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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ART3 |
 Gene summary |
| Gene information | Gene symbol | ART3 | Gene ID | 419 |
| Gene name | ADP-ribosyltransferase 3 | |
| Synonyms | ARTC3 | |
| Cytomap | 4q21.1|4p15.1-p14 | |
| Type of gene | protein-coding | |
| Description | ecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ART3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000156219
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ART3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104986 | chr4 | 76100291:76100320:76100795:76100824:76100990:76101019 | 76100795:76100824 |
| exon_skip_114261 | chr4 | 76075881:76075958:76081824:76082535:76097644:76097676 | 76081824:76082535 |
| exon_skip_118652 | chr4 | 76101004:76101019:76103937:76103969:76112386:76112412 | 76103937:76103969 |
| exon_skip_131318 | chr4 | 76075884:76075958:76097644:76097676:76098955:76098987 | 76097644:76097676 |
| exon_skip_162024 | chr4 | 76103937:76103969:76111907:76111994:76112386:76112412 | 76111907:76111994 |
| exon_skip_185895 | chr4 | 76104597:76104629:76107761:76107793:76112386:76112412 | 76107761:76107793 |
| exon_skip_195434 | chr4 | 76097644:76097676:76098955:76098987:76100291:76100320 | 76098955:76098987 |
| exon_skip_196885 | chr4 | 76104597:76104629:76105522:76105554:76107761:76107793 | 76105522:76105554 |
| exon_skip_205223 | chr4 | 76100795:76100824:76100990:76101019:76103937:76103969 | 76100990:76101019 |
| exon_skip_206025 | chr4 | 76075884:76075958:76081824:76082535:76097644:76097676 | 76081824:76082535 |
| exon_skip_206045 | chr4 | 76082499:76082535:76097644:76097676:76098955:76098987 | 76097644:76097676 |
| exon_skip_213040 | chr4 | 76103937:76103969:76104597:76104629:76107761:76107793 | 76104597:76104629 |
| exon_skip_215472 | chr4 | 76098955:76098987:76100291:76100320:76100795:76100824 | 76100291:76100320 |
| exon_skip_21696 | chr4 | 76104612:76104629:76107761:76107793:76112386:76112412 | 76107761:76107793 |
| exon_skip_237563 | chr4 | 76103937:76103969:76107761:76107793:76112386:76112412 | 76107761:76107793 |
| exon_skip_237983 | chr4 | 76103937:76103969:76111907:76111994:76112386:76112681 | 76111907:76111994 |
| exon_skip_262002 | chr4 | 76074713:76074819:76075881:76075958:76081824:76082076 | 76075881:76075958 |
| exon_skip_53118 | chr4 | 76075881:76075958:76100795:76100824:76100990:76101019 | 76100795:76100824 |
| exon_skip_65083 | chr4 | 76082499:76082535:76097644:76097676:76098955:76098985 | 76097644:76097676 |
| exon_skip_65445 | chr4 | 76100990:76101019:76103937:76103969:76112386:76112412 | 76103937:76103969 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_73027 | Mayo_CB | 4.808537e-01 | 6.276316e-01 | -1.467779e-01 | 1.632461e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for ART3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355810 | 76081824 | 76082535 | Frame-shift |
| ENST00000355810 | 76097644 | 76097676 | In-frame |
| ENST00000355810 | 76100291 | 76100320 | In-frame |
| ENST00000355810 | 76100795 | 76100824 | In-frame |
| ENST00000355810 | 76100990 | 76101019 | In-frame |
| ENST00000355810 | 76104597 | 76104629 | In-frame |
| ENST00000355810 | 76107761 | 76107793 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355810 | 76081824 | 76082535 | Frame-shift |
| ENST00000355810 | 76100795 | 76100824 | In-frame |
| ENST00000355810 | 76107761 | 76107793 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355810 | 76075881 | 76075958 | 5CDS-5UTR |
| ENST00000355810 | 76081824 | 76082535 | Frame-shift |
| ENST00000355810 | 76097644 | 76097676 | In-frame |
| ENST00000355810 | 76098955 | 76098987 | In-frame |
| ENST00000355810 | 76100291 | 76100320 | In-frame |
| ENST00000355810 | 76100795 | 76100824 | In-frame |
| ENST00000355810 | 76100990 | 76101019 | In-frame |
| ENST00000355810 | 76104597 | 76104629 | In-frame |
| ENST00000355810 | 76107761 | 76107793 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ART3 |
p-ENSG00000156219_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355810 | 1578 | 389 | 76097644 | 76097676 | 902 | 933 | 261 | 271 |
| ENST00000355810 | 1578 | 389 | 76100990 | 76101019 | 968 | 995 | 283 | 292 |
| ENST00000355810 | 1578 | 389 | 76100291 | 76100320 | 968 | 996 | 283 | 292 |
| ENST00000355810 | 1578 | 389 | 76100795 | 76100824 | 998 | 1026 | 293 | 302 |
| ENST00000355810 | 1578 | 389 | 76100990 | 76101019 | 1028 | 1056 | 303 | 312 |
| ENST00000355810 | 1578 | 389 | 76100291 | 76100320 | 1028 | 1055 | 303 | 312 |
| ENST00000355810 | 1578 | 389 | 76104597 | 76104629 | 1091 | 1122 | 324 | 334 |
| ENST00000355810 | 1578 | 389 | 76107761 | 76107793 | 1124 | 1155 | 335 | 345 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355810 | 1578 | 389 | 76100795 | 76100824 | 998 | 1026 | 293 | 302 |
| ENST00000355810 | 1578 | 389 | 76107761 | 76107793 | 1124 | 1155 | 335 | 345 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355810 | 1578 | 389 | 76097644 | 76097676 | 902 | 933 | 261 | 271 |
| ENST00000355810 | 1578 | 389 | 76098955 | 76098987 | 935 | 966 | 272 | 282 |
| ENST00000355810 | 1578 | 389 | 76100990 | 76101019 | 968 | 995 | 283 | 292 |
| ENST00000355810 | 1578 | 389 | 76100291 | 76100320 | 968 | 996 | 283 | 292 |
| ENST00000355810 | 1578 | 389 | 76100795 | 76100824 | 998 | 1026 | 293 | 302 |
| ENST00000355810 | 1578 | 389 | 76100990 | 76101019 | 1028 | 1056 | 303 | 312 |
| ENST00000355810 | 1578 | 389 | 76100291 | 76100320 | 1028 | 1055 | 303 | 312 |
| ENST00000355810 | 1578 | 389 | 76104597 | 76104629 | 1091 | 1122 | 324 | 334 |
| ENST00000355810 | 1578 | 389 | 76107761 | 76107793 | 1124 | 1155 | 335 | 345 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13508 | 261 | 271 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 283 | 292 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 283 | 292 | 283 | 292 | Repeat | Note=1 |
| Q13508 | 283 | 292 | 283 | 292 | Repeat | Note=1 |
| Q13508 | 293 | 302 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 293 | 302 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 293 | 302 | 293 | 302 | Repeat | Note=2 |
| Q13508 | 303 | 312 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 303 | 312 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 303 | 312 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 303 | 312 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 303 | 312 | 303 | 312 | Repeat | Note=3 |
| Q13508 | 303 | 312 | 303 | 312 | Repeat | Note=3 |
| Q13508 | 324 | 334 | 324 | 346 | Alternative sequence | ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984 |
| Q13508 | 324 | 334 | 324 | 334 | Alternative sequence | ID=VSP_003374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13508 | 324 | 334 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 335 | 345 | 324 | 346 | Alternative sequence | ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984 |
| Q13508 | 335 | 345 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13508 | 293 | 302 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 293 | 302 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 293 | 302 | 293 | 302 | Repeat | Note=2 |
| Q13508 | 335 | 345 | 324 | 346 | Alternative sequence | ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984 |
| Q13508 | 335 | 345 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13508 | 261 | 271 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 272 | 282 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 283 | 292 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 283 | 292 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 283 | 292 | 283 | 292 | Repeat | Note=1 |
| Q13508 | 283 | 292 | 283 | 292 | Repeat | Note=1 |
| Q13508 | 293 | 302 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 293 | 302 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 293 | 302 | 293 | 302 | Repeat | Note=2 |
| Q13508 | 303 | 312 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 303 | 312 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 303 | 312 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 303 | 312 | 283 | 312 | Region | Note=3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H |
| Q13508 | 303 | 312 | 303 | 312 | Repeat | Note=3 |
| Q13508 | 303 | 312 | 303 | 312 | Repeat | Note=3 |
| Q13508 | 324 | 334 | 324 | 346 | Alternative sequence | ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984 |
| Q13508 | 324 | 334 | 324 | 334 | Alternative sequence | ID=VSP_003374;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13508 | 324 | 334 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
| Q13508 | 335 | 345 | 324 | 346 | Alternative sequence | ID=VSP_003375;Note=In isoform 1. GMKIPEPFPLPEDKSQGNINNPT->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8605984;Dbxref=PMID:8605984 |
| Q13508 | 335 | 345 | 27 | 362 | Chain | ID=PRO_0000019325;Note=Ecto-ADP-ribosyltransferase 3 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ART3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ART3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ART3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ART3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ART3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_73027 | 5.151738e-01 | 4.337221e-12 |
| CB | TRA2A | exon_skip_73027 | -4.912628e-01 | 5.608321e-11 |
| CB | PTBP1 | exon_skip_73027 | -4.125567e-01 | 7.186120e-08 |
| CB | CNOT4 | exon_skip_81798 | -4.115334e-01 | 2.034187e-07 |
| CB | RBM3 | exon_skip_81798 | 5.652843e-01 | 7.161533e-14 |
| CB | PCBP4 | exon_skip_81798 | 4.811878e-01 | 5.994285e-10 |
| CB | TRA2A | exon_skip_81798 | -4.593279e-01 | 4.304017e-09 |
| CB | PABPC4 | exon_skip_81798 | 4.178142e-01 | 1.267128e-07 |
| CB | TRA2A | exon_skip_176562 | -4.858017e-01 | 8.532648e-11 |
| CB | PTBP1 | exon_skip_176562 | -4.008152e-01 | 1.646297e-07 |
| CB | CNOT4 | exon_skip_21291 | -4.002295e-01 | 1.722460e-07 |
| CB | RBM3 | exon_skip_21291 | 5.578312e-01 | 2.200195e-14 |
| CB | PCBP4 | exon_skip_21291 | 4.559219e-01 | 1.549883e-09 |
| CB | TRA2A | exon_skip_21291 | -4.580246e-01 | 1.275269e-09 |
| CB | RBM3 | exon_skip_185895 | 4.985119e-01 | 1.135269e-10 |
| TC | RBM24 | exon_skip_176562 | 5.501814e-01 | 5.823399e-14 |
| TC | RBM3 | exon_skip_21696 | 5.028710e-01 | 2.817133e-10 |
| TC | NOVA1 | exon_skip_21696 | 4.255297e-01 | 1.769765e-07 |
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RelatedDrugs for ART3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ART3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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