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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MGST3 |
 Gene summary |
| Gene information | Gene symbol | MGST3 | Gene ID | 4259 |
| Gene name | microsomal glutathione S-transferase 3 | |
| Synonyms | GST-III | |
| Cytomap | 1q24.1 | |
| Type of gene | protein-coding | |
| Description | microsomal glutathione S-transferase 3LTC4 synthase MGST3glutathione peroxidase MGST3microsomal GST-3microsomal GST-IIImicrosomal glutathione S-transferase III | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 25280473(Joint Genetic Analysis of Hippocampal Size in Mouse and Human Identifies a Novel Gene Linked to Neurodegenerative Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MGST3 | GO:0006629 | lipid metabolic process | 9278457 |
| MGST3 | GO:0019370 | leukotriene biosynthetic process | 9278457 |
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Gene structures and expression levels for MGST3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000143198
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MGST3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12840 | chr1 | 165649841:165649964:165651014:165651087:165651978:165652035 | 165651014:165651087 |
| exon_skip_142129 | chr1 | 165651978:165652035:165654279:165654351:165655368:165655412 | 165654279:165654351 |
| exon_skip_172870 | chr1 | 165631258:165631293:165649755:165649964:165651014:165651087 | 165649755:165649964 |
| exon_skip_18218 | chr1 | 165652013:165652035:165654279:165654351:165655368:165655617 | 165654279:165654351 |
| exon_skip_183222 | chr1 | 165649933:165649964:165651014:165651087:165651978:165652035 | 165651014:165651087 |
| exon_skip_219432 | chr1 | 165651014:165651087:165651978:165652035:165654279:165654351 | 165651978:165652035 |
| exon_skip_233645 | chr1 | 165631258:165631293:165632231:165632274:165649841:165649884 | 165632231:165632274 |
| exon_skip_260678 | chr1 | 165651031:165651087:165651978:165652035:165654279:165654351 | 165651978:165652035 |
| exon_skip_284414 | chr1 | 165631258:165631293:165649841:165649964:165651014:165651087 | 165649841:165649964 |
| exon_skip_28864 | chr1 | 165651978:165652035:165654279:165654351:165655368:165655617 | 165654279:165654351 |
| exon_skip_295756 | chr1 | 165631258:165631293:165632231:165632274:165649841:165649964 | 165632231:165632274 |
| exon_skip_77324 | chr1 | 165649930:165649964:165651014:165651087:165651978:165652035 | 165651014:165651087 |
| exon_skip_82396 | chr1 | 165649848:165649964:165651014:165651087:165651978:165652035 | 165651014:165651087 |
| exon_skip_97337 | chr1 | 165631258:165631293:165632231:165632274:165649841:165649868 | 165632231:165632274 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MGST3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367889 | 165649841 | 165649964 | 5CDS-5UTR |
| ENST00000367884 | 165651014 | 165651087 | Frame-shift |
| ENST00000367889 | 165651014 | 165651087 | Frame-shift |
| ENST00000367884 | 165651978 | 165652035 | Frame-shift |
| ENST00000367889 | 165651978 | 165652035 | Frame-shift |
| ENST00000367884 | 165654279 | 165654351 | Frame-shift |
| ENST00000367889 | 165654279 | 165654351 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367884 | 165651014 | 165651087 | Frame-shift |
| ENST00000367889 | 165651014 | 165651087 | Frame-shift |
| ENST00000367884 | 165651978 | 165652035 | Frame-shift |
| ENST00000367889 | 165651978 | 165652035 | Frame-shift |
| ENST00000367884 | 165654279 | 165654351 | Frame-shift |
| ENST00000367889 | 165654279 | 165654351 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367889 | 165649841 | 165649964 | 5CDS-5UTR |
| ENST00000367884 | 165651014 | 165651087 | Frame-shift |
| ENST00000367889 | 165651014 | 165651087 | Frame-shift |
| ENST00000367884 | 165651978 | 165652035 | Frame-shift |
| ENST00000367889 | 165651978 | 165652035 | Frame-shift |
| ENST00000367884 | 165654279 | 165654351 | Frame-shift |
| ENST00000367889 | 165654279 | 165654351 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MGST3 |
p-ENSG00000143198_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MGST3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MGST3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MGST3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | STG | exon_skip_97337 | -3.266174e-01 | 1.396871e-03 | chr1 | + | 165631258 | 165631293 | 165632231 | 165632274 | 165649841 | 165649868 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MGST3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MGST3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MGST3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O14880 | approved|investigational|nutraceutical | DB00143 | Glutathione | small molecule | O14880 |
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RelatedDiseases for MGST3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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