Gene summary |
Gene information | Gene symbol | MYH11 |
Gene ID | 4629 | Gene name | myosin heavy chain 11 |
Synonyms | AAT4|FAA4|SMHC|SMMHC |
Cytomap | 16p13.11 |
Type of gene | protein-coding |
Description | myosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle |
Modification date | 20200322 |
UniProtAcc | A0A024QZJ4, A0A024QZJ6, A0A494C024, B1PS43, P35749, Q4G140, Q66K75, |
Context | |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000133392
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
STG | UP | 4.251830e+02 | 1.337643e+00 | 8.413056e-05 | 5.313050e-03 |
PG | UP | 3.195799e+02 | 8.032374e-01 | 1.398704e-04 | 1.197694e-03 |
TC | UP | 3.861616e+02 | 1.076667e+00 | 5.007845e-12 | 6.470318e-10 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000300036.6 | MYH11-201:protein_coding:MYH11 | 3.357137e+02 | 1.467468e+00 | 6.606581e-04 | 3.116459e-02 |
PG | UP | ENST00000573908.1 | MYH11-208:lncRNA:MYH11 | 6.130908e+00 | 1.572554e+00 | 2.726190e-05 | 1.052726e-03 |
CB | UP | ENST00000300036.6 | MYH11-201:protein_coding:MYH11 | 1.184977e+02 | 9.708429e-01 | 5.237755e-05 | 4.277582e-04 |
TC | UP | ENST00000300036.6 | MYH11-201:protein_coding:MYH11 | 2.911667e+02 | 1.417216e+00 | 7.631242e-13 | 2.932187e-10 |
TC | UP | ENST00000452625.7 | MYH11-203:protein_coding:MYH11 | 9.644412e+01 | 1.360650e+00 | 2.392735e-06 | 8.207856e-05 |
TC | UP | ENST00000652121.1 | MYH11-213:nonsense_mediated_decay:MYH11 | 1.468193e+00 | 3.431047e+00 | 1.511733e-03 | 1.353241e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_123720 | chr16 | 15782385:15782477:15784698:15784718:15786630:15786732 | 15784698:15784718 |
exon_skip_252105 | chr16 | 15704113:15704123:15708803:15708841:15714909:15715081 | 15708803:15708841 |
exon_skip_279465 | chr16 | 15760540:15760658:15763796:15763891:15771569:15771712 | 15763796:15763891 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000300036 | 15763796 | 15763891 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
p-ENSG00000133392_img4.png
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Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000300036 | 6046 | 1972 | 15763796 | 15763891 | 1144 | 1238 | 344 | 376 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P35749 | 344 | 376 | 1 | 1972 | Chain | ID=PRO_0000123424;Note=Myosin-11 |
P35749 | 344 | 376 | 85 | 783 | Domain | Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |