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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ARHGDIB |
Gene summary |
Gene information | Gene symbol | ARHGDIB | Gene ID | 397 |
Gene name | Rho GDP dissociation inhibitor beta | |
Synonyms | D4|GDIA2|GDID4|LYGDI|Ly-GDI|RAP1GN1|RhoGDI2 | |
Cytomap | 12p12.3 | |
Type of gene | protein-coding | |
Description | rho GDP-dissociation inhibitor 2Rho GDI 2Rho GDP dissociation inhibitor (GDI) betarho-GDI beta | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ARHGDIB | GO:0035023 | regulation of Rho protein signal transduction | 7512369 |
ARHGDIB | GO:1901164 | negative regulation of trophoblast cell migration | 24554735 |
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Gene structures and expression levels for ARHGDIB |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | DOWN | ENST00000545895.5 | ARHGDIB-209:protein_coding:ARHGDIB | 1.054971e+00 | -1.217756e+00 | 6.259863e-03 | 3.959159e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ARHGDIB |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_263299 | chr12 | 14950532:14950724:14956176:14956333:14961537:14961591 | 14956176:14956333 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ARHGDIB |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000541546 | 14956176 | 14956333 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000541546 | 14956176 | 14956333 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ARHGDIB |
p-ENSG00000111348_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ARHGDIB |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-6730-3p | chr12:14956247-14956254 | 8mer-1a | chr12:14956234-14956254 | 151.00 | -18.63 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320b | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-9-3p | chr12:14956227-14956234 | 8mer-1a | chr12:14956213-14956234 | 140.00 | -9.79 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-3158-5p | chr12:14956216-14956223 | 8mer-1a | chr12:14956209-14956227 | 160.00 | -23.28 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320d | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-494-3p | chr12:14956260-14956267 | 8mer-1a | chr12:14956246-14956267 | 140.00 | -10.66 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-655-5p | chr12:14956306-14956313 | 8mer-1a | chr12:14956294-14956315 | 157.00 | -18.83 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4722-5p | chr12:14956291-14956298 | 8mer-1a | chr12:14956278-14956298 | 149.00 | -26.32 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4738-3p | chr12:14956322-14956329 | 8mer-1a | chr12:14956308-14956329 | 161.00 | -29.38 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320c | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-518a-5p | chr12:14956206-14956213 | 8mer-1a | chr12:14956201-14956222 | 170.00 | -25.41 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-527 | chr12:14956206-14956213 | 8mer-1a | chr12:14956201-14956222 | 170.00 | -25.41 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4429 | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-593-3p | chr12:14956220-14956227 | 8mer-1a | chr12:14956209-14956227 | 160.00 | -23.28 |
Mayo | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320a-3p | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-6730-3p | chr12:14956247-14956254 | 8mer-1a | chr12:14956234-14956254 | 151.00 | -18.63 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320b | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-9-3p | chr12:14956227-14956234 | 8mer-1a | chr12:14956213-14956234 | 140.00 | -9.79 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-3158-5p | chr12:14956216-14956223 | 8mer-1a | chr12:14956209-14956227 | 160.00 | -23.28 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320d | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-494-3p | chr12:14956260-14956267 | 8mer-1a | chr12:14956246-14956267 | 140.00 | -10.66 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-655-5p | chr12:14956306-14956313 | 8mer-1a | chr12:14956294-14956315 | 157.00 | -18.83 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4722-5p | chr12:14956291-14956298 | 8mer-1a | chr12:14956278-14956298 | 149.00 | -26.32 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4738-3p | chr12:14956322-14956329 | 8mer-1a | chr12:14956308-14956329 | 161.00 | -29.38 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320c | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-518a-5p | chr12:14956206-14956213 | 8mer-1a | chr12:14956201-14956222 | 170.00 | -25.41 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-527 | chr12:14956206-14956213 | 8mer-1a | chr12:14956201-14956222 | 170.00 | -25.41 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-4429 | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-593-3p | chr12:14956220-14956227 | 8mer-1a | chr12:14956209-14956227 | 160.00 | -23.28 |
ROSMAP | ENST00000541546 | 14956176 | 14956333 | hsa-miR-320a-3p | chr12:14956226-14956233 | 8mer-1a | chr12:14956212-14956233 | 152.00 | -19.73 |
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SNVs in the skipped exons for ARHGDIB |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ARHGDIB |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGDIB |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ARHGDIB |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ARHGDIB |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGDIB |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |