|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for MAP1B |
 Gene summary |
| Gene information | Gene symbol | MAP1B | Gene ID | 4131 |
| Gene name | microtubule associated protein 1B | |
| Synonyms | FUTSCH|MAP5|PPP1R102 | |
| Cytomap | 5q13.2 | |
| Type of gene | protein-coding | |
| Description | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 18079022(Amyloid-beta Peptide Binds to Microtubule-Associated Protein 1B (MAP1B)) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP1B | GO:0009987 | cellular process | 19567321 |
Top |
Gene structures and expression levels for MAP1B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000131711
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000511641.2 | MAP1B-204:protein_coding:MAP1B | 4.283365e+02 | -8.104127e-01 | 2.681052e-03 | 2.943948e-02 |
| CB | UP | ENST00000512974.5 | MAP1B-205:protein_coding:MAP1B | 3.622135e+01 | 1.027073e+00 | 1.948495e-09 | 7.572474e-08 |
| CB | UP | ENST00000511641.2 | MAP1B-204:protein_coding:MAP1B | 3.556125e+00 | 1.101951e+00 | 6.479231e-05 | 5.123377e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP1B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_152283 | chr5 | 72186614:72186754:72193278:72193328:72193866:72195314 | 72193278:72193328 |
| exon_skip_165411 | chr5 | 72183743:72183825:72186614:72186754:72193866:72195314 | 72186614:72186754 |
| exon_skip_194646 | chr5 | 72186614:72186754:72193278:72193328:72193866:72195110 | 72193278:72193328 |
| exon_skip_236153 | chr5 | 72197555:72200367:72203563:72203801:72205084:72209565 | 72203563:72203801 |
| exon_skip_282062 | chr5 | 72186614:72186754:72193278:72193328:72193866:72193965 | 72193278:72193328 |
| exon_skip_70179 | chr5 | 72199230:72200367:72203563:72203801:72205084:72209565 | 72203563:72203801 |
| exon_skip_74193 | chr5 | 72115698:72115799:72116422:72116453:72183743:72183825 | 72116422:72116453 |
| exon_skip_76641 | chr5 | 72193866:72200367:72203563:72203801:72205084:72209565 | 72203563:72203801 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MAP1B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296755 | 72203563 | 72203801 | Frame-shift |
| ENST00000296755 | 72186614 | 72186754 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296755 | 72203563 | 72203801 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296755 | 72203563 | 72203801 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for MAP1B |
p-ENSG00000131711_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296755 | 12053 | 2468 | 72186614 | 72186754 | 669 | 808 | 123 | 170 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P46821 | 123 | 170 | 2 | 2468 | Chain | ID=PRO_0000018604;Note=Microtubule-associated protein 1B |
| P46821 | 123 | 170 | 2 | 2206 | Chain | ID=PRO_0000418379;Note=MAP1B heavy chain |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in MAP1B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for MAP1B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for MAP1B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP1B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for MAP1B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for MAP1B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MAP1B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|