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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MOBP |
 Gene summary |
| Gene information | Gene symbol | MOBP | Gene ID | 4336 |
| Gene name | myelin associated oligodendrocyte basic protein | |
| Synonyms | - | |
| Cytomap | 3p22.1 | |
| Type of gene | protein-coding | |
| Description | myelin-associated oligodendrocyte basic protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 23116876(An Exploratory Study on STX6, MOBP, MAPT, and EIF2AK3 and Late-Onset Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MOBP |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000168314
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| CB | DOWN | 4.358845e+03 | -8.159286e-01 | 4.537743e-06 | 3.883118e-05 |
| TC | DOWN | 2.579159e+04 | -1.262323e+00 | 1.079156e-13 | 2.268846e-11 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000442631.5 | MOBP-209:nonsense_mediated_decay:MOBP | 1.298835e+01 | 1.933682e+00 | 8.801401e-04 | 3.582609e-02 |
| CB | DOWN | ENST00000452959.6 | MOBP-212:nonsense_mediated_decay:MOBP | 4.123838e+03 | -1.468573e+00 | 9.230438e-12 | 9.110343e-10 |
| CB | DOWN | ENST00000442631.5 | MOBP-209:nonsense_mediated_decay:MOBP | 2.717297e+01 | -1.550279e+00 | 1.179100e-10 | 7.227353e-09 |
| CB | DOWN | ENST00000441980.6 | MOBP-208:protein_coding:MOBP | 2.575288e+01 | -1.064487e+00 | 1.047746e-07 | 2.209913e-06 |
| CB | DOWN | ENST00000424090.5 | MOBP-205:nonsense_mediated_decay:MOBP | 2.481924e+02 | -1.069623e+00 | 1.242089e-07 | 2.554161e-06 |
| CB | DOWN | ENST00000428261.5 | MOBP-206:protein_coding:MOBP | 5.687225e+01 | -1.117380e+00 | 5.574222e-07 | 9.121476e-06 |
| CB | DOWN | ENST00000420739.5 | MOBP-204:protein_coding:MOBP | 4.149327e+01 | -1.169673e+00 | 2.233215e-06 | 2.968590e-05 |
| CB | DOWN | ENST00000311042.10 | MOBP-201:protein_coding:MOBP | 3.859427e+01 | -1.487008e+00 | 1.225167e-05 | 1.250055e-04 |
| CB | DOWN | ENST00000479860.1 | MOBP-213:lncRNA:MOBP | 2.782300e+00 | -1.341715e+00 | 4.470748e-04 | 2.620812e-03 |
| TC | DOWN | ENST00000452959.6 | MOBP-212:nonsense_mediated_decay:MOBP | 1.858678e+04 | -1.571625e+00 | 4.238421e-18 | 7.571692e-15 |
| TC | DOWN | ENST00000311042.10 | MOBP-201:protein_coding:MOBP | 1.937775e+02 | -1.348901e+00 | 8.643485e-15 | 6.097247e-12 |
| TC | DOWN | ENST00000442631.5 | MOBP-209:nonsense_mediated_decay:MOBP | 1.771144e+02 | -1.522034e+00 | 1.598247e-14 | 1.025403e-11 |
| TC | DOWN | ENST00000441980.6 | MOBP-208:protein_coding:MOBP | 1.755517e+02 | -1.257892e+00 | 2.901207e-14 | 1.676182e-11 |
| TC | DOWN | ENST00000420739.5 | MOBP-204:protein_coding:MOBP | 1.609127e+02 | -1.453316e+00 | 3.049966e-14 | 1.748088e-11 |
| TC | DOWN | ENST00000428261.5 | MOBP-206:protein_coding:MOBP | 3.128800e+02 | -1.402931e+00 | 2.112385e-13 | 9.653529e-11 |
| TC | DOWN | ENST00000424090.5 | MOBP-205:nonsense_mediated_decay:MOBP | 1.431349e+03 | -1.151506e+00 | 2.710654e-10 | 4.519597e-08 |
| TC | DOWN | ENST00000479860.1 | MOBP-213:lncRNA:MOBP | 1.149935e+01 | -1.085405e+00 | 1.144536e-06 | 4.473937e-05 |
| TC | DOWN | ENST00000436143.6 | MOBP-207:protein_coding:MOBP | 6.365102e+00 | -1.094313e+00 | 3.476423e-06 | 1.114952e-04 |
| TC | DOWN | ENST00000415443.5 | MOBP-203:protein_coding:MOBP | 8.420473e+00 | -1.156605e+00 | 2.296929e-04 | 3.121482e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MOBP |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100545 | chr3 | 39467704:39467740:39499467:39499532:39502066:39502075 | 39499467:39499532 |
| exon_skip_138438 | chr3 | 39480040:39480123:39499467:39499532:39502066:39502224 | 39499467:39499532 |
| exon_skip_141645 | chr3 | 39502215:39502275:39502463:39502876:39513383:39513447 | 39502463:39502876 |
| exon_skip_161145 | chr3 | 39467704:39467740:39480040:39480123:39502066:39502224 | 39480040:39480123 |
| exon_skip_162036 | chr3 | 39480042:39480123:39499467:39499532:39502066:39502224 | 39499467:39499532 |
| exon_skip_163384 | chr3 | 39480055:39480123:39502066:39502275:39513383:39513447 | 39502066:39502275 |
| exon_skip_167017 | chr3 | 39467704:39467740:39480040:39480123:39499467:39499532 | 39480040:39480123 |
| exon_skip_174140 | chr3 | 39502265:39502275:39502535:39502876:39513383:39513447 | 39502535:39502876 |
| exon_skip_174692 | chr3 | 39513383:39513606:39517723:39517785:39524243:39524326 | 39517723:39517785 |
| exon_skip_199135 | chr3 | 39467704:39467740:39502066:39502275:39513383:39513447 | 39502066:39502275 |
| exon_skip_223495 | chr3 | 39467704:39467740:39480040:39480123:39502066:39502075 | 39480040:39480123 |
| exon_skip_224691 | chr3 | 39502215:39502275:39502535:39502914:39513383:39513447 | 39502535:39502914 |
| exon_skip_240173 | chr3 | 39513383:39513606:39524243:39524326:39524444:39524494 | 39524243:39524326 |
| exon_skip_280043 | chr3 | 39480040:39480123:39502066:39502275:39513383:39513447 | 39502066:39502275 |
| exon_skip_296334 | chr3 | 39499467:39499532:39499867:39500067:39502066:39502224 | 39499867:39500067 |
| exon_skip_4180 | chr3 | 39502215:39502275:39502535:39502876:39513383:39513447 | 39502535:39502876 |
| exon_skip_52571 | chr3 | 39513383:39513606:39524243:39524326:39524444:39524457 | 39524243:39524326 |
| exon_skip_56950 | chr3 | 39480040:39480123:39499467:39499532:39502066:39502075 | 39499467:39499532 |
| exon_skip_57809 | chr3 | 39502265:39502275:39502535:39502914:39513383:39513447 | 39502535:39502914 |
| exon_skip_61821 | chr3 | 39467704:39467740:39499467:39499532:39502066:39502224 | 39499467:39499532 |
| exon_skip_90213 | chr3 | 39502265:39502275:39502463:39502876:39513383:39513447 | 39502463:39502876 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MOBP |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000420739 | 39502535 | 39502914 | 3UTR-3CDS |
| ENST00000420739 | 39480040 | 39480123 | 5UTR-5UTR |
| ENST00000441980 | 39499467 | 39499532 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000420739 | 39502535 | 39502914 | 3UTR-3CDS |
| ENST00000420739 | 39480040 | 39480123 | 5UTR-5UTR |
| ENST00000441980 | 39499467 | 39499532 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000420739 | 39502535 | 39502914 | 3UTR-3CDS |
| ENST00000420739 | 39480040 | 39480123 | 5UTR-5UTR |
| ENST00000441980 | 39499467 | 39499532 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for MOBP |
p-ENSG00000168314_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MOBP |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MOBP |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MOBP |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_280043 | -3.750282e-01 | 4.924894e-02 | chr3 | + | 39480040 | 39480123 | 39502066 | 39502275 | 39513383 | 39513447 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MOBP |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MOBP |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | PCBP4 | exon_skip_138438 | 4.302577e-01 | 7.629577e-17 |
| FL | SRSF2 | exon_skip_224691 | -4.260783e-01 | 3.511019e-10 |
| FL | SRSF11 | exon_skip_224691 | -4.729748e-01 | 1.736498e-12 |
| FL | MBNL1 | exon_skip_224691 | -4.184910e-01 | 7.699426e-10 |
| FL | TRNAU1AP | exon_skip_224691 | -4.474396e-01 | 3.456611e-11 |
| FL | FUBP1 | exon_skip_224691 | -5.425115e-01 | 1.266507e-16 |
| FL | RALYL | exon_skip_224691 | -4.612937e-01 | 7.035030e-12 |
| FL | CELF1 | exon_skip_224691 | -4.076707e-01 | 2.282126e-09 |
| HCC | SRSF2 | exon_skip_224691 | -4.091464e-01 | 1.926070e-12 |
| HCC | PCBP4 | exon_skip_224691 | -4.218798e-01 | 3.305102e-13 |
| PG | SRSF2 | exon_skip_224691 | -4.563627e-01 | 3.797097e-12 |
| PG | SRSF11 | exon_skip_224691 | -5.032600e-01 | 8.092996e-15 |
| PG | RBM5 | exon_skip_224691 | -5.055237e-01 | 5.868849e-15 |
| PG | TRNAU1AP | exon_skip_224691 | -5.402769e-01 | 3.095691e-17 |
| PG | HNRNPK | exon_skip_224691 | -4.016533e-01 | 1.664563e-09 |
| PG | PCBP2 | exon_skip_224691 | -5.541505e-01 | 3.204456e-18 |
| PG | FUBP1 | exon_skip_224691 | -6.492696e-01 | 2.101980e-26 |
| PG | EIF4G2 | exon_skip_224691 | -4.165031e-01 | 3.551577e-10 |
| PG | CELF1 | exon_skip_224691 | -4.497717e-01 | 8.381091e-12 |
| PG | NOVA1 | exon_skip_224691 | -4.353149e-01 | 4.488872e-11 |
| PG | RBM4 | exon_skip_224691 | -5.115154e-01 | 2.478318e-15 |
| STG | SRSF2 | exon_skip_224691 | -4.431510e-01 | 8.650117e-06 |
| STG | RBM6 | exon_skip_224691 | -5.656155e-01 | 3.473221e-09 |
| STG | SRSF11 | exon_skip_224691 | -6.211800e-01 | 3.068196e-11 |
| STG | CNOT4 | exon_skip_224691 | -4.611791e-01 | 3.282651e-06 |
| STG | RBM5 | exon_skip_224691 | -5.928104e-01 | 3.839640e-10 |
| STG | MBNL1 | exon_skip_224691 | -4.929696e-01 | 5.167243e-07 |
| STG | TRNAU1AP | exon_skip_224691 | -5.209094e-01 | 8.657865e-08 |
| STG | HNRNPK | exon_skip_224691 | -4.059243e-01 | 5.416537e-05 |
| STG | PCBP2 | exon_skip_224691 | -5.986437e-01 | 2.330113e-10 |
| STG | FUBP1 | exon_skip_224691 | -5.521266e-01 | 9.635244e-09 |
| STG | RALYL | exon_skip_224691 | -4.053250e-01 | 5.569244e-05 |
| STG | EIF4G2 | exon_skip_224691 | -4.618381e-01 | 3.165088e-06 |
| STG | CELF1 | exon_skip_224691 | -5.985008e-01 | 2.359077e-10 |
| STG | NOVA1 | exon_skip_224691 | -4.743668e-01 | 1.559171e-06 |
| STG | RBM4 | exon_skip_224691 | -4.778411e-01 | 1.274817e-06 |
| TC | PCBP4 | exon_skip_56950 | 4.322042e-01 | 1.149994e-08 |
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RelatedDrugs for MOBP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MOBP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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