G3BP2	exon_skip_175590	-6.529613e-01	1.166282e-26
PG	RBM24	exon_skip_175590	-4.850133e-01	1.136047e-13
STG	SRSF11	exon_skip_168975	-4.082187e-01	1.880312e-04
STG	ZC3H10	exon_skip_168975	-4.349328e-01	6.189870e-05
STG	RBFOX2	exon_skip_294781	4.434448e-01	1.201435e-05
STG	MATR3	exon_skip_294781	4.663396e-01	3.612560e-06
STG	RALYL	exon_skip_294781	4.718683e-01	2.667159e-06
STG	HNRNPH2	exon_skip_294781	4.431542e-01	1.219227e-05
STG	SRSF9	exon_skip_63290	4.147401e-01	5.324484e-05
STG	ELAVL4	exon_skip_102452	5.174375e-01	3.251155e-06
STG	ELAVL4	exon_skip_65447	7.693773e-01	5.173782e-19
STG	NUP42	exon_skip_65447	5.578489e-01	9.221099e-09
STG	SRSF9	exon_skip_65447	5.854988e-01	1.089081e-09
STG	HNRNPK	exon_skip_232091	5.057409e-01	2.329134e-07
STG	MBNL1	exon_skip_175590	-4.837001e-01	1.037303e-06
STG	ILF2	exon_skip_175590	-5.186334e-01	1.184512e-07
STG	G3BP2	exon_skip_175590	-6.952668e-01	1.474535e-14
STG	RBM24	exon_skip_175590	-4.584770e-01	4.308207e-06
STG	FUBP1	exon_skip_175590	-4.350891e-01	1.463423e-05
STG	HNRNPCL1	exon_skip_175590	-4.307669e-01	1.816765e-05
STG	SRSF9	exon_skip_175590	-4.115355e-01	4.592373e-05
TC	RBM3	exon_skip_110144	-4.217458e-01	9.662778e-07
TC	RBFOX2	exon_skip_213257	-4.536375e-01	1.369055e-07
TC	ELAVL4	exon_skip_102452	8.669770e-01	3.497014e-44
TC	NUP42	exon_skip_102452	7.173002e-01	1.003637e-23
TC	SRSF9	exon_skip_102452	4.394060e-01	4.482197e-08
TC	ELAVL4	exon_skip_65447	8.793930e-01	1.580075e-50
TC	NUP42	exon_skip_65447	7.297016e-01	1.040237e-26
TC	SRSF9	exon_skip_65447	4.347163e-01	1.968080e-08
TC	ILF2	exon_skip_175590	-5.033794e-01	3.847909e-11
TC	G3BP2	exon_skip_175590	-6.877248e-01	1.289923e-22
TC	RBM24	exon_skip_175590	-7.096273e-01	1.408198e-24
TC	HNRNPD	exon_skip_175590	-5.579392e-01	8.182969e-14

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RelatedDrugs for NRCAM

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NRCAM

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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