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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MLF1 |
 Gene summary |
| Gene information | Gene symbol | MLF1 | Gene ID | 4291 |
| Gene name | myeloid leukemia factor 1 | |
| Synonyms | - | |
| Cytomap | 3q25.32 | |
| Type of gene | protein-coding | |
| Description | myeloid leukemia factor 1myelodysplasia-myeloid leukemia factor 1testis tissue sperm-binding protein Li 49e | |
| Modification date | 20200318 | |
| UniProtAcc | A0A0S2Z4A4, A0A0S2Z4B4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MLF1 | GO:0007050 | cell cycle arrest | 15861129 |
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Gene structures and expression levels for MLF1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000178053
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000651984.1 | MLF1-221:protein_coding:MLF1 | 8.198692e+00 | 1.218036e+00 | 1.029141e-04 | 7.589065e-04 |
| CB | UP | ENST00000477042.6 | MLF1-207:protein_coding:MLF1 | 3.384704e+00 | 4.291508e+00 | 5.214351e-04 | 2.986508e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MLF1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104554 | chr3 | 158571261:158571347:158592434:158592581:158596862:158596945 | 158592434:158592581 |
| exon_skip_115630 | chr3 | 158571254:158571347:158582656:158582929:158592434:158592581 | 158582656:158582929 |
| exon_skip_124873 | chr3 | 158571194:158571391:158582656:158582929:158592434:158592581 | 158582656:158582929 |
| exon_skip_151267 | chr3 | 158571206:158571391:158592434:158592581:158596862:158596945 | 158592434:158592581 |
| exon_skip_165790 | chr3 | 158571206:158571391:158582656:158582929:158592434:158592581 | 158582656:158582929 |
| exon_skip_258358 | chr3 | 158571261:158571347:158582656:158582929:158592434:158592581 | 158582656:158582929 |
| exon_skip_42908 | chr3 | 158571261:158571347:158588860:158588924:158592434:158592581 | 158588860:158588924 |
| exon_skip_48865 | chr3 | 158571206:158571391:158588852:158588924:158592434:158592581 | 158588852:158588924 |
| exon_skip_62457 | chr3 | 158571261:158571347:158572976:158573039:158596862:158596945 | 158572976:158573039 |
| exon_skip_69069 | chr3 | 158571261:158571347:158588852:158588924:158592434:158592581 | 158588852:158588924 |
| exon_skip_69124 | chr3 | 158571194:158571347:158588860:158588924:158592434:158592581 | 158588860:158588924 |
| exon_skip_7763 | chr3 | 158600014:158600173:158602807:158602939:158605097:158605218 | 158602807:158602939 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MLF1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355893 | 158592434 | 158592581 | Frame-shift |
| ENST00000355893 | 158602807 | 158602939 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355893 | 158592434 | 158592581 | Frame-shift |
| ENST00000355893 | 158602807 | 158602939 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355893 | 158592434 | 158592581 | Frame-shift |
| ENST00000355893 | 158602807 | 158602939 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MLF1 |
p-ENSG00000178053_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MLF1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MLF1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MLF1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MLF1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_48865 | rs4680449 | chr3:158632329 | 1.063400e-06 | 3.729253e-04 |
| CB | exon_skip_48865 | rs8455 | chr3:158670991 | 1.063400e-06 | 3.729253e-04 |
| CB | exon_skip_69069 | rs4680449 | chr3:158632329 | 1.547681e-06 | 5.196281e-04 |
| CB | exon_skip_69069 | rs8455 | chr3:158670991 | 1.547681e-06 | 5.196281e-04 |
| CB | exon_skip_104554 | rs16829102 | chr3:158538339 | 1.527505e-04 | 2.420345e-02 |
| TC | exon_skip_48865 | rs4680449 | chr3:158632329 | 1.640382e-11 | 1.891597e-08 |
| TC | exon_skip_48865 | rs8455 | chr3:158670991 | 1.640382e-11 | 1.891597e-08 |
| TC | exon_skip_69069 | rs4680449 | chr3:158632329 | 1.777554e-09 | 1.257487e-06 |
| TC | exon_skip_69069 | rs8455 | chr3:158670991 | 1.777554e-09 | 1.257487e-06 |
| TC | exon_skip_48865 | rs2566332 | chr3:158625139 | 1.350942e-07 | 5.779044e-05 |
| TC | exon_skip_48865 | rs1656377 | chr3:158567491 | 2.257129e-06 | 7.024705e-04 |
| TC | exon_skip_48865 | rs7638518 | chr3:158568953 | 2.763464e-04 | 3.672848e-02 |
| TC | exon_skip_48865 | rs10513527 | chr3:158583893 | 2.763464e-04 | 3.672848e-02 |
| TC | exon_skip_48865 | rs13315529 | chr3:158610485 | 2.763464e-04 | 3.672848e-02 |
| TC | exon_skip_48865 | rs17630394 | chr3:158668007 | 2.763464e-04 | 3.672848e-02 |
| HCC | exon_skip_48865 | rs4680449 | chr3:158632329 | 7.042814e-09 | 1.788793e-06 |
| HCC | exon_skip_48865 | rs8455 | chr3:158670991 | 1.161952e-08 | 2.820229e-06 |
| HCC | exon_skip_48865 | rs891464 | chr3:158664304 | 1.205595e-08 | 2.914742e-06 |
| HCC | exon_skip_69069 | rs4680449 | chr3:158632329 | 3.189079e-08 | 7.113520e-06 |
| HCC | exon_skip_69069 | rs891464 | chr3:158664304 | 8.415974e-08 | 1.713794e-05 |
| HCC | exon_skip_69069 | rs8455 | chr3:158670991 | 1.110561e-07 | 2.200054e-05 |
| HCC | exon_skip_48865 | rs1435642 | chr3:158582432 | 3.314153e-07 | 5.967707e-05 |
| HCC | exon_skip_48865 | rs2566334 | chr3:158624715 | 5.040047e-07 | 8.810936e-05 |
| HCC | exon_skip_48865 | rs2566332 | chr3:158625139 | 8.608425e-07 | 1.423909e-04 |
| HCC | exon_skip_48865 | rs1656377 | chr3:158567491 | 5.561725e-06 | 7.525714e-04 |
| HCC | exon_skip_48865 | rs4510417 | chr3:158491764 | 9.888491e-06 | 1.239692e-03 |
| HCC | exon_skip_69069 | rs1435642 | chr3:158582432 | 1.733029e-05 | 2.041203e-03 |
| HCC | exon_skip_48865 | rs9832803 | chr3:158673335 | 2.387850e-05 | 2.686523e-03 |
| HCC | exon_skip_48865 | rs7648618 | chr3:158505049 | 2.390474e-05 | 2.687036e-03 |
| HCC | exon_skip_48865 | rs9858318 | chr3:158505502 | 2.390474e-05 | 2.687036e-03 |
| HCC | exon_skip_48865 | rs9883657 | chr3:158508210 | 2.390474e-05 | 2.687036e-03 |
| HCC | exon_skip_69069 | rs2566334 | chr3:158624715 | 3.897661e-05 | 4.068788e-03 |
| HCC | exon_skip_69069 | rs9832803 | chr3:158673335 | 5.676610e-05 | 5.627259e-03 |
| HCC | exon_skip_48865 | rs7638518 | chr3:158568953 | 7.405634e-05 | 7.086216e-03 |
| HCC | exon_skip_48865 | rs10513527 | chr3:158583893 | 7.405634e-05 | 7.086216e-03 |
| HCC | exon_skip_48865 | rs2082838 | chr3:158588105 | 7.405634e-05 | 7.086216e-03 |
| HCC | exon_skip_48865 | rs9812307 | chr3:158491696 | 8.073896e-05 | 7.637216e-03 |
| HCC | exon_skip_69069 | rs2566332 | chr3:158625139 | 1.230125e-04 | 1.093756e-02 |
| HCC | exon_skip_48865 | rs17630223 | chr3:158661383 | 1.426573e-04 | 1.232386e-02 |
| HCC | exon_skip_48865 | rs13315529 | chr3:158610485 | 2.097174e-04 | 1.686442e-02 |
| HCC | exon_skip_48865 | rs16829079 | chr3:158533813 | 2.971578e-04 | 2.238097e-02 |
| HCC | exon_skip_48865 | rs16829273 | chr3:158664831 | 8.193127e-04 | 4.991029e-02 |
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Correlation with RNA binding proteins (RBPs) for MLF1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MLF1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MLF1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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