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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HNRNPM |
 Gene summary |
| Gene information | Gene symbol | HNRNPM | Gene ID | 4670 |
| Gene name | heterogeneous nuclear ribonucleoprotein M | |
| Synonyms | CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M | |
| Cytomap | 19p13.2 | |
| Type of gene | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4 | |
| Modification date | 20200322 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for HNRNPM |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000099783
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000594907.5 | HNRNPM-204:protein_coding:HNRNPM | 7.392887e+00 | 5.626865e+00 | 1.603601e-05 | 7.144570e-04 |
| PG | UP | ENST00000597081.1 | HNRNPM-207:lncRNA:HNRNPM | 1.205731e+01 | 2.490079e+00 | 7.975336e-04 | 1.238599e-02 |
| CB | UP | ENST00000597270.1 | HNRNPM-208:protein_coding:HNRNPM | 1.002810e+02 | 8.884044e-01 | 3.978709e-11 | 2.946693e-09 |
| CB | DOWN | ENST00000348943.7 | HNRNPM-202:protein_coding:HNRNPM | 8.591008e+02 | -9.876701e-01 | 6.310305e-08 | 1.436832e-06 |
| CB | DOWN | ENST00000596295.1 | HNRNPM-205:protein_coding:HNRNPM | 4.891340e+00 | -8.384592e-01 | 1.530939e-02 | 4.903280e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HNRNPM |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112598 | chr19 | 8444994:8445111:8455405:8455574:8462529:8462581 | 8455405:8455574 |
| exon_skip_15382 | chr19 | 8455410:8455574:8462529:8462581:8463497:8463500 | 8462529:8462581 |
| exon_skip_193260 | chr19 | 8455542:8455574:8462529:8462581:8463497:8463504 | 8462529:8462581 |
| exon_skip_225865 | chr19 | 8471326:8471427:8473664:8473708:8474167:8474244 | 8473664:8473708 |
| exon_skip_229910 | chr19 | 8465324:8465362:8465480:8465515:8466235:8466388 | 8465480:8465515 |
| exon_skip_23405 | chr19 | 8455542:8455574:8462529:8462581:8463497:8463500 | 8462529:8462581 |
| exon_skip_25578 | chr19 | 8474167:8474244:8483158:8483211:8485603:8485648 | 8483158:8483211 |
| exon_skip_265625 | chr19 | 8471326:8471427:8474167:8474244:8483158:8483211 | 8474167:8474244 |
| exon_skip_272893 | chr19 | 8455405:8455574:8462529:8462581:8463497:8463500 | 8462529:8462581 |
| exon_skip_276569 | chr19 | 8463593:8463686:8465324:8465362:8465480:8465515 | 8465324:8465362 |
| exon_skip_293970 | chr19 | 8487024:8487075:8488009:8488066:8488691:8488946 | 8488009:8488066 |
| exon_skip_62243 | chr19 | 8465324:8465362:8465480:8465515:8466235:8466343 | 8465480:8465515 |
| exon_skip_65893 | chr19 | 8445082:8445111:8455405:8455574:8462529:8462581 | 8455405:8455574 |
| exon_skip_6609 | chr19 | 8455405:8455574:8462529:8462581:8463497:8463504 | 8462529:8462581 |
| exon_skip_90714 | chr19 | 8468816:8468834:8471326:8471427:8473664:8473708 | 8471326:8471427 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HNRNPM |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325495 | 8455405 | 8455574 | Frame-shift |
| ENST00000325495 | 8462529 | 8462581 | Frame-shift |
| ENST00000325495 | 8473664 | 8473708 | In-frame |
| ENST00000325495 | 8483158 | 8483211 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325495 | 8462529 | 8462581 | Frame-shift |
| ENST00000325495 | 8473664 | 8473708 | In-frame |
| ENST00000325495 | 8483158 | 8483211 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325495 | 8455405 | 8455574 | Frame-shift |
| ENST00000325495 | 8462529 | 8462581 | Frame-shift |
| ENST00000325495 | 8471326 | 8471427 | In-frame |
| ENST00000325495 | 8473664 | 8473708 | In-frame |
| ENST00000325495 | 8483158 | 8483211 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HNRNPM |
p-ENSG00000099783_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325495 | 2511 | 730 | 8473664 | 8473708 | 1040 | 1083 | 333 | 347 |
| ENST00000325495 | 2511 | 730 | 8483158 | 8483211 | 1163 | 1215 | 374 | 391 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325495 | 2511 | 730 | 8473664 | 8473708 | 1040 | 1083 | 333 | 347 |
| ENST00000325495 | 2511 | 730 | 8483158 | 8483211 | 1163 | 1215 | 374 | 391 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325495 | 2511 | 730 | 8471326 | 8471427 | 938 | 1038 | 299 | 332 |
| ENST00000325495 | 2511 | 730 | 8473664 | 8473708 | 1040 | 1083 | 333 | 347 |
| ENST00000325495 | 2511 | 730 | 8483158 | 8483211 | 1163 | 1215 | 374 | 391 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P52272 | 333 | 347 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 333 | 347 | 345 | 345 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 374 | 391 | 390 | 396 | Compositional bias | Note=Poly-Gly |
| P52272 | 374 | 391 | 381 | 381 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 388 | 388 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 |
| P52272 | 374 | 391 | 377 | 377 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P52272 | 333 | 347 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 333 | 347 | 345 | 345 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 374 | 391 | 390 | 396 | Compositional bias | Note=Poly-Gly |
| P52272 | 374 | 391 | 381 | 381 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 388 | 388 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 |
| P52272 | 374 | 391 | 377 | 377 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P52272 | 299 | 332 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 333 | 347 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 333 | 347 | 345 | 345 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 374 | 391 | 390 | 396 | Compositional bias | Note=Poly-Gly |
| P52272 | 374 | 391 | 381 | 381 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 374 | 391 | 388 | 388 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 |
| P52272 | 374 | 391 | 377 | 377 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
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3'-UTR located exon skipping events that lost miRNA binding sites in HNRNPM |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for HNRNPM |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HNRNPM |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_225865 | 3.762934e-01 | 4.842744e-02 | chr19 | + | 8471326 | 8471427 | 8473664 | 8473708 | 8474167 | 8474244 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HNRNPM |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_23405 | rs2967605 | chr19:8404854 | 3.214771e-04 | 4.276017e-02 |
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Correlation with RNA binding proteins (RBPs) for HNRNPM |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_225865 | -4.474801e-01 | 3.346752e-09 |
| CB | HNRNPA2B1 | exon_skip_225865 | -5.620863e-01 | 1.266514e-14 |
| CB | SRSF1 | exon_skip_225865 | -4.493328e-01 | 2.831565e-09 |
| CB | HNRNPF | exon_skip_225865 | -4.343447e-01 | 1.064231e-08 |
| CB | DAZAP1 | exon_skip_25578 | -4.535532e-01 | 1.927652e-09 |
| CB | PCBP4 | exon_skip_25578 | 6.248851e-01 | 1.332947e-18 |
| CB | HNRNPA2B1 | exon_skip_25578 | -4.330546e-01 | 1.189160e-08 |
| CB | NUP42 | exon_skip_25578 | 4.695130e-01 | 4.290950e-10 |
| DLPFC | KHDRBS2 | exon_skip_225865 | -5.876617e-01 | 3.857981e-33 |
| HCC | KHDRBS2 | exon_skip_225865 | -4.085192e-01 | 2.096734e-12 |
| HCC | MSI1 | exon_skip_25578 | -4.424831e-01 | 1.622997e-14 |
| HCC | HNRNPF | exon_skip_25578 | -4.626282e-01 | 6.951122e-16 |
| IFG | ILF2 | exon_skip_225865 | -5.804687e-01 | 1.202261e-03 |
| IFG | KHDRBS2 | exon_skip_225865 | -4.777430e-01 | 1.013741e-02 |
| IFG | KHDRBS3 | exon_skip_225865 | -6.316946e-01 | 3.117475e-04 |
| IFG | NUP42 | exon_skip_225865 | -5.306125e-01 | 3.674683e-03 |
| IFG | SRSF9 | exon_skip_225865 | -4.504728e-01 | 1.614659e-02 |
| IFG | HNRNPH2 | exon_skip_225865 | -6.103276e-01 | 5.629729e-04 |
| IFG | EIF4B | exon_skip_225865 | -4.539106e-01 | 1.525657e-02 |
| PCC | HNRNPF | exon_skip_225865 | 4.840805e-01 | 4.967660e-14 |
| TC | SRSF1 | exon_skip_15382 | 4.163847e-01 | 4.341579e-08 |
| TC | KHDRBS2 | exon_skip_225865 | -4.834943e-01 | 9.409454e-11 |
| TC | KHDRBS3 | exon_skip_225865 | -4.723917e-01 | 2.851656e-10 |
| TC | NUP42 | exon_skip_225865 | -4.301096e-01 | 1.376568e-08 |
| TC | HNRNPH2 | exon_skip_225865 | -4.328999e-01 | 1.083016e-08 |
| TC | ESRP1 | exon_skip_225865 | -4.615648e-01 | 8.097481e-10 |
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RelatedDrugs for HNRNPM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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