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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZFHX3 |
 Gene summary |
| Gene information | Gene symbol | ZFHX3 | Gene ID | 463 |
| Gene name | zinc finger homeobox 3 | |
| Synonyms | ATBF1|ATBT|C16orf47|ZFH-3|ZNF927 | |
| Cytomap | 16q22.2-q22.3 | |
| Type of gene | protein-coding | |
| Description | zinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3 | |
| Modification date | 20200313 | |
| UniProtAcc | Q15911, Q8N2Y6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ZFHX3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11314020 |
| ZFHX3 | GO:0045893 | positive regulation of transcription, DNA-templated | 20599712 |
| ZFHX3 | GO:0071559 | response to transforming growth factor beta | 20599712 |
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Gene structures and expression levels for ZFHX3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000140836
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZFHX3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102602 | chr16 | 72950469:72950965:72957427:72960194:73058530:73058708 | 72957427:72960194 |
| exon_skip_187491 | chr16 | 72950469:72950965:72957427:72960194:73058530:73058543 | 72957427:72960194 |
| exon_skip_33175 | chr16 | 73093235:73093598:73130968:73131094:73143752:73143831 | 73130968:73131094 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZFHX3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000641206 | 72957427 | 72960194 | 3UTR-3CDS |
| ENST00000641206 | 73130968 | 73131094 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000641206 | 73130968 | 73131094 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZFHX3 |
p-ENSG00000140836_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZFHX3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000641206 | 73130968 | 73131094 | hsa-miR-6715b-5p | chr16:73130988-73130995 | 8mer-1a | chr16:73130978-73130998 | 157.00 | -21.95 |
| Mayo | ENST00000641206 | 73130968 | 73131094 | hsa-miR-4269 | chr16:73130988-73130995 | 8mer-1a | chr16:73130978-73130998 | 157.00 | -21.95 |
| ROSMAP | ENST00000641206 | 73130968 | 73131094 | hsa-miR-6715b-5p | chr16:73130988-73130995 | 8mer-1a | chr16:73130978-73130998 | 157.00 | -21.95 |
| ROSMAP | ENST00000641206 | 73130968 | 73131094 | hsa-miR-4269 | chr16:73130988-73130995 | 8mer-1a | chr16:73130978-73130998 | 157.00 | -21.95 |
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SNVs in the skipped exons for ZFHX3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZFHX3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFHX3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZFHX3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZFHX3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFHX3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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