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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for NDUFA10 |
Gene summary |
Gene information | Gene symbol | NDUFA10 | Gene ID | 4705 |
Gene name | NADH:ubiquinone oxidoreductase subunit A10 | |
Synonyms | CI-42KD|CI-42k|MC1DN22 | |
Cytomap | 2q37.3 | |
Type of gene | protein-coding | |
Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNADH-ubiquinone oxidoreductase 42 kDa subunitcomplex I 42kDa subunit | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 26125932(Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NDUFA10 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000476216.5 | NDUFA10-211:retained_intron:NDUFA10 | 6.612612e+02 | -8.131425e-01 | 5.890612e-10 | 2.824349e-08 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NDUFA10 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_112841 | chr2 | 239960739:239961186:239982115:239982219:239990074:239990175 | 239982115:239982219 |
exon_skip_127298 | chr2 | 240021197:240021412:240022172:240022340:240025227:240025243 | 240022172:240022340 |
exon_skip_151036 | chr2 | 240007316:240007370:240011617:240014860:240018553:240018639 | 240011617:240014860 |
exon_skip_179969 | chr2 | 239990074:239990182:240005210:240005295:240007316:240007370 | 240005210:240005295 |
exon_skip_244903 | chr2 | 240021401:240021412:240022172:240022341:240025227:240025243 | 240022172:240022341 |
exon_skip_252196 | chr2 | 240014799:240014860:240018553:240018639:240021197:240021412 | 240018553:240018639 |
exon_skip_255743 | chr2 | 240007316:240007370:240011617:240014860:240018553:240018564 | 240011617:240014860 |
exon_skip_259213 | chr2 | 239961164:239961186:239990074:239990182:240005210:240005237 | 239990074:239990182 |
exon_skip_50885 | chr2 | 240014841:240014860:240018553:240018639:240021197:240021412 | 240018553:240018639 |
exon_skip_51865 | chr2 | 239961164:239961186:239990074:239990182:240005210:240005295 | 239990074:239990182 |
exon_skip_66550 | chr2 | 240021197:240021412:240022172:240022341:240025227:240025243 | 240022172:240022341 |
exon_skip_68033 | chr2 | 239990076:239990182:240005210:240005295:240007316:240007370 | 240005210:240005295 |
exon_skip_941 | chr2 | 240021401:240021412:240022172:240022340:240025227:240025243 | 240022172:240022340 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NDUFA10 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for NDUFA10 |
p-ENSG00000130414_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NDUFA10 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NDUFA10 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NDUFA10 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
ADstage | MSBB | IFG | exon_skip_127298 | -4.153955e-01 | 2.792984e-02 | chr2 | - | 240021197 | 240021412 | 240022172 | 240022340 | 240025227 | 240025243 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NDUFA10 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NDUFA10 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NDUFA10 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFA10 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |