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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for LPP |
 Gene summary |
| Gene information | Gene symbol | LPP | Gene ID | 4026 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | - | |
| Cytomap | 3q27.3-q28 | |
| Type of gene | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LPP |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000145012
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000596605.2 | CLPP-205:protein_coding:CLPP | 8.169608e+01 | -8.771697e-01 | 1.368171e-06 | 1.957096e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LPP |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102247 | chr3 | 188484592:188484704:188524665:188524787:188609161:188609184 | 188524665:188524787 |
| exon_skip_131678 | chr3 | 188225405:188225527:188406112:188406313:188484592:188484595 | 188406112:188406313 |
| exon_skip_145979 | chr3 | 188212641:188212831:188225405:188225527:188406112:188406307 | 188225405:188225527 |
| exon_skip_157268 | chr3 | 188341663:188341719:188406112:188406313:188484592:188484595 | 188406112:188406313 |
| exon_skip_170261 | chr3 | 188225405:188225527:188341663:188341719:188406112:188406260 | 188341663:188341719 |
| exon_skip_177801 | chr3 | 188225405:188225527:188341663:188341719:188406112:188406157 | 188341663:188341719 |
| exon_skip_225312 | chr3 | 188208198:188208318:188341663:188341719:188406112:188406260 | 188341663:188341719 |
| exon_skip_279129 | chr3 | 188212704:188212831:188225405:188225527:188406112:188406260 | 188225405:188225527 |
| exon_skip_57724 | chr3 | 188341663:188341719:188406112:188406313:188484592:188484704 | 188406112:188406313 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LPP |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000617246 | 188406112 | 188406313 | 5CDS-5UTR |
| ENST00000640853 | 188406112 | 188406313 | 5CDS-5UTR |
| ENST00000617246 | 188341663 | 188341719 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000617246 | 188406112 | 188406313 | 5CDS-5UTR |
| ENST00000640853 | 188406112 | 188406313 | 5CDS-5UTR |
| ENST00000617246 | 188341663 | 188341719 | 5UTR-5UTR |
| ENST00000617246 | 188524665 | 188524787 | In-frame |
| ENST00000640853 | 188524665 | 188524787 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000640853 | 188406112 | 188406313 | 5CDS-5UTR |
| ENST00000617246 | 188341663 | 188341719 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for LPP |
p-ENSG00000145012_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000617246 | 18237 | 612 | 188524665 | 188524787 | 497 | 618 | 102 | 143 |
| ENST00000640853 | 18294 | 612 | 188524665 | 188524787 | 554 | 675 | 102 | 143 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q93052 | 102 | 143 | 1 | 612 | Chain | ID=PRO_0000075832;Note=Lipoma-preferred partner |
| Q93052 | 102 | 143 | 1 | 612 | Chain | ID=PRO_0000075832;Note=Lipoma-preferred partner |
| Q93052 | 102 | 143 | 41 | 370 | Compositional bias | Note=Pro-rich |
| Q93052 | 102 | 143 | 41 | 370 | Compositional bias | Note=Pro-rich |
| Q93052 | 102 | 143 | 108 | 108 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BFW7 |
| Q93052 | 102 | 143 | 108 | 108 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BFW7 |
| Q93052 | 102 | 143 | 116 | 116 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XI07 |
| Q93052 | 102 | 143 | 116 | 116 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XI07 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LPP |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for LPP |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LPP |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LPP |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LPP |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for LPP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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