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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TMEM198B |
 Gene summary |
| Gene information | Gene symbol | TMEM198B | Gene ID | 440104 |
| Gene name | transmembrane protein 198B (pseudogene) | |
| Synonyms | - | |
| Cytomap | 12q13.2 | |
| Type of gene | pseudo | |
| Description | 1110012D08Rik pseudogenetransmembrane protein 198, pseudogene | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TMEM198B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000182796
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000637951.1 | TMEM198B-215:lncRNA:TMEM198B | 2.043288e+00 | 1.171633e+00 | 1.281468e-03 | 1.742173e-02 |
| CB | DOWN | ENST00000471276.5 | TMEM198B-201:lncRNA:TMEM198B | 9.466987e+01 | -2.418646e+00 | 1.898177e-13 | 3.792841e-11 |
| CB | DOWN | ENST00000637087.1 | TMEM198B-212:lncRNA:TMEM198B | 1.570866e+00 | -9.488949e-01 | 1.258068e-02 | 4.189017e-02 |
| TC | DOWN | ENST00000471276.5 | TMEM198B-201:lncRNA:TMEM198B | 1.393054e+02 | -1.134283e+00 | 1.099491e-07 | 6.592918e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM198B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103136 | chr12 | 55831035:55831083:55831257:55831349:55832959:55833014 | 55831257:55831349 |
| exon_skip_106202 | chr12 | 55832959:55833541:55834569:55834726:55834851:55834949 | 55834569:55834726 |
| exon_skip_136071 | chr12 | 55832959:55833541:55834569:55834726:55834851:55834938 | 55834569:55834726 |
| exon_skip_13742 | chr12 | 55830854:55831083:55831257:55831349:55833447:55833521 | 55831257:55831349 |
| exon_skip_138125 | chr12 | 55831035:55831083:55831257:55831349:55833447:55833521 | 55831257:55831349 |
| exon_skip_160207 | chr12 | 55830854:55831083:55832959:55833014:55833447:55833521 | 55832959:55833014 |
| exon_skip_184220 | chr12 | 55831297:55831349:55832959:55833125:55833447:55833541 | 55832959:55833125 |
| exon_skip_187996 | chr12 | 55833447:55833541:55834851:55835615:55836126:55836246 | 55834851:55835615 |
| exon_skip_188355 | chr12 | 55831297:55831349:55832871:55833014:55833447:55833541 | 55832871:55833014 |
| exon_skip_191842 | chr12 | 55832959:55833541:55834569:55834726:55834851:55834988 | 55834569:55834726 |
| exon_skip_192342 | chr12 | 55832959:55833038:55833447:55833541:55834851:55834988 | 55833447:55833541 |
| exon_skip_195283 | chr12 | 55831257:55831349:55832871:55833014:55833447:55833521 | 55832871:55833014 |
| exon_skip_199096 | chr12 | 55831035:55831083:55832959:55833038:55833447:55833521 | 55832959:55833038 |
| exon_skip_201928 | chr12 | 55831297:55831349:55832959:55833014:55833447:55833541 | 55832959:55833014 |
| exon_skip_202236 | chr12 | 55831297:55831349:55832959:55833038:55833447:55833541 | 55832959:55833038 |
| exon_skip_217365 | chr12 | 55831035:55831083:55831257:55831349:55832871:55833014 | 55831257:55831349 |
| exon_skip_24350 | chr12 | 55830854:55831083:55831257:55831349:55832959:55833014 | 55831257:55831349 |
| exon_skip_250598 | chr12 | 55831257:55831349:55832959:55833125:55833447:55833521 | 55832959:55833125 |
| exon_skip_254760 | chr12 | 55830854:55831083:55832959:55833038:55833447:55833521 | 55832959:55833038 |
| exon_skip_264617 | chr12 | 55831035:55831083:55832959:55833014:55833447:55833521 | 55832959:55833014 |
| exon_skip_284927 | chr12 | 55833437:55833541:55834569:55834726:55834851:55834949 | 55834569:55834726 |
| exon_skip_3197 | chr12 | 55831257:55831349:55832959:55833038:55833447:55833521 | 55832959:55833038 |
| exon_skip_66981 | chr12 | 55830854:55831083:55831257:55831349:55833447:55833541 | 55831257:55831349 |
| exon_skip_70316 | chr12 | 55831257:55831349:55832959:55833014:55833447:55833521 | 55832959:55833014 |
| exon_skip_71631 | chr12 | 55830854:55831083:55831257:55831349:55832871:55833014 | 55831257:55831349 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_187996 | Mayo_TC | 4.453521e-01 | 5.658209e-01 | -1.204688e-01 | 4.795079e-03 |
| exon_skip_284968 | Mayo_TC | 4.346053e-01 | 5.708955e-01 | -1.362903e-01 | 1.130994e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for TMEM198B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TMEM198B |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TMEM198B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TMEM198B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TMEM198B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM198B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TMEM198B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | RBM3 | exon_skip_187996 | 4.036627e-01 | 9.136414e-07 |
| TC | RBM3 | exon_skip_284968 | 5.774053e-01 | 4.383823e-14 |
| TC | PCBP4 | exon_skip_284968 | 4.756518e-01 | 1.931934e-09 |
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RelatedDrugs for TMEM198B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM198B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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