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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for NFIB |
Gene summary |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
NFIB | GO:0045893 | positive regulation of transcription, DNA-templated | 30388402 |
NFIB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9099724|19540848 |
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Gene structures and expression levels for NFIB |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000543693.5 | NFIB-210:protein_coding:NFIB | 4.408931e+02 | 1.048626e+00 | 1.507188e-04 | 7.787926e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NFIB |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_122403 | chr9 | 14088304:14088326:14120440:14120624:14125632:14125766 | 14120440:14120624 |
exon_skip_150039 | chr9 | 14087637:14088326:14093460:14093464:14102422:14102510 | 14093460:14093464 |
exon_skip_155038 | chr9 | 14112999:14113081:14116208:14116346:14120440:14120624 | 14116208:14116346 |
exon_skip_185283 | chr9 | 14088304:14088326:14102422:14102510:14112999:14113081 | 14102422:14102510 |
exon_skip_222630 | chr9 | 14088304:14088326:14093460:14093464:14102422:14102510 | 14093460:14093464 |
exon_skip_235921 | chr9 | 14088304:14088326:14102422:14102510:14120440:14120624 | 14102422:14102510 |
exon_skip_236436 | chr9 | 14088304:14088326:14112999:14113081:14116181:14116346 | 14112999:14113081 |
exon_skip_268078 | chr9 | 14146689:14146807:14150145:14150265:14155825:14155893 | 14150145:14150265 |
exon_skip_270040 | chr9 | 14088304:14088326:14112999:14113081:14116208:14116346 | 14112999:14113081 |
exon_skip_270417 | chr9 | 14102422:14102510:14112999:14113081:14116181:14116346 | 14112999:14113081 |
exon_skip_271074 | chr9 | 14155825:14155893:14179727:14179780:14306989:14307520 | 14179727:14179780 |
exon_skip_81554 | chr9 | 14112999:14113081:14116181:14116346:14120440:14120624 | 14116181:14116346 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NFIB |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000380959 | 14120440 | 14120624 | Frame-shift |
ENST00000380959 | 14179727 | 14179780 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000380959 | 14150145 | 14150265 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NFIB |
p-ENSG00000147862_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000380959 | 8215 | 420 | 14179727 | 14179780 | 1037 | 1089 | 187 | 205 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O00712 | 187 | 205 | 1 | 252 | Alternative sequence | ID=VSP_054713;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
O00712 | 187 | 205 | 187 | 188 | Alternative sequence | ID=VSP_003545;Note=In isoform 3. QD->AR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9099724;Dbxref=PMID:9099724 |
O00712 | 187 | 205 | 189 | 420 | Alternative sequence | ID=VSP_003546;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9099724;Dbxref=PMID:9099724 |
O00712 | 187 | 205 | 1 | 420 | Chain | ID=PRO_0000100195;Note=Nuclear factor 1 B-type |
O00712 | 187 | 205 | 1 | 195 | DNA binding | Note=CTF/NF-I;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00436 |
O00712 | 187 | 205 | 198 | 198 | Sequence conflict | Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NFIB |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NFIB |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NFIB |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NFIB |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NFIB |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TIA1 | exon_skip_235921 | 4.948581e-01 | 1.625134e-10 |
IFG | BOLL | exon_skip_235921 | -4.667378e-01 | 1.411707e-02 |
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RelatedDrugs for NFIB |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFIB |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |