|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for MYB |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MYB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10233885|20484083 |
Top |
Gene structures and expression levels for MYB |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000118513
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| TC | DOWN | 1.346734e+01 | -8.240825e-01 | 1.117819e-05 | 1.460192e-04 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MYB |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_120354 | chr6 | 135194356:135194460:135194960:135195081:135195748:135195917 | 135194960:135195081 |
| exon_skip_152924 | chr6 | 135193838:135193918:135194356:135194451:135195748:135195917 | 135194356:135194451 |
| exon_skip_260022 | chr6 | 135193838:135193918:135194356:135194460:135195748:135195917 | 135194356:135194460 |
| exon_skip_272021 | chr6 | 135189791:135189883:135190127:135190347:135192324:135192558 | 135190127:135190347 |
| exon_skip_287429 | chr6 | 135195748:135196002:135196961:135197323:135198908:135199050 | 135196961:135197323 |
| exon_skip_83330 | chr6 | 135186018:135186020:135187834:135187905:135189791:135189883 | 135187834:135187905 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MYB |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367814 | 135190127 | 135190347 | Frame-shift |
| ENST00000367814 | 135187834 | 135187905 | In-frame |
| ENST00000367814 | 135194356 | 135194460 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367814 | 135187834 | 135187905 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for MYB |
p-ENSG00000118513_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367814 | 3319 | 640 | 135187834 | 135187905 | 329 | 399 | 47 | 71 |
| ENST00000367814 | 3319 | 640 | 135194356 | 135194460 | 1031 | 1134 | 281 | 316 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367814 | 3319 | 640 | 135187834 | 135187905 | 329 | 399 | 47 | 71 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P10242 | 47 | 71 | 1 | 640 | Chain | ID=PRO_0000197048;Note=Transcriptional activator Myb |
| P10242 | 47 | 71 | 63 | 86 | DNA binding | Note=H-T-H motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625 |
| P10242 | 47 | 71 | 35 | 86 | Domain | Note=HTH myb-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625 |
| P10242 | 281 | 316 | 282 | 316 | Alternative sequence | ID=VSP_046658;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 |
| P10242 | 281 | 316 | 314 | 316 | Alternative sequence | ID=VSP_003293;Note=In isoform 2 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15169551,ECO:0000303|PubMed:2202948,ECO:0000303|Ref.6;Dbxref=PMID:15169551,PMID:2202948 |
| P10242 | 281 | 316 | 1 | 640 | Chain | ID=PRO_0000197048;Note=Transcriptional activator Myb |
| P10242 | 281 | 316 | 275 | 327 | Region | Note=Transcription activation domain (PubMed:2189102);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2189102;Dbxref=PMID:2189102 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P10242 | 47 | 71 | 1 | 640 | Chain | ID=PRO_0000197048;Note=Transcriptional activator Myb |
| P10242 | 47 | 71 | 63 | 86 | DNA binding | Note=H-T-H motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625 |
| P10242 | 47 | 71 | 35 | 86 | Domain | Note=HTH myb-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00625 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in MYB |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for MYB |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for MYB |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYB |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for MYB |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for MYB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MYB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|