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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANKRD36C |
 Gene summary |
| Gene information | Gene symbol | ANKRD36C | Gene ID | 400986 |
| Gene name | ankyrin repeat domain 36C | |
| Synonyms | - | |
| Cytomap | 2q11.1 | |
| Type of gene | protein-coding | |
| Description | ankyrin repeat domain-containing protein 36Cprotein immuno-reactive with anti-PTH polyclonal antibodies | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ANKRD36C |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000174501
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANKRD36C |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103107 | chr2 | 95919892:95919920:95921607:95921679:95921782:95921810 | 95921607:95921679 |
| exon_skip_105171 | chr2 | 95950749:95950779:95951348:95951408:95953939:95954005 | 95951348:95951408 |
| exon_skip_112433 | chr2 | 95935616:95935644:95938829:95938901:95938987:95939015 | 95938829:95938901 |
| exon_skip_120230 | chr2 | 95857479:95857492:95859861:95860074:95867440:95867581 | 95859861:95860074 |
| exon_skip_126456 | chr2 | 95956786:95956816:95958591:95958663:95958757:95958785 | 95958591:95958663 |
| exon_skip_134999 | chr2 | 95893696:95893724:95894213:95894275:95895399:95895430 | 95894213:95894275 |
| exon_skip_138217 | chr2 | 95889966:95889994:95891665:95891737:95891832:95891860 | 95891665:95891737 |
| exon_skip_139643 | chr2 | 95851694:95851787:95852126:95852196:95853709:95853861 | 95852126:95852196 |
| exon_skip_144774 | chr2 | 95856008:95856180:95857309:95857492:95859861:95859929 | 95857309:95857492 |
| exon_skip_144870 | chr2 | 95958757:95958785:95960473:95960545:95960639:95960667 | 95960473:95960545 |
| exon_skip_155934 | chr2 | 95893696:95893724:95894213:95894275:95895399:95895410 | 95894213:95894275 |
| exon_skip_178839 | chr2 | 95851694:95851787:95852126:95852196:95853709:95853718 | 95852126:95852196 |
| exon_skip_199420 | chr2 | 95891832:95891860:95899145:95899217:95899308:95899336 | 95899145:95899217 |
| exon_skip_218995 | chr2 | 95857479:95857492:95859861:95860074:95876439:95876509 | 95859861:95860074 |
| exon_skip_220957 | chr2 | 95904924:95904952:95905441:95905503:95906631:95906695 | 95905441:95905503 |
| exon_skip_222810 | chr2 | 95887925:95887997:95888092:95888120:95889799:95889871 | 95888092:95888120 |
| exon_skip_229085 | chr2 | 95895562:95895590:95902886:95902958:95903053:95903081 | 95902886:95902958 |
| exon_skip_234139 | chr2 | 95904924:95904952:95905441:95905503:95906631:95906703 | 95905441:95905503 |
| exon_skip_235532 | chr2 | 95836919:95837108:95851166:95851195:95851694:95851787 | 95851166:95851195 |
| exon_skip_244898 | chr2 | 95859923:95860074:95867440:95867581:95876439:95876509 | 95867440:95867581 |
| exon_skip_253615 | chr2 | 95893696:95893724:95894213:95894275:95895399:95895426 | 95894213:95894275 |
| exon_skip_267667 | chr2 | 95876439:95876509:95880427:95880499:95880595:95880623 | 95880427:95880499 |
| exon_skip_28675 | chr2 | 95938987:95939015:95941160:95941199:95944627:95944694 | 95941160:95941199 |
| exon_skip_294 | chr2 | 95978122:95978189:95980648:95980785:95982256:95982362 | 95980648:95980785 |
| exon_skip_45303 | chr2 | 95960639:95960667:95962352:95962424:95962519:95962547 | 95962352:95962424 |
| exon_skip_55972 | chr2 | 95941160:95941199:95944627:95944694:95945114:95945121 | 95944627:95944694 |
| exon_skip_56458 | chr2 | 95859861:95860074:95867440:95867581:95876439:95876509 | 95867440:95867581 |
| exon_skip_57528 | chr2 | 95893696:95893724:95894213:95894275:95895399:95895471 | 95894213:95894275 |
| exon_skip_71262 | chr2 | 95953939:95954005:95956786:95956816:95958591:95958663 | 95956786:95956816 |
| exon_skip_87005 | chr2 | 95927381:95927409:95929072:95929144:95929239:95929267 | 95929072:95929144 |
| exon_skip_97836 | chr2 | 95962519:95962547:95978122:95978189:95980648:95980785 | 95978122:95978189 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_57528 | MSBB_PG | 5.359864e-01 | 6.400000e-01 | -1.040136e-01 | 6.167902e-04 |
| exon_skip_57528 | Mayo_CB | 5.762667e-01 | 6.847368e-01 | -1.084702e-01 | 1.621652e-05 |
| exon_skip_112433 | Mayo_CB | 3.435135e-01 | 4.789831e-01 | -1.354695e-01 | 7.968688e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for ANKRD36C |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000456556 | 95852126 | 95852196 | Frame-shift |
| ENST00000456556 | 95857309 | 95857492 | Frame-shift |
| ENST00000456556 | 95859861 | 95860074 | Frame-shift |
| ENST00000456556 | 95867440 | 95867581 | Frame-shift |
| ENST00000456556 | 95880427 | 95880499 | Frame-shift |
| ENST00000456556 | 95891665 | 95891737 | Frame-shift |
| ENST00000456556 | 95938829 | 95938901 | Frame-shift |
| ENST00000456556 | 95956786 | 95956816 | Frame-shift |
| ENST00000456556 | 95978122 | 95978189 | Frame-shift |
| ENST00000456556 | 95980648 | 95980785 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000456556 | 95852126 | 95852196 | Frame-shift |
| ENST00000456556 | 95867440 | 95867581 | Frame-shift |
| ENST00000456556 | 95880427 | 95880499 | Frame-shift |
| ENST00000456556 | 95888092 | 95888120 | Frame-shift |
| ENST00000456556 | 95891665 | 95891737 | Frame-shift |
| ENST00000456556 | 95899145 | 95899217 | Frame-shift |
| ENST00000456556 | 95929072 | 95929144 | Frame-shift |
| ENST00000456556 | 95938829 | 95938901 | Frame-shift |
| ENST00000456556 | 95951348 | 95951408 | Frame-shift |
| ENST00000456556 | 95956786 | 95956816 | Frame-shift |
| ENST00000456556 | 95958591 | 95958663 | Frame-shift |
| ENST00000456556 | 95960473 | 95960545 | Frame-shift |
| ENST00000456556 | 95962352 | 95962424 | Frame-shift |
| ENST00000456556 | 95978122 | 95978189 | Frame-shift |
| ENST00000456556 | 95980648 | 95980785 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000456556 | 95852126 | 95852196 | Frame-shift |
| ENST00000456556 | 95867440 | 95867581 | Frame-shift |
| ENST00000456556 | 95891665 | 95891737 | Frame-shift |
| ENST00000456556 | 95938829 | 95938901 | Frame-shift |
| ENST00000456556 | 95941160 | 95941199 | Frame-shift |
| ENST00000456556 | 95944627 | 95944694 | Frame-shift |
| ENST00000456556 | 95951348 | 95951408 | Frame-shift |
| ENST00000456556 | 95956786 | 95956816 | Frame-shift |
| ENST00000456556 | 95958591 | 95958663 | Frame-shift |
| ENST00000456556 | 95978122 | 95978189 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ANKRD36C |
p-ENSG00000174501_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000456556 | 5445 | 1778 | 95980648 | 95980785 | 679 | 815 | 198 | 243 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000456556 | 5445 | 1778 | 95980648 | 95980785 | 679 | 815 | 198 | 243 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JPF3 | 198 | 243 | 1 | 973 | Alternative sequence | ID=VSP_033675;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005 |
| Q5JPF3 | 198 | 243 | 1 | 567 | Alternative sequence | ID=VSP_039672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5JPF3 | 198 | 243 | 1 | 1778 | Chain | ID=PRO_0000334545;Note=Ankyrin repeat domain-containing protein 36C |
| Q5JPF3 | 198 | 243 | 196 | 225 | Repeat | Note=ANK 5 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JPF3 | 198 | 243 | 1 | 973 | Alternative sequence | ID=VSP_033675;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005 |
| Q5JPF3 | 198 | 243 | 1 | 567 | Alternative sequence | ID=VSP_039672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5JPF3 | 198 | 243 | 1 | 1778 | Chain | ID=PRO_0000334545;Note=Ankyrin repeat domain-containing protein 36C |
| Q5JPF3 | 198 | 243 | 196 | 225 | Repeat | Note=ANK 5 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANKRD36C |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ANKRD36C |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANKRD36C |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANKRD36C |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANKRD36C |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM45 | exon_skip_139643 | 5.173325e-01 | 5.489192e-12 |
| FL | EIF4B | exon_skip_112433 | 4.811804e-01 | 8.066855e-12 |
| IFG | ENOX1 | exon_skip_47321 | 4.143750e-01 | 3.163923e-02 |
| IFG | CPEB2 | exon_skip_97836 | 4.267969e-01 | 2.967182e-02 |
| PG | EIF4B | exon_skip_112433 | 4.449585e-01 | 1.304397e-08 |
| PG | NOVA1 | exon_skip_112433 | 4.130780e-01 | 1.645143e-07 |
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RelatedDrugs for ANKRD36C |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD36C |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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