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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NBPF9 |
 Gene summary |
| Gene information | Gene symbol | NBPF9 | Gene ID | 400818 |
| Gene name | NBPF member 9 | |
| Synonyms | AE01 | |
| Cytomap | 1q21.2 | |
| Type of gene | protein-coding | |
| Description | neuroblastoma breakpoint family member 9 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NBPF9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000269713
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NBPF9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_113155 | chr1 | 149057335:149057507:149058164:149058215:149058925:149059097 | 149058164:149058215 |
| exon_skip_1686 | chr1 | 149077208:149077419:149077883:149077955:149079007:149079221 | 149077883:149077955 |
| exon_skip_200509 | chr1 | 149072718:149072932:149073768:149073870:149075655:149075864 | 149073768:149073870 |
| exon_skip_200764 | chr1 | 149090753:149090894:149092755:149092785:149098438:149098706 | 149092755:149092785 |
| exon_skip_224663 | chr1 | 149081965:149082174:149082277:149082430:149090753:149090894 | 149082277:149082430 |
| exon_skip_226939 | chr1 | 149079007:149079221:149080053:149080155:149081965:149082174 | 149080053:149080155 |
| exon_skip_24433 | chr1 | 149064431:149064482:149065637:149065689:149069594:149069645 | 149065637:149065689 |
| exon_skip_263115 | chr1 | 149080053:149080155:149081965:149082174:149090205:149090428 | 149081965:149082174 |
| exon_skip_263781 | chr1 | 149062093:149062265:149062862:149062913:149063633:149063805 | 149062862:149062913 |
| exon_skip_291935 | chr1 | 149079058:149079221:149080053:149080155:149081965:149082174 | 149080053:149080155 |
| exon_skip_47465 | chr1 | 149081965:149082174:149090205:149090428:149090753:149090894 | 149090205:149090428 |
| exon_skip_523 | chr1 | 149064431:149064482:149065526:149065689:149069594:149069645 | 149065526:149065689 |
| exon_skip_53289 | chr1 | 149073768:149073870:149075655:149075864:149077208:149077419 | 149075655:149075864 |
| exon_skip_78401 | chr1 | 149098438:149098706:149101262:149101379:149102729:149102847 | 149101262:149101379 |
| exon_skip_84621 | chr1 | 149077208:149077419:149077883:149077955:149079007:149079030 | 149077883:149077955 |
| exon_skip_89464 | chr1 | 149062093:149062265:149062862:149062913:149063633:149063799 | 149062862:149062913 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NBPF9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615421 | 149082277 | 149082430 | 3UTR-3UTR |
| ENST00000615421 | 149092755 | 149092785 | 3UTR-3UTR |
| ENST00000584027 | 149058164 | 149058215 | Frame-shift |
| ENST00000615421 | 149058164 | 149058215 | Frame-shift |
| ENST00000584027 | 149065526 | 149065689 | Frame-shift |
| ENST00000615421 | 149065526 | 149065689 | Frame-shift |
| ENST00000584027 | 149077883 | 149077955 | Frame-shift |
| ENST00000615421 | 149077883 | 149077955 | Frame-shift |
| ENST00000584027 | 149080053 | 149080155 | Frame-shift |
| ENST00000615421 | 149080053 | 149080155 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615421 | 149082277 | 149082430 | 3UTR-3UTR |
| ENST00000615421 | 149092755 | 149092785 | 3UTR-3UTR |
| ENST00000584027 | 149062862 | 149062913 | Frame-shift |
| ENST00000615421 | 149062862 | 149062913 | Frame-shift |
| ENST00000584027 | 149065526 | 149065689 | Frame-shift |
| ENST00000615421 | 149065526 | 149065689 | Frame-shift |
| ENST00000584027 | 149073768 | 149073870 | Frame-shift |
| ENST00000615421 | 149073768 | 149073870 | Frame-shift |
| ENST00000584027 | 149075655 | 149075864 | In-frame |
| ENST00000615421 | 149075655 | 149075864 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615421 | 149092755 | 149092785 | 3UTR-3UTR |
| ENST00000584027 | 149062862 | 149062913 | Frame-shift |
| ENST00000615421 | 149062862 | 149062913 | Frame-shift |
| ENST00000584027 | 149065526 | 149065689 | Frame-shift |
| ENST00000615421 | 149065526 | 149065689 | Frame-shift |
| ENST00000584027 | 149077883 | 149077955 | Frame-shift |
| ENST00000615421 | 149077883 | 149077955 | Frame-shift |
| ENST00000584027 | 149080053 | 149080155 | Frame-shift |
| ENST00000615421 | 149080053 | 149080155 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NBPF9 |
p-ENSG00000269713_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000584027 | 5051 | 1111 | 149075655 | 149075864 | 854 | 1062 | 259 | 329 |
| ENST00000584027 | 5051 | 1111 | 149075655 | 149075864 | 854 | 1062 | 259 | 329 |
| ENST00000615421 | 5852 | 1111 | 149075655 | 149075864 | 1649 | 1857 | 259 | 329 |
| ENST00000615421 | 5852 | 1111 | 149075655 | 149075864 | 1649 | 1857 | 259 | 329 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P0DPF3 | 259 | 329 | 1 | 1111 | Chain | ID=PRO_0000288044;Note=Neuroblastoma breakpoint family member 9 |
| P0DPF3 | 259 | 329 | 1 | 1111 | Chain | ID=PRO_0000288044;Note=Neuroblastoma breakpoint family member 9 |
| P0DPF3 | 259 | 329 | 1 | 1111 | Chain | ID=PRO_0000288044;Note=Neuroblastoma breakpoint family member 9 |
| P0DPF3 | 259 | 329 | 1 | 1111 | Chain | ID=PRO_0000288044;Note=Neuroblastoma breakpoint family member 9 |
| P0DPF3 | 259 | 329 | 165 | 259 | Domain | Note=NBPF 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00647 |
| P0DPF3 | 259 | 329 | 165 | 259 | Domain | Note=NBPF 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00647 |
| P0DPF3 | 259 | 329 | 165 | 259 | Domain | Note=NBPF 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00647 |
| P0DPF3 | 259 | 329 | 165 | 259 | Domain | Note=NBPF 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00647 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NBPF9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000615421 | 149092755 | 149092785 | hsa-miR-6809-5p | chr1:149092777-149092784 | 8mer-1a | chr1:149092766-149092785 | 155.00 | -12.01 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-34a-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-4682 | chr1:149082350-149082357 | 8mer-1a | chr1:149082331-149082359 | 152.00 | -25.39 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-34c-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-17-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-20a-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-1233-5p | chr1:149082297-149082304 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-6778-5p | chr1:149082297-149082304 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-526b-3p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-519d-3p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149092755 | 149092785 | hsa-miR-6809-5p | chr1:149092777-149092784 | 8mer-1a | chr1:149092766-149092785 | 155.00 | -12.01 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-449a | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-449b-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-219a-1-3p | chr1:149082348-149082355 | 8mer-1a | chr1:149082331-149082359 | 152.00 | -25.39 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-93-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-106b-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-361-5p | chr1:149082385-149082392 | 8mer-1a | chr1:149082371-149082392 | 152.00 | -17.81 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-20b-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| MSBB | ENST00000615421 | 149082277 | 149082430 | hsa-miR-106a-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-34a-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-4682 | chr1:149082350-149082357 | 8mer-1a | chr1:149082331-149082359 | 152.00 | -25.39 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-34c-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-17-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-20a-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-1233-5p | chr1:149082297-149082304 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-6778-5p | chr1:149082297-149082304 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-526b-3p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-519d-3p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149092755 | 149092785 | hsa-miR-6809-5p | chr1:149092777-149092784 | 8mer-1a | chr1:149092766-149092785 | 155.00 | -12.01 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-449a | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-449b-5p | chr1:149082366-149082373 | 8mer-1a | chr1:149082351-149082373 | 161.00 | -22.62 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-219a-1-3p | chr1:149082348-149082355 | 8mer-1a | chr1:149082331-149082359 | 152.00 | -25.39 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-93-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-106b-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-361-5p | chr1:149082385-149082392 | 8mer-1a | chr1:149082371-149082392 | 152.00 | -17.81 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-20b-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
| ROSMAP | ENST00000615421 | 149082277 | 149082430 | hsa-miR-106a-5p | chr1:149082305-149082312 | 8mer-1a | chr1:149082290-149082312 | 156.00 | -15.97 |
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SNVs in the skipped exons for NBPF9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NBPF9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NBPF9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NBPF9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NBPF9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBPF9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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