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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NONO |
 Gene summary |
| Gene information | Gene symbol | NONO | Gene ID | 4841 |
| Gene name | non-POU domain containing octamer binding | |
| Synonyms | MRXS34|NMT55|NRB54|P54|P54NRB|PPP1R114 | |
| Cytomap | Xq13.1 | |
| Type of gene | protein-coding | |
| Description | non-POU domain-containing octamer-binding protein54 kDa nuclear RNA- and DNA-binding protein55 kDa nuclear proteinDNA-binding p52/p100 complex, 52 kDa subunitnon-POU domain-containing octamer (ATGCAAAT) binding proteinp54(nrb)protein phosphatase 1, | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NONO | GO:0002218 | activation of innate immune response | 28712728 |
| NONO | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 15790595 |
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Gene structures and expression levels for NONO |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147140
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000472185.1 | NONO-210:lncRNA:NONO | 1.476525e+02 | -1.182752e+00 | 7.809194e-09 | 2.440190e-07 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NONO |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_125339 | chrX | 71284397:71284453:71284984:71285097:71290629:71290791 | 71284984:71285097 |
| exon_skip_137917 | chrX | 71284402:71284453:71284984:71285097:71290629:71290791 | 71284984:71285097 |
| exon_skip_174502 | chrX | 71283694:71283721:71284397:71284453:71290629:71290791 | 71284397:71284453 |
| exon_skip_212806 | chrX | 71291869:71291972:71294398:71294528:71296565:71296660 | 71294398:71294528 |
| exon_skip_229294 | chrX | 71291917:71291972:71294398:71294528:71296565:71296660 | 71294398:71294528 |
| exon_skip_240893 | chrX | 71297377:71297461:71297836:71297938:71298469:71298508 | 71297836:71297938 |
| exon_skip_293092 | chrX | 71283615:71283721:71290629:71290791:71291779:71291972 | 71290629:71290791 |
| exon_skip_5936 | chrX | 71291917:71291972:71294227:71294528:71296565:71296660 | 71294227:71294528 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NONO |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373841 | 71290629 | 71290791 | 5CDS-5UTR |
| ENST00000276079 | 71284397 | 71284453 | 5UTR-5UTR |
| ENST00000373856 | 71284984 | 71285097 | 5UTR-5UTR |
| ENST00000276079 | 71294227 | 71294528 | Frame-shift |
| ENST00000373841 | 71294227 | 71294528 | Frame-shift |
| ENST00000373856 | 71294227 | 71294528 | Frame-shift |
| ENST00000276079 | 71297836 | 71297938 | Frame-shift |
| ENST00000373841 | 71297836 | 71297938 | Frame-shift |
| ENST00000373856 | 71297836 | 71297938 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276079 | 71284397 | 71284453 | 5UTR-5UTR |
| ENST00000373856 | 71284984 | 71285097 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276079 | 71284397 | 71284453 | 5UTR-5UTR |
| ENST00000373856 | 71284984 | 71285097 | 5UTR-5UTR |
| ENST00000276079 | 71294227 | 71294528 | Frame-shift |
| ENST00000373841 | 71294227 | 71294528 | Frame-shift |
| ENST00000373856 | 71294227 | 71294528 | Frame-shift |
| ENST00000276079 | 71297836 | 71297938 | Frame-shift |
| ENST00000373841 | 71297836 | 71297938 | Frame-shift |
| ENST00000373856 | 71297836 | 71297938 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NONO |
p-ENSG00000147140_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NONO |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NONO |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NONO |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NONO |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NONO |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SNRPA | exon_skip_174502 | -4.359581e-01 | 9.256960e-09 |
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RelatedDrugs for NONO |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NONO |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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