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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for LIFR |
 Gene summary |
| Gene information | Gene symbol | LIFR | Gene ID | 3977 |
| Gene name | LIF receptor subunit alpha | |
| Synonyms | CD118|LIF-R|SJS2|STWS|SWS | |
| Cytomap | 5p13.1 | |
| Type of gene | protein-coding | |
| Description | leukemia inhibitory factor receptorCD118 antigenLIF receptorLIF receptor alphaleukemia inhibitory factor receptor alpha | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LIFR | GO:0008284 | positive regulation of cell proliferation | 7957045|8999038 |
| LIFR | GO:0019221 | cytokine-mediated signaling pathway | 7957045 |
| LIFR | GO:0034097 | response to cytokine | 8999038 |
| LIFR | GO:0048861 | leukemia inhibitory factor signaling pathway | 8999038|12643274 |
| LIFR | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway | 12643274 |
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Gene structures and expression levels for LIFR |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000113594
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000511561.1 | LIFR-208:protein_coding:LIFR | 1.455888e+00 | 1.046669e+00 | 7.746924e-03 | 2.819758e-02 |
| CB | UP | ENST00000506990.5 | LIFR-205:protein_coding:LIFR | 7.251434e-01 | 1.010765e+00 | 1.260572e-02 | 4.196210e-02 |
| TC | UP | ENST00000511561.1 | LIFR-208:protein_coding:LIFR | 2.239543e+00 | 1.092281e+00 | 3.277966e-03 | 2.438549e-02 |
| TC | DOWN | ENST00000670079.1 | LIFR-AS1-211:lncRNA:LIFR | 2.996521e+01 | -1.036338e+00 | 4.458062e-03 | 3.074621e-02 |
| TC | UP | ENST00000506990.5 | LIFR-205:protein_coding:LIFR | 1.545686e+00 | 9.752992e-01 | 4.746850e-03 | 3.223845e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LIFR |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103025 | chr5 | 38474963:38482218:38482589:38482667:38484775:38484835 | 38482589:38482667 |
| exon_skip_122105 | chr5 | 38496382:38496595:38499513:38499583:38502637:38502675 | 38499513:38499583 |
| exon_skip_173027 | chr5 | 38474963:38482218:38482589:38482667:38484775:38484868 | 38482589:38482667 |
| exon_skip_190368 | chr5 | 38499513:38499583:38502637:38502799:38503976:38504043 | 38502637:38502799 |
| exon_skip_218632 | chr5 | 38530506:38530666:38555005:38555065:38556334:38556636 | 38555005:38555065 |
| exon_skip_226582 | chr5 | 38530554:38530666:38555005:38555065:38556334:38556636 | 38555005:38555065 |
| exon_skip_247100 | chr5 | 38499513:38499583:38502637:38502799:38503976:38504121 | 38502637:38502799 |
| exon_skip_254680 | chr5 | 38481299:38482218:38482589:38482667:38484775:38484868 | 38482589:38482667 |
| exon_skip_295263 | chr5 | 38530506:38530666:38555005:38555065:38556334:38556388 | 38555005:38555065 |
| exon_skip_37182 | chr5 | 38530572:38530666:38555005:38555065:38556334:38556636 | 38555005:38555065 |
| exon_skip_52607 | chr5 | 38484775:38484868:38485819:38485980:38489078:38489245 | 38485819:38485980 |
| exon_skip_79859 | chr5 | 38527175:38527294:38528726:38528840:38530506:38530666 | 38528726:38528840 |
| exon_skip_8567 | chr5 | 38490190:38490291:38493606:38493785:38496382:38496534 | 38493606:38493785 |
| exon_skip_91017 | chr5 | 38489078:38489245:38490190:38490291:38493606:38493785 | 38490190:38490291 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LIFR |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263409 | 38482589 | 38482667 | Frame-shift |
| ENST00000453190 | 38482589 | 38482667 | Frame-shift |
| ENST00000263409 | 38499513 | 38499583 | Frame-shift |
| ENST00000453190 | 38499513 | 38499583 | Frame-shift |
| ENST00000263409 | 38502637 | 38502799 | Frame-shift |
| ENST00000453190 | 38502637 | 38502799 | Frame-shift |
| ENST00000263409 | 38485819 | 38485980 | In-frame |
| ENST00000453190 | 38485819 | 38485980 | In-frame |
| ENST00000263409 | 38490190 | 38490291 | In-frame |
| ENST00000453190 | 38490190 | 38490291 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263409 | 38482589 | 38482667 | Frame-shift |
| ENST00000453190 | 38482589 | 38482667 | Frame-shift |
| ENST00000263409 | 38502637 | 38502799 | Frame-shift |
| ENST00000453190 | 38502637 | 38502799 | Frame-shift |
| ENST00000263409 | 38528726 | 38528840 | Frame-shift |
| ENST00000453190 | 38528726 | 38528840 | Frame-shift |
| ENST00000263409 | 38490190 | 38490291 | In-frame |
| ENST00000453190 | 38490190 | 38490291 | In-frame |
| ENST00000263409 | 38493606 | 38493785 | In-frame |
| ENST00000453190 | 38493606 | 38493785 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263409 | 38482589 | 38482667 | Frame-shift |
| ENST00000453190 | 38482589 | 38482667 | Frame-shift |
| ENST00000263409 | 38499513 | 38499583 | Frame-shift |
| ENST00000453190 | 38499513 | 38499583 | Frame-shift |
| ENST00000263409 | 38502637 | 38502799 | Frame-shift |
| ENST00000453190 | 38502637 | 38502799 | Frame-shift |
| ENST00000263409 | 38490190 | 38490291 | In-frame |
| ENST00000453190 | 38490190 | 38490291 | In-frame |
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Infer the effects of exon skipping event on protein functional features for LIFR |
p-ENSG00000113594_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263409 | 10106 | 1097 | 38490190 | 38490291 | 2229 | 2329 | 688 | 722 |
| ENST00000453190 | 4270 | 1097 | 38490190 | 38490291 | 2398 | 2498 | 688 | 722 |
| ENST00000263409 | 10106 | 1097 | 38485819 | 38485980 | 2499 | 2659 | 778 | 832 |
| ENST00000453190 | 4270 | 1097 | 38485819 | 38485980 | 2668 | 2828 | 778 | 832 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263409 | 10106 | 1097 | 38493606 | 38493785 | 2049 | 2227 | 628 | 688 |
| ENST00000453190 | 4270 | 1097 | 38493606 | 38493785 | 2218 | 2396 | 628 | 688 |
| ENST00000263409 | 10106 | 1097 | 38490190 | 38490291 | 2229 | 2329 | 688 | 722 |
| ENST00000453190 | 4270 | 1097 | 38490190 | 38490291 | 2398 | 2498 | 688 | 722 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263409 | 10106 | 1097 | 38490190 | 38490291 | 2229 | 2329 | 688 | 722 |
| ENST00000453190 | 4270 | 1097 | 38490190 | 38490291 | 2398 | 2498 | 688 | 722 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 778 | 832 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 778 | 832 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 778 | 832 | 724 | 833 | Domain | Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 778 | 832 | 724 | 833 | Domain | Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 778 | 832 | 787 | 787 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 778 | 832 | 787 | 787 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 778 | 832 | 785 | 785 | Natural variant | ID=VAR_029111;Note=V->I;Dbxref=dbSNP:rs3110234 |
| P42702 | 778 | 832 | 785 | 785 | Natural variant | ID=VAR_029111;Note=V->I;Dbxref=dbSNP:rs3110234 |
| P42702 | 778 | 832 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 778 | 832 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42702 | 628 | 688 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 628 | 688 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 628 | 688 | 538 | 629 | Domain | Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 628 | 688 | 538 | 629 | Domain | Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 628 | 688 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 628 | 688 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 628 | 688 | 652 | 652 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 652 | 652 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 663 | 663 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 663 | 663 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 680 | 680 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 680 | 680 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 633 | 633 | Natural variant | ID=VAR_021996;Note=I->M;Dbxref=dbSNP:rs2303743 |
| P42702 | 628 | 688 | 633 | 633 | Natural variant | ID=VAR_021996;Note=I->M;Dbxref=dbSNP:rs2303743 |
| P42702 | 628 | 688 | 664 | 664 | Natural variant | ID=VAR_038626;Note=S->L;Dbxref=dbSNP:rs3729744 |
| P42702 | 628 | 688 | 664 | 664 | Natural variant | ID=VAR_038626;Note=S->L;Dbxref=dbSNP:rs3729744 |
| P42702 | 628 | 688 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 628 | 688 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 45 | 1097 | Chain | ID=PRO_0000010902;Note=Leukemia inhibitory factor receptor |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 627 | 719 | Domain | Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P42702 | 688 | 722 | 45 | 833 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in LIFR |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for LIFR |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LIFR |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LIFR |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LIFR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for LIFR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIFR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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