|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for MSN |
 Gene summary |
| Gene information | Gene symbol | MSN | Gene ID | 4478 |
| Gene name | moesin | |
| Synonyms | HEL70|IMD50 | |
| Cytomap | Xq12 | |
| Type of gene | protein-coding | |
| Description | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MSN | GO:0001771 | immunological synapse formation | 27405666 |
| MSN | GO:0042098 | T cell proliferation | 27405666 |
| MSN | GO:0070489 | T cell aggregation | 27405666 |
| MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
| MSN | GO:0072678 | T cell migration | 27405666 |
Top |
Gene structures and expression levels for MSN |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000147065
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MSN |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112343 | chrX | 65716823:65716901:65727814:65727909:65729438:65729589 | 65727814:65727909 |
| exon_skip_2441 | chrX | 65716818:65716901:65727814:65727909:65729438:65729589 | 65727814:65727909 |
| exon_skip_80369 | chrX | 65731838:65731984:65733184:65733280:65735267:65735430 | 65733184:65733280 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MSN |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360270 | 65733184 | 65733280 | Frame-shift |
| ENST00000360270 | 65727814 | 65727909 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360270 | 65733184 | 65733280 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360270 | 65733184 | 65733280 | Frame-shift |
| ENST00000360270 | 65727814 | 65727909 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for MSN |
p-ENSG00000147065_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360270 | 3961 | 577 | 65727814 | 65727909 | 270 | 364 | 32 | 64 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360270 | 3961 | 577 | 65727814 | 65727909 | 270 | 364 | 32 | 64 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P26038 | 32 | 64 | 45 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 56 | 58 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 61 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 2 | 577 | Chain | ID=PRO_0000219416;Note=Moesin |
| P26038 | 32 | 64 | 2 | 295 | Domain | Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084 |
| P26038 | 32 | 64 | 26 | 37 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 42 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P26038 | 32 | 64 | 45 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 56 | 58 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 61 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 2 | 577 | Chain | ID=PRO_0000219416;Note=Moesin |
| P26038 | 32 | 64 | 2 | 295 | Domain | Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084 |
| P26038 | 32 | 64 | 26 | 37 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
| P26038 | 32 | 64 | 42 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EF1 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in MSN |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for MSN |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for MSN |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MSN |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for MSN |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for MSN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MSN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|