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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MYH10 |
 Gene summary |
| Gene information | Gene symbol | MYH10 | Gene ID | 4628 |
| Gene name | myosin heavy chain 10 | |
| Synonyms | NMMHC-IIB|NMMHCB | |
| Cytomap | 17p13.1 | |
| Type of gene | protein-coding | |
| Description | myosin-10cellular myosin heavy chain, type Bmyosin heavy chain, nonmuscle type Bmyosin, heavy chain 10, non-musclemyosin, heavy polypeptide 10, non-musclenonmuscle myosin II heavy chain-Bnonmuscle myosin heavy chain IIB | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MYH10 | GO:0000281 | mitotic cytokinesis | 15774463 |
| MYH10 | GO:0030048 | actin filament-based movement | 15845534 |
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Gene structures and expression levels for MYH10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000133026
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | DOWN | ENST00000476737.1 | MYH10-209:retained_intron:MYH10 | 3.480019e+00 | -1.441020e+00 | 1.595799e-05 | 1.987724e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MYH10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_130930 | chr17 | 8521092:8521285:8530623:8530685:8535387:8535501 | 8530623:8530685 |
| exon_skip_156140 | chr17 | 8622902:8623277:8623424:8623497:8630654:8630717 | 8623424:8623497 |
| exon_skip_166433 | chr17 | 8569720:8569812:8576643:8576672:8577236:8577338 | 8576643:8576672 |
| exon_skip_282392 | chr17 | 8535387:8535501:8535758:8535931:8542107:8542280 | 8535758:8535931 |
| exon_skip_287981 | chr17 | 8577306:8577338:8589081:8589108:8604826:8604893 | 8589081:8589108 |
| exon_skip_40531 | chr17 | 8508554:8508677:8509812:8509949:8512451:8512657 | 8509812:8509949 |
| exon_skip_58188 | chr17 | 8569720:8569812:8576643:8576672:8577236:8577250 | 8576643:8576672 |
| exon_skip_61793 | chr17 | 8569720:8569812:8576643:8576669:8577236:8577250 | 8576643:8576669 |
| exon_skip_82295 | chr17 | 8569720:8569812:8576643:8576669:8577236:8577338 | 8576643:8576669 |
| exon_skip_8838 | chr17 | 8493733:8493885:8495137:8495241:8499270:8499476 | 8495137:8495241 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_166433 | MSBB_PG | 7.297015e-01 | 8.522642e-01 | -1.225627e-01 | 7.708675e-04 |
| exon_skip_166433 | Mayo_TC | 4.592500e-01 | 6.005263e-01 | -1.412763e-01 | 2.687869e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for MYH10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000269243 | 8589081 | 8589108 | Frame-shift |
| ENST00000269243 | 8509812 | 8509949 | In-frame |
| ENST00000269243 | 8535758 | 8535931 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000269243 | 8589081 | 8589108 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000269243 | 8589081 | 8589108 | Frame-shift |
| ENST00000269243 | 8495137 | 8495241 | In-frame |
| ENST00000269243 | 8535758 | 8535931 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MYH10 |
p-ENSG00000133026_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000269243 | 7679 | 1976 | 8535758 | 8535931 | 1715 | 1887 | 525 | 582 |
| ENST00000269243 | 7679 | 1976 | 8509812 | 8509949 | 2999 | 3135 | 953 | 998 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000269243 | 7679 | 1976 | 8535758 | 8535931 | 1715 | 1887 | 525 | 582 |
| ENST00000269243 | 7679 | 1976 | 8495137 | 8495241 | 3998 | 4101 | 1286 | 1320 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35580 | 525 | 582 | 567 | 569 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 572 | 578 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 1 | 1976 | Chain | ID=PRO_0000123421;Note=Myosin-10 |
| P35580 | 525 | 582 | 85 | 783 | Domain | Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782 |
| P35580 | 525 | 582 | 531 | 538 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 546 | 556 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 953 | 998 | 1 | 1976 | Chain | ID=PRO_0000123421;Note=Myosin-10 |
| P35580 | 953 | 998 | 845 | 1976 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35580 | 953 | 998 | 908 | 1976 | Natural variant | ID=VAR_078650;Note=Probable disease-associated mutation found in a patient with intrauterine growth restriction%2C microcephaly%2C developmental delay%2C failure to thrive%2C congenital bilateral hip dysplasia%2C cerebral and cerebellar atrophy%2C hydroce |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35580 | 525 | 582 | 567 | 569 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 572 | 578 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 1 | 1976 | Chain | ID=PRO_0000123421;Note=Myosin-10 |
| P35580 | 525 | 582 | 85 | 783 | Domain | Note=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782 |
| P35580 | 525 | 582 | 531 | 538 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 525 | 582 | 546 | 556 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PD3 |
| P35580 | 1286 | 1320 | 1 | 1976 | Chain | ID=PRO_0000123421;Note=Myosin-10 |
| P35580 | 1286 | 1320 | 845 | 1976 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35580 | 1286 | 1320 | 1301 | 1301 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61879 |
| P35580 | 1286 | 1320 | 908 | 1976 | Natural variant | ID=VAR_078650;Note=Probable disease-associated mutation found in a patient with intrauterine growth restriction%2C microcephaly%2C developmental delay%2C failure to thrive%2C congenital bilateral hip dysplasia%2C cerebral and cerebellar atrophy%2C hydroce |
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3'-UTR located exon skipping events that lost miRNA binding sites in MYH10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MYH10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MYH10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYH10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| TC | exon_skip_156140 | rs8079726 | chr17:8531887 | 8.709034e-05 | 1.461436e-02 |
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Correlation with RNA binding proteins (RBPs) for MYH10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPDL | exon_skip_130930 | 4.344660e-01 | 2.776358e-08 |
| CB | PUF60 | exon_skip_130930 | 4.507369e-01 | 7.124628e-09 |
| CB | HNRNPK | exon_skip_82295 | 4.337511e-01 | 7.460946e-07 |
| FL | RALYL | exon_skip_130930 | 5.855153e-01 | 4.674298e-19 |
| FL | NOVA1 | exon_skip_130930 | 5.121972e-01 | 3.107531e-14 |
| HCC | TRNAU1AP | exon_skip_130930 | -4.627919e-01 | 1.247924e-15 |
| HCC | PTBP1 | exon_skip_130930 | -6.097612e-01 | 1.115484e-28 |
| HCC | SRSF5 | exon_skip_130930 | -4.012792e-01 | 8.633640e-12 |
| HCC | HNRNPF | exon_skip_82295 | -5.546407e-01 | 2.248786e-22 |
| HCC | HNRNPA2B1 | exon_skip_166433 | -4.551577e-01 | 7.448036e-15 |
| HCC | SRSF1 | exon_skip_166433 | -4.003837e-01 | 1.514234e-11 |
| HCC | HNRNPF | exon_skip_166433 | -6.217355e-01 | 1.591230e-29 |
| IFG | NOVA1 | exon_skip_130930 | 4.358731e-01 | 2.041792e-02 |
| IFG | ILF2 | exon_skip_82295 | 4.576838e-01 | 3.695589e-02 |
| IFG | HNRNPH2 | exon_skip_82295 | 4.895850e-01 | 2.427901e-02 |
| IFG | ESRP1 | exon_skip_82295 | 4.813730e-01 | 2.714943e-02 |
| IFG | RBM25 | exon_skip_166433 | -4.130861e-01 | 2.890185e-02 |
| IFG | TRA2A | exon_skip_166433 | -4.317753e-01 | 2.177065e-02 |
| PCC | RALYL | exon_skip_130930 | 4.845299e-01 | 4.728434e-13 |
| PCC | PTBP1 | exon_skip_130930 | -5.626330e-01 | 6.328639e-18 |
| PCC | HNRNPF | exon_skip_82295 | -4.791695e-01 | 1.572520e-12 |
| PCC | HNRNPF | exon_skip_166433 | -5.578826e-01 | 2.405685e-17 |
| PG | HNRNPDL | exon_skip_130930 | 4.100310e-01 | 1.062378e-07 |
| PG | RALYL | exon_skip_130930 | 7.164666e-01 | 7.364269e-26 |
| PG | PTBP1 | exon_skip_130930 | -5.774906e-01 | 2.974237e-15 |
| PG | NOVA1 | exon_skip_130930 | 5.556974e-01 | 5.082994e-14 |
| PG | ILF2 | exon_skip_166433 | 5.090153e-01 | 1.017598e-13 |
| PG | HNRNPK | exon_skip_166433 | 4.913903e-01 | 9.270425e-13 |
| PG | HNRNPL | exon_skip_166433 | 4.820877e-01 | 2.830195e-12 |
| PG | HNRNPH2 | exon_skip_166433 | 5.894557e-01 | 6.987742e-19 |
| STG | RALYL | exon_skip_130930 | 5.884115e-01 | 6.122263e-09 |
| STG | NOVA1 | exon_skip_130930 | 4.140061e-01 | 1.104404e-04 |
| STG | ILF2 | exon_skip_166433 | 5.107032e-01 | 5.065141e-07 |
| STG | HNRNPK | exon_skip_166433 | 4.789781e-01 | 3.082825e-06 |
| STG | HNRNPL | exon_skip_166433 | 5.362510e-01 | 1.029682e-07 |
| STG | HNRNPH2 | exon_skip_166433 | 5.741034e-01 | 7.515388e-09 |
| TC | HNRNPDL | exon_skip_130930 | 5.295508e-01 | 8.833632e-12 |
| TC | RALYL | exon_skip_130930 | 8.227718e-01 | 1.164502e-36 |
| TC | PTBP1 | exon_skip_130930 | -4.036212e-01 | 5.266843e-07 |
| TC | PTBP3 | exon_skip_130930 | 4.786102e-01 | 1.298902e-09 |
| TC | SRSF5 | exon_skip_130930 | 4.863652e-01 | 6.400284e-10 |
| TC | NOVA1 | exon_skip_130930 | 7.351897e-01 | 9.508566e-26 |
| TC | ILF2 | exon_skip_82295 | 5.155435e-01 | 4.367523e-09 |
| TC | HNRNPK | exon_skip_82295 | 4.172643e-01 | 3.864480e-06 |
| TC | HNRNPL | exon_skip_82295 | 4.013737e-01 | 9.606548e-06 |
| TC | SRSF1 | exon_skip_82295 | 4.128182e-01 | 5.009378e-06 |
| TC | HNRNPH2 | exon_skip_82295 | 6.926277e-01 | 1.381945e-17 |
| TC | ESRP1 | exon_skip_82295 | 6.051060e-01 | 9.983549e-13 |
| TC | RBM25 | exon_skip_166433 | 4.363404e-01 | 9.819272e-08 |
| TC | ILF2 | exon_skip_166433 | 5.445422e-01 | 6.052693e-12 |
| TC | HNRNPK | exon_skip_166433 | 4.156649e-01 | 4.392260e-07 |
| TC | HNRNPL | exon_skip_166433 | 4.619552e-01 | 1.329435e-08 |
| TC | HNRNPH2 | exon_skip_166433 | 7.351974e-01 | 1.479826e-24 |
| TC | ESRP1 | exon_skip_166433 | 5.969476e-01 | 1.375628e-14 |
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RelatedDrugs for MYH10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYH10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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