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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ASNS |
Gene summary |
Gene information | Gene symbol | ASNS | Gene ID | 440 |
Gene name | asparagine synthetase (glutamine-hydrolyzing) | |
Synonyms | ASNSD|TS11 | |
Cytomap | 7q21.3 | |
Type of gene | protein-coding | |
Description | asparagine synthetase [glutamine-hydrolyzing]TS11 cell cycle control proteinglutamine-dependent asparagine synthetase | |
Modification date | 20200313 | |
UniProtAcc | C9J057, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ASNS | GO:0006529 | asparagine biosynthetic process | 2573597 |
ASNS | GO:0042149 | cellular response to glucose starvation | 10085239 |
ASNS | GO:0045931 | positive regulation of mitotic cell cycle | 2569668 |
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Gene structures and expression levels for ASNS |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000487714.1 | ASNS-216:retained_intron:ASNS | 1.455887e+02 | -8.534545e-01 | 2.356297e-08 | 6.238600e-07 |
CB | DOWN | ENST00000437628.5 | ASNS-206:protein_coding:ASNS | 5.572355e+02 | -1.635817e+00 | 3.178820e-03 | 1.353889e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ASNS |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_230440 | chr7 | 97869778:97869813:97871719:97871996:97872351:97872408 | 97871719:97871996 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ASNS |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000175506 | 97871719 | 97871996 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000175506 | 97871719 | 97871996 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000175506 | 97871719 | 97871996 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ASNS |
p-ENSG00000070669_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ASNS |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4696 | chr7:97871758-97871765 | 8mer-1a | chr7:97871751-97871768 | 156.00 | -23.71 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-8072 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6862-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6865-3p | chr7:97871819-97871826 | 8mer-1a | chr7:97871819-97871839 | 163.00 | -29.36 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6784-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3138 | chr7:97871987-97871994 | 8mer-1a | chr7:97871968-97871994 | 143.00 | -27.78 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3934-5p | chr7:97871919-97871926 | 8mer-1a | chr7:97871916-97871938 | 157.00 | -29.23 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-593-3p | chr7:97871771-97871778 | 8mer-1a | chr7:97871771-97871795 | 151.00 | -31.70 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4663 | chr7:97871737-97871744 | 8mer-1a | chr7:97871723-97871751 | 147.00 | -23.23 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-1204 | chr7:97871936-97871943 | 8mer-1a | chr7:97871923-97871943 | 151.00 | -20.48 |
Mayo | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3960 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4696 | chr7:97871758-97871765 | 8mer-1a | chr7:97871751-97871768 | 156.00 | -23.71 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-8072 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6862-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6865-3p | chr7:97871819-97871826 | 8mer-1a | chr7:97871819-97871839 | 163.00 | -29.36 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6784-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3138 | chr7:97871987-97871994 | 8mer-1a | chr7:97871968-97871994 | 143.00 | -27.78 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3934-5p | chr7:97871919-97871926 | 8mer-1a | chr7:97871916-97871938 | 157.00 | -29.23 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-593-3p | chr7:97871771-97871778 | 8mer-1a | chr7:97871771-97871795 | 151.00 | -31.70 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4663 | chr7:97871737-97871744 | 8mer-1a | chr7:97871723-97871751 | 147.00 | -23.23 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-1204 | chr7:97871936-97871943 | 8mer-1a | chr7:97871923-97871943 | 151.00 | -20.48 |
MSBB | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3960 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4696 | chr7:97871758-97871765 | 8mer-1a | chr7:97871751-97871768 | 156.00 | -23.71 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-8072 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6862-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6865-3p | chr7:97871819-97871826 | 8mer-1a | chr7:97871819-97871839 | 163.00 | -29.36 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-6784-3p | chr7:97871802-97871809 | 8mer-1a | chr7:97871788-97871810 | 170.00 | -37.28 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3138 | chr7:97871987-97871994 | 8mer-1a | chr7:97871968-97871994 | 143.00 | -27.78 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3934-5p | chr7:97871919-97871926 | 8mer-1a | chr7:97871916-97871938 | 157.00 | -29.23 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-593-3p | chr7:97871771-97871778 | 8mer-1a | chr7:97871771-97871795 | 151.00 | -31.70 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-4663 | chr7:97871737-97871744 | 8mer-1a | chr7:97871723-97871751 | 147.00 | -23.23 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-1204 | chr7:97871936-97871943 | 8mer-1a | chr7:97871923-97871943 | 151.00 | -20.48 |
ROSMAP | ENST00000175506 | 97871719 | 97871996 | hsa-miR-3960 | chr7:97871960-97871967 | 8mer-1a | chr7:97871948-97871967 | 155.00 | -31.42 |
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SNVs in the skipped exons for ASNS |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ASNS |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ASNS |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
CB | exon_skip_230440 | rs3757674 | chr7:97873828 | 5.919124e-05 | 1.139971e-02 |
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Correlation with RNA binding proteins (RBPs) for ASNS |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ASNS |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P08243 | approved|nutraceutical | DB00142 | Glutamic Acid | small molecule | P08243 |
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RelatedDiseases for ASNS |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |