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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ARHGAP5 |
 Gene summary |
| Gene information | Gene symbol | ARHGAP5 | Gene ID | 394 |
| Gene name | Rho GTPase activating protein 5 | |
| Synonyms | GFI2|RhoGAP5|p190-B|p190BRhoGAP | |
| Cytomap | 14q12 | |
| Type of gene | protein-coding | |
| Description | rho GTPase-activating protein 5growth factor independent 2p100 RasGAP-associated p105 proteinp105 RhoGAPrho-type GTPase-activating protein 5 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ARHGAP5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100852
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000396582.6 | ARHGAP5-203:protein_coding:ARHGAP5 | 3.165670e+02 | 9.747077e-01 | 5.299167e-05 | 3.984878e-03 |
| HCC | UP | ENST00000396582.6 | ARHGAP5-203:protein_coding:ARHGAP5 | 1.481199e+02 | 1.000313e+00 | 7.813994e-09 | 5.662230e-06 |
| CB | UP | ENST00000555814.1 | ARHGAP5-208:protein_coding:ARHGAP5 | 8.094790e+00 | 9.547252e-01 | 3.541397e-06 | 4.389061e-05 |
| CB | UP | ENST00000556611.5 | ARHGAP5-210:protein_coding:ARHGAP5 | 7.195738e+02 | 9.172133e-01 | 4.597798e-05 | 3.831428e-04 |
| CB | UP | ENST00000539826.6 | ARHGAP5-206:protein_coding:ARHGAP5 | 1.195637e+02 | 5.598574e+00 | 5.697638e-04 | 3.218348e-03 |
| CB | UP | ENST00000557643.1 | ARHGAP5-211:nonsense_mediated_decay:ARHGAP5 | 2.984277e+01 | 8.094261e-01 | 1.331643e-03 | 6.571144e-03 |
| CB | UP | ENST00000433497.5 | ARHGAP5-205:protein_coding:ARHGAP5 | 9.482739e+02 | 9.415390e-01 | 3.793448e-03 | 1.565650e-02 |
| TC | UP | ENST00000433497.5 | ARHGAP5-205:protein_coding:ARHGAP5 | 9.607808e+02 | 8.836557e-01 | 4.498480e-04 | 5.292900e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ARHGAP5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101427 | chr14 | 32149902:32150033:32152423:32152528:32154621:32154633 | 32152423:32152528 |
| exon_skip_128454 | chr14 | 32077309:32077435:32090502:32094386:32117140:32117287 | 32090502:32094386 |
| exon_skip_13492 | chr14 | 32117143:32117287:32146263:32146340:32149902:32150033 | 32146263:32146340 |
| exon_skip_217983 | chr14 | 32094038:32094386:32117143:32117287:32146263:32146340 | 32117143:32117287 |
| exon_skip_222619 | chr14 | 32094038:32094386:32117140:32117287:32146263:32146340 | 32117140:32117287 |
| exon_skip_228811 | chr14 | 32076985:32077053:32090502:32094386:32117140:32117287 | 32090502:32094386 |
| exon_skip_242949 | chr14 | 32094370:32094386:32117140:32117287:32146263:32146340 | 32117140:32117287 |
| exon_skip_268794 | chr14 | 32094300:32094386:32117143:32117287:32146263:32146340 | 32117143:32117287 |
| exon_skip_272284 | chr14 | 32076985:32077053:32090502:32094386:32117143:32117287 | 32090502:32094386 |
| exon_skip_4044 | chr14 | 32077309:32077435:32117143:32117287:32146263:32146340 | 32117143:32117287 |
| exon_skip_63622 | chr14 | 32094370:32094386:32117143:32117287:32146263:32146340 | 32117143:32117287 |
| exon_skip_79296 | chr14 | 32094300:32094386:32117140:32117287:32146263:32146340 | 32117140:32117287 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ARHGAP5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000345122 | 32090502 | 32094386 | 5CDS-5UTR |
| ENST00000539826 | 32090502 | 32094386 | 5CDS-5UTR |
| ENST00000345122 | 32117140 | 32117287 | Frame-shift |
| ENST00000539826 | 32117140 | 32117287 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000345122 | 32090502 | 32094386 | 5CDS-5UTR |
| ENST00000345122 | 32117140 | 32117287 | Frame-shift |
| ENST00000539826 | 32117140 | 32117287 | Frame-shift |
| ENST00000345122 | 32146263 | 32146340 | In-frame |
| ENST00000539826 | 32146263 | 32146340 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000345122 | 32090502 | 32094386 | 5CDS-5UTR |
| ENST00000539826 | 32090502 | 32094386 | 5CDS-5UTR |
| ENST00000345122 | 32117140 | 32117287 | Frame-shift |
| ENST00000539826 | 32117140 | 32117287 | Frame-shift |
| ENST00000345122 | 32152423 | 32152528 | Frame-shift |
| ENST00000539826 | 32152423 | 32152528 | Frame-shift |
| ENST00000345122 | 32146263 | 32146340 | In-frame |
| ENST00000539826 | 32146263 | 32146340 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ARHGAP5 |
p-ENSG00000100852_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345122 | 9621 | 1502 | 32146263 | 32146340 | 4182 | 4258 | 1289 | 1314 |
| ENST00000539826 | 4898 | 1502 | 32146263 | 32146340 | 4104 | 4180 | 1289 | 1314 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345122 | 9621 | 1502 | 32146263 | 32146340 | 4182 | 4258 | 1289 | 1314 |
| ENST00000539826 | 4898 | 1502 | 32146263 | 32146340 | 4104 | 4180 | 1289 | 1314 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13017 | 1289 | 1314 | 1 | 1502 | Chain | ID=PRO_0000056702;Note=Rho GTPase-activating protein 5 |
| Q13017 | 1289 | 1314 | 1 | 1502 | Chain | ID=PRO_0000056702;Note=Rho GTPase-activating protein 5 |
| Q13017 | 1289 | 1314 | 1262 | 1449 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q13017 | 1289 | 1314 | 1262 | 1449 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q13017 | 1289 | 1314 | 1302 | 1314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1302 | 1314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1293 | 1297 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1293 | 1297 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13017 | 1289 | 1314 | 1 | 1502 | Chain | ID=PRO_0000056702;Note=Rho GTPase-activating protein 5 |
| Q13017 | 1289 | 1314 | 1 | 1502 | Chain | ID=PRO_0000056702;Note=Rho GTPase-activating protein 5 |
| Q13017 | 1289 | 1314 | 1262 | 1449 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q13017 | 1289 | 1314 | 1262 | 1449 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q13017 | 1289 | 1314 | 1302 | 1314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1302 | 1314 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1293 | 1297 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
| Q13017 | 1289 | 1314 | 1293 | 1297 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EE4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ARHGAP5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ARHGAP5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ARHGAP5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ARHGAP5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_31501 | -4.095199e-01 | 2.362690e-07 |
| CB | HNRNPA1 | exon_skip_31501 | 4.224002e-01 | 8.913636e-08 |
| TC | RBM3 | exon_skip_128454 | 4.567050e-01 | 1.278527e-09 |
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RelatedDrugs for ARHGAP5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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