ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MAP2

Gene summary

Gene information	Gene symbol	MAP2
	Gene ID	4133
	Gene name	microtubule associated protein 2
	Synonyms	MAP-2\|MAP2A\|MAP2B\|MAP2C
	Cytomap	2q34
	Type of gene	protein-coding
	Description	microtubule-associated protein 2
	Modification date	20200313
	UniProtAcc	A0A024R3Y8, A0A024R3Z1, A0A024R409, A8MZ31, E7EV03, H7BZB9, P11137, Q6NYC5,
	Context	- 26071842(MAP2c Prevents Arachidonic Acid-Induced Fibril Formation of Tau: Role of Chaperone Activity and Phosphorylation)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

Gene structures and expression levels for MAP2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000078018

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000471619.5	MAP2-211:lncRNA:MAP2	3.301836e+01	9.382011e-01	1.010430e-03	3.862010e-02
PG	DOWN	ENST00000392193.5	MAP2-204:protein_coding:MAP2	4.270369e+01	-8.106967e-01	2.898299e-05	1.100529e-03
CB	UP	ENST00000445941.5	MAP2-206:protein_coding:MAP2	1.315134e+01	1.014282e+00	9.721179e-05	7.227352e-04
CB	UP	ENST00000447185.5	MAP2-207:protein_coding:MAP2	3.538722e+02	8.822813e-01	1.487128e-03	7.209055e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_106524	chr2	209680753:209680827:209692637:209696350:209696542:209696636	209692637:209696350
exon_skip_110583	chr2	209680753:209680827:209692637:209696350:209696542:209696572	209692637:209696350
exon_skip_114361	chr2	209680753:209680827:209692637:209696350:209696542:209696567	209692637:209696350
exon_skip_126581	chr2	209709954:209710254:209723595:209723687:209725709:209725757	209723595:209723687
exon_skip_160936	chr2	209680753:209680827:209690603:209690848:209692625:209692792	209690603:209690848
exon_skip_16338	chr2	209709954:209710254:209723595:209723687:209725709:209725790	209723595:209723687
exon_skip_167239	chr2	209680753:209680827:209692625:209696350:209696542:209696732	209692625:209696350
exon_skip_169206	chr2	209680750:209680827:209690603:209690848:209692625:209692726	209690603:209690848
exon_skip_173594	chr2	209696688:209696748:209696917:209697051:209700277:209700338	209696917:209697051
exon_skip_175196	chr2	209680753:209680827:209690603:209690848:209692625:209692655	209690603:209690848
exon_skip_175889	chr2	209680753:209680827:209692637:209696350:209696542:209696748	209692637:209696350
exon_skip_178531	chr2	209678572:209678685:209680750:209680827:209692625:209692792	209680750:209680827
exon_skip_183997	chr2	209680753:209680827:209692637:209696350:209696542:209696732	209692637:209696350
exon_skip_189293	chr2	209680753:209680827:209692637:209696350:209696542:209696556	209692637:209696350
exon_skip_194557	chr2	209507592:209507641:209580036:209580100:209625053:209625129	209580036:209580100
exon_skip_204410	chr2	209696314:209696350:209696542:209696748:209696917:209697051	209696542:209696748
exon_skip_245930	chr2	209700280:209700338:209704450:209704620:209705580:209705690	209704450:209704620
exon_skip_252200	chr2	209696542:209696748:209696917:209697051:209700277:209700338	209696917:209697051
exon_skip_256652	chr2	209700283:209700338:209703987:209704034:209704450:209704620	209703987:209704034
exon_skip_257025	chr2	209700280:209700338:209703987:209704034:209704450:209704620	209703987:209704034
exon_skip_266880	chr2	209709973:209710254:209723595:209723687:209725709:209725790	209723595:209723687
exon_skip_275924	chr2	209680753:209680827:209690603:209690848:209692625:209692657	209690603:209690848
exon_skip_277108	chr2	209710025:209710254:209723595:209723687:209725709:209725790	209723595:209723687
exon_skip_289874	chr2	209680753:209680827:209692625:209696350:209696542:209696636	209692625:209696350
exon_skip_32612	chr2	209696314:209696350:209696542:209696748:209700277:209700338	209696542:209696748
exon_skip_33757	chr2	209680753:209680827:209690603:209690848:209692625:209692726	209690603:209690848
exon_skip_34488	chr2	209680753:209680827:209692625:209696350:209696542:209696572	209692625:209696350
exon_skip_39893	chr2	209696669:209696748:209696917:209697051:209700277:209700338	209696917:209697051
exon_skip_44684	chr2	209696600:209696748:209696917:209697051:209700277:209700338	209696917:209697051
exon_skip_46284	chr2	209709954:209710254:209725709:209725790:209729850:209729868	209725709:209725790
exon_skip_47007	chr2	209710152:209710254:209723595:209723687:209725709:209725790	209723595:209723687
exon_skip_57031	chr2	209680753:209680827:209692625:209696350:209696542:209696748	209692625:209696350
exon_skip_75019	chr2	209700283:209700338:209704450:209704620:209705580:209705690	209704450:209704620
exon_skip_82099	chr2	209580041:209580100:209625053:209625129:209653142:209653432	209625053:209625129
exon_skip_93396	chr2	209680753:209680827:209692625:209696350:209696542:209696567	209692625:209696350
exon_skip_97697	chr2	209680753:209680827:209692625:209696350:209696542:209696556	209692625:209696350

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for MAP2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000360351	209625053	209625129	5UTR-5UTR
ENST00000360351	209725709	209725790	Frame-shift
ENST00000360351	209680750	209680827	In-frame
ENST00000360351	209692625	209696350	In-frame
ENST00000360351	209696542	209696748	In-frame
ENST00000360351	209696917	209697051	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000360351	209625053	209625129	5UTR-5UTR
ENST00000360351	209692625	209696350	In-frame
ENST00000360351	209696542	209696748	In-frame
ENST00000360351	209696917	209697051	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000360351	209625053	209625129	5UTR-5UTR
ENST00000360351	209725709	209725790	Frame-shift
ENST00000360351	209692625	209696350	In-frame
ENST00000360351	209696542	209696748	In-frame
ENST00000360351	209696917	209697051	In-frame

Top

Infer the effects of exon skipping event on protein functional features for MAP2

p-ENSG00000078018_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000360351	9728	1827	209680750	209680827	884	960	126	151
ENST00000360351	9728	1827	209692625	209696350	962	4686	152	1393
ENST00000360351	9728	1827	209696542	209696748	4688	4893	1394	1462
ENST00000360351	9728	1827	209696917	209697051	4895	5028	1463	1507

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000360351	9728	1827	209692625	209696350	962	4686	152	1393
ENST00000360351	9728	1827	209696542	209696748	4688	4893	1394	1462
ENST00000360351	9728	1827	209696917	209697051	4895	5028	1463	1507

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000360351	9728	1827	209692625	209696350	962	4686	152	1393
ENST00000360351	9728	1827	209696542	209696748	4688	4893	1394	1462
ENST00000360351	9728	1827	209696917	209697051	4895	5028	1463	1507

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P11137	126	151	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	126	151	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	126	151	140	140	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	126	151	143	143	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	152	1393	152	229	Alternative sequence	ID=VSP_043596;Note=In isoform 4. DLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHT->AAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNK;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;
P11137	152	1393	152	155	Alternative sequence	ID=VSP_011302;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8294038;Dbxref=PMID:8294038
P11137	152	1393	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	152	1393	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	152	1393	285	285	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	605	605	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	610	610	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	729	729	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	733	733	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	736	736	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	738	738	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	745	745	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	881	881	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	890	890	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	936	936	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1133	1133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1134	1134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1139	1139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1154	1154	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1155	1155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1159	1159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1347	1347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	1353	1353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	179	179	Natural variant	ID=VAR_050019;Note=E->G;Dbxref=dbSNP:rs6749066
P11137	152	1393	277	277	Natural variant	ID=VAR_036014;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
P11137	152	1393	423	423	Natural variant	ID=VAR_019613;Note=R->K;Dbxref=dbSNP:rs741006
P11137	152	1393	705	705	Natural variant	ID=VAR_036015;Note=In a colorectal cancer sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=dbSNP:rs146432517,PMID:16959974
P11137	152	1393	976	976	Natural variant	ID=VAR_050020;Note=H->L;Dbxref=dbSNP:rs13425372
P11137	152	1393	991	991	Natural variant	ID=VAR_050021;Note=G->R;Dbxref=dbSNP:rs35927101
P11137	152	1393	1099	1099	Natural variant	ID=VAR_050022;Note=M->V;Dbxref=dbSNP:rs17745550
P11137	152	1393	701	744	Region	Note=Interaction with KNDC1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	187	187	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	1394	1462	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1394	1462	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1394	1462	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1394	1462	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
P11137	1463	1507	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1463	1507	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1463	1507	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1463	1507	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P11137	152	1393	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	152	1393	152	229	Alternative sequence	ID=VSP_043596;Note=In isoform 4. DLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHT->AAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNK;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;
P11137	152	1393	152	155	Alternative sequence	ID=VSP_011302;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8294038;Dbxref=PMID:8294038
P11137	152	1393	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	152	1393	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	152	1393	285	285	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	605	605	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	610	610	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	729	729	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	733	733	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	736	736	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	738	738	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	745	745	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	881	881	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	890	890	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	936	936	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1133	1133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1134	1134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1139	1139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1154	1154	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1155	1155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1159	1159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1347	1347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	1353	1353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	179	179	Natural variant	ID=VAR_050019;Note=E->G;Dbxref=dbSNP:rs6749066
P11137	152	1393	277	277	Natural variant	ID=VAR_036014;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
P11137	152	1393	423	423	Natural variant	ID=VAR_019613;Note=R->K;Dbxref=dbSNP:rs741006
P11137	152	1393	705	705	Natural variant	ID=VAR_036015;Note=In a colorectal cancer sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=dbSNP:rs146432517,PMID:16959974
P11137	152	1393	976	976	Natural variant	ID=VAR_050020;Note=H->L;Dbxref=dbSNP:rs13425372
P11137	152	1393	991	991	Natural variant	ID=VAR_050021;Note=G->R;Dbxref=dbSNP:rs35927101
P11137	152	1393	1099	1099	Natural variant	ID=VAR_050022;Note=M->V;Dbxref=dbSNP:rs17745550
P11137	152	1393	701	744	Region	Note=Interaction with KNDC1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	187	187	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	1394	1462	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1394	1462	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1394	1462	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1394	1462	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
P11137	1463	1507	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1463	1507	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1463	1507	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1463	1507	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P11137	152	1393	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	152	1393	152	229	Alternative sequence	ID=VSP_043596;Note=In isoform 4. DLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHT->AAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNK;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;
P11137	152	1393	152	155	Alternative sequence	ID=VSP_011302;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8294038;Dbxref=PMID:8294038
P11137	152	1393	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	152	1393	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	152	1393	285	285	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	498	498	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	601	601	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	605	605	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	610	610	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	629	629	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	725	725	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	729	729	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	733	733	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	736	736	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	738	738	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	745	745	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	821	821	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	881	881	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	890	890	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	936	936	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1133	1133	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1134	1134	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1139	1139	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1154	1154	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P15146
P11137	152	1393	1155	1155	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1159	1159	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	1347	1347	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	1353	1353	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P11137	152	1393	179	179	Natural variant	ID=VAR_050019;Note=E->G;Dbxref=dbSNP:rs6749066
P11137	152	1393	277	277	Natural variant	ID=VAR_036014;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
P11137	152	1393	423	423	Natural variant	ID=VAR_019613;Note=R->K;Dbxref=dbSNP:rs741006
P11137	152	1393	705	705	Natural variant	ID=VAR_036015;Note=In a colorectal cancer sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=dbSNP:rs146432517,PMID:16959974
P11137	152	1393	976	976	Natural variant	ID=VAR_050020;Note=H->L;Dbxref=dbSNP:rs13425372
P11137	152	1393	991	991	Natural variant	ID=VAR_050021;Note=G->R;Dbxref=dbSNP:rs35927101
P11137	152	1393	1099	1099	Natural variant	ID=VAR_050022;Note=M->V;Dbxref=dbSNP:rs17745550
P11137	152	1393	701	744	Region	Note=Interaction with KNDC1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P20357
P11137	152	1393	187	187	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	152	1393	1112	1112	Sequence conflict	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P11137	1394	1462	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1394	1462	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1394	1462	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1394	1462	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255
P11137	1463	1507	152	1507	Alternative sequence	ID=VSP_003197;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:8294038;Dbxref=PMID:15489334,PMID:8294038
P11137	1463	1507	230	1528	Alternative sequence	ID=VSP_043597;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P11137	1463	1507	1	1827	Chain	ID=PRO_0000072747;Note=Microtubule-associated protein 2
P11137	1463	1507	1447	1467	Region	Note=Calmodulin-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255

Top

3'-UTR located exon skipping events that lost miRNA binding sites in MAP2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for MAP2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for MAP2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_167991

-5.466206e-01

2.615056e-03

chr2

209424058

209424276

209495518

209495629

209507592

209507641

CDR

MSBB

IFG

exon_skip_167991

-6.015636e-01

7.088610e-04

chr2

209424058

209424276

209495518

209495629

209507592

209507641

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for MAP2

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	ZNF326	exon_skip_93396	4.138526e-01	6.057540e-07
CB	ZNF326	exon_skip_114361	4.402645e-01	3.886021e-07
IFG	SFPQ	exon_skip_160936	-4.714245e-01	1.132883e-02
IFG	PCBP4	exon_skip_160936	-4.614472e-01	1.344690e-02
IFG	PABPC3	exon_skip_160936	-4.230590e-01	2.489249e-02
IFG	EWSR1	exon_skip_160936	-4.223697e-01	2.515416e-02
IFG	SRSF5	exon_skip_160936	-4.913790e-01	7.919992e-03
TC	PUM1	exon_skip_33757	4.100993e-01	5.340352e-07
TC	NUP42	exon_skip_33757	4.044166e-01	7.911479e-07

Top

RelatedDrugs for MAP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P11137	approved\|investigational	DB01196	Estramustine	small molecule	P11137
P11137	approved\|vet_approved	DB01229	Paclitaxel	small molecule	P11137
P11137	approved\|investigational	DB01248	Docetaxel	small molecule	P11137

Top

RelatedDiseases for MAP2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for MAP2

Gene structures and expression levels for MAP2

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2

Open reading frame (ORF) annotation in the exon skipping event for MAP2

Infer the effects of exon skipping event on protein functional features for MAP2

3'-UTR located exon skipping events that lost miRNA binding sites in MAP2

SNVs in the skipped exons for MAP2

AD stage-associated exon skippint events for MAP2

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2

Correlation with RNA binding proteins (RBPs) for MAP2

RelatedDrugs for MAP2

RelatedDiseases for MAP2