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	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for MDK

Gene summary

Gene information	Gene symbol	MDK
	Gene ID	4192
	Gene name	midkine
	Synonyms	ARAP|MK|NEGF2
	Cytomap	11p11.2
	Type of gene	protein-coding
	Description	midkineamphiregulin-associated proteinmidgestation and kidney proteinneurite growth-promoting factor 2neurite outgrowth-promoting factor 2retinoic acid inducible factor
	Modification date	20200315
	UniProtAcc	A0A087WXB6, C9JHA4, E9PLM6, E9PPJ5, P21741, Q2LEK2, Q2LEK3,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MDK	GO:0010838	positive regulation of keratinocyte proliferation	18469519
MDK	GO:0010976	positive regulation of neuron projection development	12084985
MDK	GO:0030335	positive regulation of cell migration	15466886
MDK	GO:0043524	negative regulation of neuron apoptotic process	12573468
MDK	GO:0045785	positive regulation of cell adhesion	12084985
MDK	GO:0048714	positive regulation of oligodendrocyte differentiation	27445335
MDK	GO:2000249	regulation of actin cytoskeleton reorganization	18469519

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Gene structures and expression levels for MDK

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000110492

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
CB	DOWN	5.287841e+02	-1.197471e+00	1.762282e-12	1.765691e-10

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
DLPFC	DOWN	ENST00000395566.8	MDK-203:protein_coding:MDK	1.251917e+02	-8.048712e-01	3.351625e-12	1.888429e-08
PCC	DOWN	ENST00000395566.8	MDK-203:protein_coding:MDK	9.877421e+01	-8.204360e-01	2.814691e-09	4.057277e-06
CB	DOWN	ENST00000395566.8	MDK-203:protein_coding:MDK	4.177883e+02	-1.301742e+00	4.490792e-12	5.163236e-10
CB	DOWN	ENST00000407067.1	MDK-206:protein_coding:MDK	1.845413e+01	-8.218118e-01	4.844241e-04	2.804386e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MDK

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_133275	chr11	46381061:46381183:46382057:46382133:46382294:46382364	46382057:46382133
exon_skip_163666	chr11	46382057:46382133:46382294:46382461:46382587:46382748	46382294:46382461
exon_skip_204790	chr11	46381693:46381758:46382057:46382133:46382294:46382461	46382057:46382133
exon_skip_219982	chr11	46381693:46381758:46382057:46382133:46382294:46382364	46382057:46382133
exon_skip_253110	chr11	46382057:46382133:46382294:46382461:46382587:46382736	46382294:46382461

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for MDK

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000395566	46382057	46382133	5CDS-5UTR
ENST00000359803	46382294	46382461	In-frame
ENST00000395565	46382294	46382461	In-frame
ENST00000395566	46382294	46382461	In-frame
ENST00000405308	46382294	46382461	In-frame
ENST00000407067	46382294	46382461	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000395566	46382057	46382133	5CDS-5UTR
ENST00000359803	46382294	46382461	In-frame
ENST00000395565	46382294	46382461	In-frame
ENST00000395566	46382294	46382461	In-frame
ENST00000405308	46382294	46382461	In-frame
ENST00000407067	46382294	46382461	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000395566	46382057	46382133	5CDS-5UTR
ENST00000359803	46382294	46382461	In-frame
ENST00000395565	46382294	46382461	In-frame
ENST00000395566	46382294	46382461	In-frame
ENST00000405308	46382294	46382461	In-frame
ENST00000407067	46382294	46382461	In-frame

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Infer the effects of exon skipping event on protein functional features for MDK

p-ENSG00000110492_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359803	1002	143	46382294	46382461	300	466	26	81
ENST00000395565	968	143	46382294	46382461	254	420	26	81
ENST00000395566	845	143	46382294	46382461	162	328	26	81
ENST00000405308	1183	143	46382294	46382461	507	673	26	81
ENST00000407067	1043	143	46382294	46382461	383	549	26	81

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359803	1002	143	46382294	46382461	300	466	26	81
ENST00000395565	968	143	46382294	46382461	254	420	26	81
ENST00000395566	845	143	46382294	46382461	162	328	26	81
ENST00000405308	1183	143	46382294	46382461	507	673	26	81
ENST00000407067	1043	143	46382294	46382461	383	549	26	81

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359803	1002	143	46382294	46382461	300	466	26	81
ENST00000395565	968	143	46382294	46382461	254	420	26	81
ENST00000395566	845	143	46382294	46382461	162	328	26	81
ENST00000405308	1183	143	46382294	46382461	507	673	26	81
ENST00000407067	1043	143	46382294	46382461	383	549	26	81

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	26	81	Alternative sequence	ID=VSP_047452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17379400;Dbxref=PMID:17379400
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	29	31	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	38	43	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	57	63	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	66	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	76	79	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1MKN
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	21	143	Chain	ID=PRO_0000024662;Note=Midkine
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	37	61	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	45	70	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.
P21741	26	81	52	74	Disulfide bond	.

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3'-UTR located exon skipping events that lost miRNA binding sites in MDK

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for MDK

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MDK

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MDK

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for MDK

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for MDK

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MDK

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

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