ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MBP

Gene summary

Gene information	Gene symbol	MBP
	Gene ID	4155
	Gene name	myelin basic protein
	Synonyms	-
	Cytomap	18q23
	Type of gene	protein-coding
	Description	myelin basic proteinGolli-MBPproline-rich proteoglycan 2myelin A1 proteinmyelin membrane encephalitogenic protein
	Modification date	20200313
	UniProtAcc	A0A024R384, A8MZH3, C9J6H1, E9PJ72, E9PKX9, E9PLQ9, E9PLU9, E9PMR5, E9PNZ1, E9PQE7, E9PSE2, F5H7N4, F8WEU6, H0YEA2, H0YF02, H7BYR8, J3KS94, J3KT01, J3KT34, J3QKL5, J3QKN5, J3QL64, J3QQK6, P02686, P13727,
	Context	- 24188129(The Absence of Myelin Basic Protein Promotes Neuroinflammation and Reduces Amyloid β-protein Accumulation in Tg-5xFAD Mice)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MBP	GO:0000165	MAPK cascade	22524708
MBP	GO:0034115	negative regulation of heterotypic cell-cell adhesion	22524708
MBP	GO:0035633	maintenance of permeability of blood-brain barrier	22524708
MBP	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	22524708
MBP	GO:1904685	positive regulation of metalloendopeptidase activity	22524708
MBP	GO:2000778	positive regulation of interleukin-6 secretion	22524708

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Gene structures and expression levels for MBP

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000197971

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
STG	UP	2.695656e+04	1.090689e+00	1.045522e-04	6.076583e-03
CB	DOWN	8.262632e+04	-1.211465e+00	4.238965e-10	1.587197e-08
TC	DOWN	4.006998e+05	-1.333301e+00	1.724649e-14	4.573024e-12

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
DLPFC	UP	ENST00000354542.4	MBP-201:protein_coding:MBP	1.598460e+01	9.903448e-01	7.154043e-08	3.897920e-05
PCC	UP	ENST00000354542.4	MBP-201:protein_coding:MBP	1.260780e+01	2.250320e+00	1.069301e-08	1.113019e-05
PCC	UP	ENST00000527041.1	MBP-228:protein_coding:MBP	2.318230e+01	1.113172e+00	1.272921e-07	6.166334e-05
PCC	UP	ENST00000359645.7	MBP-203:protein_coding:MBP	1.462798e+01	1.222302e+00	3.075194e-05	2.757788e-03
PCC	UP	ENST00000498683.2	MBP-226:protein_coding:MBP	2.941948e+00	1.093090e+00	2.612543e-03	4.604485e-02
STG	UP	ENST00000397865.9	MBP-207:protein_coding:MBP	4.994663e+03	1.753569e+00	1.394453e-07	1.068451e-04
STG	UP	ENST00000397868.6	MBP-209:retained_intron:MBP	5.978747e+01	8.639826e+00	1.907420e-06	8.230516e-04
STG	UP	ENST00000467108.1	MBP-214:retained_intron:MBP	8.601306e+01	1.128437e+00	4.341489e-06	1.561127e-03
STG	UP	ENST00000382582.7	MBP-204:protein_coding:MBP	1.601216e+03	2.013294e+00	1.151172e-05	2.969853e-03
STG	UP	ENST00000459948.1	MBP-213:nonsense_mediated_decay:MBP	4.169776e+01	1.140992e+00	5.356892e-05	7.721675e-03
STG	UP	ENST00000447114.5	MBP-212:protein_coding:MBP	3.254061e+01	8.837678e-01	1.338536e-04	1.313356e-02
STG	UP	ENST00000483025.5	MBP-217:nonsense_mediated_decay:MBP	3.293361e+01	1.429502e+00	1.997282e-04	1.645139e-02
STG	UP	ENST00000578715.5	MBP-235:lncRNA:MBP	4.737368e+01	9.754522e-01	2.063985e-04	1.681727e-02
STG	UP	ENST00000526111.5	MBP-227:protein_coding:MBP	1.133468e+02	1.519447e+00	2.185399e-04	1.732980e-02
STG	UP	ENST00000527975.5	MBP-229:nonsense_mediated_decay:MBP	1.027462e+02	1.164355e+00	7.160656e-04	3.220468e-02
PG	UP	ENST00000359645.7	MBP-203:protein_coding:MBP	6.218713e+01	2.655432e+01	1.162537e-44	5.737157e-40
PG	UP	ENST00000467108.1	MBP-214:retained_intron:MBP	1.237848e+02	8.358430e-01	2.340335e-06	1.700142e-04
PG	UP	ENST00000661150.1	DNMBP-AS1-203:lncRNA:DNMBP	1.921527e+00	1.559635e+00	3.813409e-04	7.291477e-03
PG	UP	ENST00000397865.9	MBP-207:protein_coding:MBP	1.040938e+04	8.944459e-01	4.476644e-04	8.168909e-03
PG	UP	ENST00000397863.5	MBP-206:protein_coding:MBP	5.975519e+02	1.133410e+00	1.644546e-03	2.079221e-02
CB	DOWN	ENST00000397866.8	MBP-208:protein_coding:MBP	4.751613e+04	-1.629897e+00	5.339535e-14	1.400331e-11
CB	DOWN	ENST00000527975.5	MBP-229:nonsense_mediated_decay:MBP	4.906210e+02	-1.459517e+00	3.757676e-11	2.821408e-09
CB	DOWN	ENST00000382582.7	MBP-204:protein_coding:MBP	5.336434e+03	-1.293186e+00	5.828539e-11	4.054962e-09
CB	DOWN	ENST00000397869.7	MBP-210:protein_coding:MBP	4.027619e+01	-1.568194e+00	2.075458e-10	1.170294e-08
CB	DOWN	ENST00000583474.5	MBP-245:nonsense_mediated_decay:MBP	2.561985e+02	-1.270385e+00	9.789084e-10	4.300521e-08
CB	UP	ENST00000495407.1	MCMBP-204:lncRNA:MCMBP	1.338210e+01	8.673210e-01	2.662103e-09	9.920505e-08
CB	DOWN	ENST00000483025.5	MBP-217:nonsense_mediated_decay:MBP	5.448152e+01	-1.113616e+00	5.843042e-08	1.347993e-06
CB	DOWN	ENST00000533278.5	MBP-232:nonsense_mediated_decay:MBP	2.787598e+01	-1.159005e+00	2.985810e-07	5.366638e-06
CB	DOWN	ENST00000487811.1	STAMBP-210:lncRNA:STAMBP	1.685190e+01	-8.262979e-01	6.084827e-07	9.826722e-06
CB	DOWN	ENST00000397868.6	MBP-209:retained_intron:MBP	7.132890e+02	-1.067320e+00	2.824319e-06	3.624844e-05
CB	DOWN	ENST00000526111.5	MBP-227:protein_coding:MBP	1.650575e+01	-1.124312e+00	6.467128e-06	7.285887e-05
CB	DOWN	ENST00000397865.9	MBP-207:protein_coding:MBP	2.649779e+04	-8.768259e-01	8.793377e-06	9.472725e-05
CB	DOWN	ENST00000582282.5	MBP-242:lncRNA:MBP	4.647863e+00	-1.566147e+00	7.911555e-05	6.081454e-04
CB	DOWN	ENST00000577755.5	MBP-233:nonsense_mediated_decay:MBP	7.593410e+00	-1.078384e+00	3.922884e-04	2.347911e-03
CB	DOWN	ENST00000473302.5	MBP-215:nonsense_mediated_decay:MBP	1.015203e+01	-1.116432e+00	5.869904e-04	3.300956e-03
CB	DOWN	ENST00000354542.4	MBP-201:protein_coding:MBP	1.947916e+01	-9.993497e-01	1.189353e-03	5.977044e-03
CB	DOWN	ENST00000579129.5	MBP-237:protein_coding:MBP	1.217673e+01	-8.136081e-01	1.647705e-03	7.844545e-03
CB	DOWN	ENST00000427093.5	DNMBP-AS1-201:lncRNA:DNMBP	1.977123e+00	-8.923044e-01	1.753372e-03	8.261116e-03
CB	DOWN	ENST00000394073.5	STAMBP-203:protein_coding:STAMBP	3.241319e+01	-3.160234e+00	3.834977e-03	1.579786e-02
CB	DOWN	ENST00000339566.7	STAMBP-201:protein_coding:STAMBP	8.589765e+01	-1.025439e+00	3.878925e-03	1.594654e-02
CB	DOWN	ENST00000397875.7	MBP-211:protein_coding:MBP	3.553721e+01	-1.453847e+00	7.422530e-03	2.722805e-02
TC	DOWN	ENST00000397866.8	MBP-208:protein_coding:MBP	2.170213e+05	-1.633099e+00	3.655003e-19	8.109155e-16
TC	DOWN	ENST00000397869.7	MBP-210:protein_coding:MBP	2.081107e+02	-1.622617e+00	1.169312e-15	1.086796e-12
TC	DOWN	ENST00000382582.7	MBP-204:protein_coding:MBP	2.306131e+04	-1.377604e+00	3.953420e-15	3.107524e-12
TC	DOWN	ENST00000527975.5	MBP-229:nonsense_mediated_decay:MBP	2.500925e+03	-1.439640e+00	4.655730e-15	3.538252e-12
TC	DOWN	ENST00000583474.5	MBP-245:nonsense_mediated_decay:MBP	1.228585e+03	-1.361178e+00	1.831250e-14	1.134682e-11
TC	DOWN	ENST00000483025.5	MBP-217:nonsense_mediated_decay:MBP	2.768261e+02	-1.236056e+00	5.110079e-13	2.055328e-10
TC	DOWN	ENST00000582282.5	MBP-242:lncRNA:MBP	2.206512e+01	-1.476585e+00	4.919857e-12	1.412851e-09
TC	DOWN	ENST00000526111.5	MBP-227:protein_coding:MBP	1.045912e+02	-1.255464e+00	6.143355e-11	1.280387e-08
TC	DOWN	ENST00000473302.5	MBP-215:nonsense_mediated_decay:MBP	5.148154e+01	-1.265922e+00	9.637134e-11	1.880348e-08
TC	DOWN	ENST00000577755.5	MBP-233:nonsense_mediated_decay:MBP	3.877385e+01	-1.342825e+00	1.332212e-10	2.506891e-08
TC	DOWN	ENST00000397868.6	MBP-209:retained_intron:MBP	4.323269e+03	-1.167689e+00	2.964870e-10	4.815061e-08
TC	DOWN	ENST00000459948.1	MBP-213:nonsense_mediated_decay:MBP	4.565851e+02	-1.101857e+00	1.065902e-09	1.396248e-07
TC	DOWN	ENST00000533278.5	MBP-232:nonsense_mediated_decay:MBP	1.371487e+02	-1.201258e+00	1.557910e-09	1.911685e-07
TC	DOWN	ENST00000579129.5	MBP-237:protein_coding:MBP	5.757348e+01	-1.050112e+00	2.417418e-09	2.721197e-07
TC	DOWN	ENST00000581179.5	MBP-240:lncRNA:MBP	2.728539e+02	-9.387211e-01	9.849683e-08	6.019027e-06
TC	DOWN	ENST00000397875.7	MBP-211:protein_coding:MBP	1.624407e+02	-1.213381e+00	3.666405e-07	1.790330e-05
TC	DOWN	ENST00000397865.9	MBP-207:protein_coding:MBP	1.228254e+05	-9.522641e-01	4.368784e-07	2.064038e-05
TC	DOWN	ENST00000528160.1	MBP-230:protein_coding:MBP	9.581984e+00	-1.343862e+00	6.926732e-07	2.994931e-05
TC	DOWN	ENST00000354542.4	MBP-201:protein_coding:MBP	9.831213e+01	-1.174954e+00	1.358226e-06	5.135574e-05
TC	DOWN	ENST00000580402.5	MBP-238:protein_coding:MBP	5.818450e+01	-1.612782e+00	2.035643e-05	4.538721e-04
TC	DOWN	ENST00000493623.5	MBP-223:nonsense_mediated_decay:MBP	4.606708e+00	-1.266939e+00	9.633864e-05	1.565315e-03
TC	DOWN	ENST00000578193.5	MBP-234:protein_coding:MBP	1.274807e+01	-1.456439e+00	1.896879e-04	2.682503e-03
TC	DOWN	ENST00000578873.5	MBP-236:protein_coding:MBP	1.628166e+00	-2.666613e+00	3.839091e-03	2.745179e-02
TC	DOWN	ENST00000580473.5	MBP-239:lncRNA:MBP	1.389730e+00	-1.035901e+00	4.194525e-03	2.934802e-02
TC	UP	ENST00000265132.8	AMBP-201:protein_coding:AMBP	1.416015e+00	8.936173e-01	4.304984e-03	2.993520e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MBP

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_101509	chr18	76989956:76990060:77009849:77009926:77016832:77016846	77009849:77009926
exon_skip_112484	chr18	76988495:76988527:76988877:76989076:76989956:76989990	76988877:76989076
exon_skip_133732	chr18	77017119:77017268:77066298:77066385:77105211:77105261	77066298:77066385
exon_skip_134788	chr18	76980427:76980471:76988877:76988912:76989956:76989990	76988877:76988912
exon_skip_136340	chr18	76984854:76984894:76988877:76988912:76989956:76989990	76988877:76988912
exon_skip_136503	chr18	76988495:76988527:76988877:76988912:76989956:76989990	76988877:76988912
exon_skip_136594	chr18	76985204:76985210:76986906:76986983:76988495:76988527	76986906:76986983
exon_skip_143890	chr18	76988495:76988527:76988877:76989053:76989956:76990060	76988877:76989053
exon_skip_156841	chr18	76980455:76980471:76984775:76984894:76988495:76988520	76984775:76984894
exon_skip_162989	chr18	76988511:76988527:76988877:76988942:76989956:76989990	76988877:76988942
exon_skip_164743	chr18	76984854:76984894:76988495:76988527:76988877:76988912	76988495:76988527
exon_skip_1823	chr18	76988495:76988527:76988877:76988942:76989956:76989990	76988877:76988942
exon_skip_19560	chr18	76989956:76990060:77016832:77017268:77066298:77066385	77016832:77017268
exon_skip_204324	chr18	76989956:76990060:77016832:77016846:77016914:77016931	77016832:77016846
exon_skip_204423	chr18	76988511:76988527:76988877:76988985:76989956:76990060	76988877:76988985
exon_skip_212455	chr18	76989956:76990060:77016832:77016846:77016914:77017065	77016832:77016846
exon_skip_240012	chr18	76988511:76988527:76988877:76989076:76989956:76989990	76988877:76989076
exon_skip_2413	chr18	77066312:77066385:77095368:77095550:77097251:77097474	77095368:77095550
exon_skip_246730	chr18	76980455:76980471:76982581:76982623:76984775:76984894	76982581:76982623
exon_skip_250100	chr18	76988495:76988527:76988877:76989076:76989956:76990060	76988877:76989076
exon_skip_264486	chr18	76980455:76980471:76984775:76984894:76985204:76985210	76984775:76984894
exon_skip_268399	chr18	77066312:77066385:77097251:77097474:77105211:77105261	77097251:77097474
exon_skip_281145	chr18	76980455:76980471:76984775:76984894:76988877:76988912	76984775:76984894
exon_skip_286035	chr18	76980427:76980471:76984775:76984894:76988877:76988912	76984775:76984894
exon_skip_38417	chr18	76984854:76984894:76985204:76985210:76988495:76988527	76985204:76985210
exon_skip_41530	chr18	76988511:76988527:76988877:76988912:76989956:76989990	76988877:76988912
exon_skip_51805	chr18	76990045:76990060:77016832:77016846:77016914:77017065	77016832:77016846
exon_skip_68013	chr18	76984854:76984894:76988300:76988527:76988877:76988912	76988300:76988527
exon_skip_86162	chr18	76988495:76988527:76988877:76989053:76989956:76989990	76988877:76989053
exon_skip_88213	chr18	76980455:76980471:76988877:76988912:76989956:76989990	76988877:76988912
exon_skip_88845	chr18	76988495:76988527:76988877:76988942:76989956:76990060	76988877:76988942
exon_skip_89096	chr18	76985250:76985431:76988495:76988527:76988877:76988912	76988495:76988527
exon_skip_89855	chr18	76988511:76988527:76988877:76989053:76989956:76990060	76988877:76989053
exon_skip_93497	chr18	76988495:76988527:76988877:76988985:76989956:76990060	76988877:76988985
exon_skip_94114	chr18	76990045:76990060:77016832:77017268:77066298:77066385	77016832:77017268
exon_skip_99438	chr18	76980455:76980471:76982581:76982623:76984775:76984808	76982581:76982623

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_164743	Mayo_CB	5.509756e-01	6.910390e-01	-1.400634e-01	3.068750e-09

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Open reading frame (ORF) annotation in the exon skipping event for MBP

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000355994	77016832	77017268	Frame-shift
ENST00000580402	77016832	77017268	Frame-shift
ENST00000355994	77066298	77066385	Frame-shift
ENST00000580402	77066298	77066385	Frame-shift
ENST00000355994	76984775	76984894	In-frame
ENST00000580402	76984775	76984894	In-frame
ENST00000355994	76988495	76988527	In-frame
ENST00000580402	76988495	76988527	In-frame
ENST00000355994	76988877	76988912	In-frame
ENST00000580402	76988877	76988912	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000355994	77016832	77017268	Frame-shift
ENST00000580402	77016832	77017268	Frame-shift
ENST00000355994	76984775	76984894	In-frame
ENST00000580402	76984775	76984894	In-frame
ENST00000355994	76988495	76988527	In-frame
ENST00000580402	76988495	76988527	In-frame
ENST00000355994	76988877	76988912	In-frame
ENST00000580402	76988877	76988912	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000355994	77016832	77017268	Frame-shift
ENST00000580402	77016832	77017268	Frame-shift
ENST00000355994	76984775	76984894	In-frame
ENST00000580402	76984775	76984894	In-frame
ENST00000355994	76988495	76988527	In-frame
ENST00000580402	76988495	76988527	In-frame
ENST00000355994	76988877	76988912	In-frame
ENST00000580402	76988877	76988912	In-frame

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Infer the effects of exon skipping event on protein functional features for MBP

p-ENSG00000197971_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355994	2789	304	76988877	76988912	946	980	227	238
ENST00000580402	932	304	76988877	76988912	682	716	227	238
ENST00000355994	2789	304	76988495	76988527	982	1013	239	249
ENST00000580402	932	304	76988495	76988527	718	749	239	249
ENST00000355994	2789	304	76984775	76984894	1015	1133	250	289
ENST00000580402	932	304	76984775	76984894	751	869	250	289

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355994	2789	304	76988877	76988912	946	980	227	238
ENST00000580402	932	304	76988877	76988912	682	716	227	238
ENST00000355994	2789	304	76988495	76988527	982	1013	239	249
ENST00000580402	932	304	76988495	76988527	718	749	239	249
ENST00000355994	2789	304	76984775	76984894	1015	1133	250	289
ENST00000580402	932	304	76984775	76984894	751	869	250	289

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355994	2789	304	76988877	76988912	946	980	227	238
ENST00000580402	932	304	76988877	76988912	682	716	227	238
ENST00000355994	2789	304	76988495	76988527	982	1013	239	249
ENST00000580402	932	304	76988495	76988527	718	749	239	249
ENST00000355994	2789	304	76984775	76984894	1015	1133	250	289
ENST00000580402	932	304	76984775	76984894	751	869	250	289

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	229	229	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02688
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	231	231	Modified residue	Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23828821;Dbxref=PMID:23828821
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	232	232	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P02687
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	227	238	237	237	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	241	241	Modified residue	Note=Symmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:5128665;Dbxref=PMID:5128665
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	249	249	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P25274
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	239	249	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	193	304	Alternative sequence	ID=VSP_003311;Note=In isoform 2. DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR->VSSEE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|Ref.11;Dbxref=P
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	240	250	Alternative sequence	ID=VSP_003310;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:2427738,ECO:0000303\|PubMed:2442403,ECO:0000303\|Ref.8;Dbxref=PMID:15489334,PMID:242
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	1	304	Chain	ID=PRO_0000158990;Note=Myelin basic protein
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	256	256	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:2466844;Dbxref=PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	264	264	Modified residue	Note=Citrulline%3B in form C8;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:23828821,ECO:0000269\|PubMed:2466844;Dbxref=PMID:23828821,PMID:2466844
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	281	281	Modified residue	Note=Deamidated glutamine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2
P02686	250	289	246	256	Region	Note=Induces experimental autoimmune encephalomyelitis (EAE) 2

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3'-UTR located exon skipping events that lost miRNA binding sites in MBP

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for MBP

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MBP

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	FL	exon_skip_164743	-3.042962e-01	1.240000e-05	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	MSBB	IFG	exon_skip_164743	-4.581386e-01	1.421808e-02	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	MSBB	STG	exon_skip_164743	-3.166522e-01	1.985654e-03	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	ROSMAP	DLPFC	exon_skip_164743	-3.071963e-01	6.260000e-09	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	ROSMAP	HCC	exon_skip_38417	3.898866e-01	2.410000e-11	chr18	-	76984854	76984894	76985204	76985210	76988495	76988527
ADstage	ROSMAP	HCC	exon_skip_164743	-3.329134e-01	1.730000e-08	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	ROSMAP	PCC	exon_skip_164743	-3.222338e-01	1.390000e-06	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912
ADstage	ROSMAP	PCC	exon_skip_38417	3.146064e-01	2.520000e-06	chr18	-	76984854	76984894	76985204	76985210	76988495	76988527
CDR	MSBB	IFG	exon_skip_164743	-4.652911e-01	1.259494e-02	chr18	-	76984854	76984894	76988495	76988527	76988877	76988912

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MBP

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_212455	rs470144	chr18:76989686	2.343354e-18	2.577960e-15
HCC	exon_skip_212455	rs509620	chr18:77005659	1.334602e-07	2.610506e-05
HCC	exon_skip_212455	rs470443	chr18:76992024	2.056407e-06	3.126133e-04
HCC	exon_skip_212455	rs11150993	chr18:77026569	1.103929e-04	9.943888e-03
HCC	exon_skip_212455	rs523243	chr18:77002629	1.789815e-04	1.483225e-02
HCC	exon_skip_212455	rs2282557	chr18:77013210	5.324743e-04	3.565545e-02
HCC	exon_skip_212455	rs595997	chr18:76999370	5.689973e-04	3.753333e-02
HCC	exon_skip_212455	rs470498	chr18:76999765	5.689973e-04	3.753333e-02
HCC	exon_skip_164743	rs470822	chr18:76981216	6.863932e-04	4.353936e-02
PCC	exon_skip_212455	rs470144	chr18:76989686	7.234950e-10	5.678853e-07
PCC	exon_skip_164743	rs17060086	chr18:76920230	5.122771e-05	1.010467e-02
PCC	exon_skip_212455	rs509620	chr18:77005659	1.265977e-04	2.072173e-02
PCC	exon_skip_164743	rs12962857	chr18:76929940	2.889877e-04	3.978708e-02
PCC	exon_skip_164743	rs17060109	chr18:76935263	2.889877e-04	3.978708e-02
PCC	exon_skip_164743	rs3911865	chr18:76956761	2.929686e-04	4.022163e-02
PCC	exon_skip_164743	rs8091823	chr18:76903469	3.796211e-04	4.906050e-02
DLPFC	exon_skip_51805	rs470144	chr18:76989686	2.404712e-04	1.797272e-02
DLPFC	exon_skip_164743	rs470822	chr18:76981216	4.704357e-04	3.075655e-02
DLPFC	exon_skip_164743	rs12962857	chr18:76929940	6.306208e-04	3.879955e-02
DLPFC	exon_skip_164743	rs17060109	chr18:76935263	6.306208e-04	3.879955e-02
DLPFC	exon_skip_164743	rs3911865	chr18:76956761	6.306208e-04	3.879955e-02
DLPFC	exon_skip_164743	rs11150993	chr18:77026569	6.767207e-04	4.107611e-02

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Correlation with RNA binding proteins (RBPs) for MBP

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	RBM6	exon_skip_164743	-4.231442e-01	2.747207e-08
CB	SAMD4A	exon_skip_164743	-5.861757e-01	4.762476e-16
CB	CNOT4	exon_skip_164743	-5.806434e-01	1.036187e-15
CB	FXR2	exon_skip_164743	-4.999411e-01	1.956688e-11
CB	HNRNPF	exon_skip_164743	-4.978403e-01	2.445717e-11
DLPFC	SAMD4A	exon_skip_164743	-4.197790e-01	4.495880e-16
FL	SRSF2	exon_skip_164743	4.528975e-01	1.862009e-11
FL	EIF4B	exon_skip_164743	4.150851e-01	1.088453e-09
HCC	SAMD4A	exon_skip_164743	-4.111916e-01	1.458454e-12
IFG	SRSF2	exon_skip_45288	4.406001e-01	1.894393e-02
IFG	HNRNPK	exon_skip_45288	4.001865e-01	3.484685e-02
IFG	NUP42	exon_skip_45288	5.272009e-01	3.942676e-03
IFG	PTBP3	exon_skip_45288	5.199793e-01	4.565401e-03
IFG	ILF2	exon_skip_212455	4.359855e-01	4.252299e-02
IFG	HNRNPH2	exon_skip_212455	5.313334e-01	1.093822e-02
PCC	SAMD4A	exon_skip_164743	-4.416088e-01	1.123147e-11
PG	SAMD4A	exon_skip_164743	-4.234272e-01	1.862616e-10

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RelatedDrugs for MBP

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P13727	approved\|investigational	DB00020	Sargramostim	biotech	P13727
P13727	approved\|withdrawn	DB06752	Chymopapain	biotech	P13727

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RelatedDiseases for MBP

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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