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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MOG |
Gene summary |
Gene information | Gene symbol | MOG | Gene ID | 4340 |
Gene name | myelin oligodendrocyte glycoprotein | |
Synonyms | BTN6|BTNL11|MOGIG2|NRCLP7 | |
Cytomap | 6p22.1 | |
Type of gene | protein-coding | |
Description | myelin-oligodendrocyte glycoproteinMOG AluAMOG AluBMOG Ig-AluBMOG alpha-5 | |
Modification date | 20200313 | |
UniProtAcc | A0A0G2JHA9, A0A0G2JHB7, A0A0G2JHM8, A0A0G2JI49, | |
Context | - 32255227(White matter alterations in Alzheimer's disease without concomitant pathologies) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MOG |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | DOWN | ENST00000376903.4 | MOG-220:nonsense_mediated_decay:MOG | 3.512088e+01 | -1.027542e+00 | 7.637000e-05 | 1.304016e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MOG |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109279 | chr6 | 29670174:29670221:29670701:29670721:29671422:29671718 | 29670701:29670721 |
exon_skip_115983 | chr6 | 29659646:29659666:29664630:29664767:29666152:29666260 | 29664630:29664767 |
exon_skip_118907 | chr6 | 29657210:29657297:29659319:29659666:29666152:29666265 | 29659319:29659666 |
exon_skip_12824 | chr6 | 29667904:29667924:29670701:29670721:29671422:29671718 | 29670701:29670721 |
exon_skip_170595 | chr6 | 29667904:29667924:29670281:29670397:29670701:29670721 | 29670281:29670397 |
exon_skip_196326 | chr6 | 29667906:29667924:29670174:29670221:29670701:29670721 | 29670174:29670221 |
exon_skip_202746 | chr6 | 29667906:29667924:29670281:29670397:29670701:29670721 | 29670281:29670397 |
exon_skip_21247 | chr6 | 29659473:29659666:29664630:29664767:29666152:29666260 | 29664630:29664767 |
exon_skip_261091 | chr6 | 29667904:29667924:29670174:29670221:29670701:29670721 | 29670174:29670221 |
exon_skip_30626 | chr6 | 29667904:29667924:29670701:29670721:29671422:29671564 | 29670701:29670721 |
exon_skip_44441 | chr6 | 29657216:29657297:29659319:29659666:29666152:29666260 | 29659319:29659666 |
exon_skip_79029 | chr6 | 29659324:29659666:29664630:29664767:29666152:29666260 | 29664630:29664767 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MOG |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MOG |
p-ENSG00000204655_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MOG |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MOG |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MOG |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MOG |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MOG |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MOG |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MOG |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |