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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MET |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MET | GO:0001886 | endothelial cell morphogenesis | 14500721 |
| MET | GO:0035024 | negative regulation of Rho protein signal transduction | 25198505 |
| MET | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22521434 |
| MET | GO:0050918 | positive chemotaxis | 15218527 |
| MET | GO:0051497 | negative regulation of stress fiber assembly | 25198505 |
| MET | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway | 25198505 |
| MET | GO:0071526 | semaphorin-plexin signaling pathway | 15218527 |
| MET | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity | 25198505 |
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Gene structures and expression levels for MET |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000105976
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000318493.11 | MET-201:protein_coding:MET | 1.792197e+00 | 4.134321e+00 | 4.678261e-03 | 1.863589e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MET |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_128004 | chr7 | 116672392:116672577:116699071:116700284:116731668:116731859 | 116699071:116700284 |
| exon_skip_191695 | chr7 | 116672392:116672577:116695750:116695799:116699071:116699599 | 116695750:116695799 |
| exon_skip_216784 | chr7 | 116758517:116758620:116759337:116759490:116763050:116763080 | 116759337:116759490 |
| exon_skip_248797 | chr7 | 116672390:116672577:116695750:116695799:116699071:116699599 | 116695750:116695799 |
| exon_skip_257363 | chr7 | 116758517:116758620:116759391:116759490:116763050:116763080 | 116759391:116759490 |
| exon_skip_258249 | chr7 | 116771498:116771654:116771849:116771989:116774881:116775072 | 116771849:116771989 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MET |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397752 | 116699071 | 116700284 | 5CDS-5UTR |
| ENST00000397752 | 116759391 | 116759490 | Frame-shift |
| ENST00000397752 | 116771849 | 116771989 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397752 | 116699071 | 116700284 | 5CDS-5UTR |
| ENST00000397752 | 116759391 | 116759490 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397752 | 116699071 | 116700284 | 5CDS-5UTR |
| ENST00000397752 | 116759391 | 116759490 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MET |
p-ENSG00000105976_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000397752 | 6652 | 1390 | 116771849 | 116771989 | 3089 | 3228 | 963 | 1009 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08581 | 963 | 1009 | 765 | 1390 | Alternative sequence | ID=VSP_042448;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464 |
| P08581 | 963 | 1009 | 25 | 1390 | Chain | ID=PRO_0000024440;Note=Hepatocyte growth factor receptor |
| P08581 | 963 | 1009 | 966 | 966 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| P08581 | 963 | 1009 | 977 | 977 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976 |
| P08581 | 963 | 1009 | 990 | 990 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| P08581 | 963 | 1009 | 997 | 997 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| P08581 | 963 | 1009 | 1000 | 1000 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| P08581 | 963 | 1009 | 1003 | 1003 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 |
| P08581 | 963 | 1009 | 964 | 1010 | Natural variant | ID=VAR_076584;Note=In OSFD%3B loss of CBL-mediated destabilization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26637977;Dbxref=PMID:26637977 |
| P08581 | 963 | 1009 | 970 | 970 | Natural variant | ID=VAR_032482;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17053076,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34589476,PMID:17053076,PMID:17344846 |
| P08581 | 963 | 1009 | 991 | 991 | Natural variant | ID=VAR_032483;Note=In gastric cancer%3B prolonged tyrosine phosphorylation in response to HGF/SF%3B transforming activity in athymic nude mice. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042681;Dbxref=dbSNP:rs768678989,PMID:11042681 |
| P08581 | 963 | 1009 | 992 | 992 | Natural variant | ID=VAR_032484;Note=Found in a case of cancer of unknown primary origin%3B the mutated receptor is still functional and can sustain the transformed phenotype%3B somatic mutation. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=E |
| P08581 | 963 | 1009 | 1003 | 1003 | Natural variant | ID=VAR_076585;Note=Probable disease-associated mutation found in lesional sample from a patient with sporadically occurring%2C unilateral osteofibrous dysplasia%3B somatic mutation%3B complete loss of ligand-induced CBL-mediated ubiquitination%2C resultin |
| P08581 | 963 | 1009 | 1003 | 1003 | Site | Note=Required for ligand-induced CBL-mediated ubiquitination;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12244174;Dbxref=PMID:12244174 |
| P08581 | 963 | 1009 | 1009 | 1010 | Site | Note=Breakpoint for translocation to form TPR-MET oncogene |
| P08581 | 963 | 1009 | 956 | 1390 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MET |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MET |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MET |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MET |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MET |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MET |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P08581 | approved | DB08865 | Crizotinib | small molecule | P08581 |
| P08581 | approved|investigational | DB08875 | Cabozantinib | small molecule | P08581 |
| P08581 | approved|investigational | DB12010 | Fostamatinib | small molecule | P08581 |
| P08581 | approved|investigational | DB12267 | Brigatinib | small molecule | P08581 |
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RelatedDiseases for MET |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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