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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIF5B |
 Gene summary |
| Gene information | Gene symbol | KIF5B | Gene ID | 3799 |
| Gene name | kinesin family member 5B | |
| Synonyms | HEL-S-61|KINH|KNS|KNS1|UKHC | |
| Cytomap | 10p11.22 | |
| Type of gene | protein-coding | |
| Description | kinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chain | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KIF5B | GO:0042391 | regulation of membrane potential | 19675065 |
| KIF5B | GO:0043268 | positive regulation of potassium ion transport | 19675065 |
| KIF5B | GO:0047496 | vesicle transport along microtubule | 28426968 |
| KIF5B | GO:1903078 | positive regulation of protein localization to plasma membrane | 19675065 |
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Gene structures and expression levels for KIF5B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000170759
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIF5B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106515 | chr10 | 32017207:32017359:32018052:32018156:32018316:32018387 | 32018052:32018156 |
| exon_skip_12961 | chr10 | 32037520:32037607:32038163:32038218:32038778:32038826 | 32038163:32038218 |
| exon_skip_134639 | chr10 | 32022848:32023036:32028428:32028571:32031073:32031279 | 32028428:32028571 |
| exon_skip_188825 | chr10 | 32009015:32011516:32015509:32015659:32017143:32017359 | 32015509:32015659 |
| exon_skip_193610 | chr10 | 32018316:32018387:32018502:32018562:32019858:32019959 | 32018502:32018562 |
| exon_skip_258430 | chr10 | 32038778:32038826:32039327:32039431:32040384:32040457 | 32039327:32039431 |
| exon_skip_65913 | chr10 | 32018052:32018156:32018316:32018387:32018502:32018562 | 32018316:32018387 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KIF5B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000302418 | 32015509 | 32015659 | 5CDS-5UTR |
| ENST00000302418 | 32038163 | 32038218 | Frame-shift |
| ENST00000302418 | 32018316 | 32018387 | In-frame |
| ENST00000302418 | 32028428 | 32028571 | In-frame |
| ENST00000302418 | 32039327 | 32039431 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000302418 | 32015509 | 32015659 | 5CDS-5UTR |
| ENST00000302418 | 32028428 | 32028571 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000302418 | 32018502 | 32018562 | Frame-shift |
| ENST00000302418 | 32038163 | 32038218 | Frame-shift |
| ENST00000302418 | 32018052 | 32018156 | In-frame |
| ENST00000302418 | 32018316 | 32018387 | In-frame |
| ENST00000302418 | 32028428 | 32028571 | In-frame |
| ENST00000302418 | 32039327 | 32039431 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIF5B |
p-ENSG00000170759_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000302418 | 5894 | 963 | 32039327 | 32039431 | 747 | 850 | 96 | 130 |
| ENST00000302418 | 5894 | 963 | 32028428 | 32028571 | 2040 | 2182 | 527 | 574 |
| ENST00000302418 | 5894 | 963 | 32018316 | 32018387 | 2826 | 2896 | 789 | 812 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000302418 | 5894 | 963 | 32028428 | 32028571 | 2040 | 2182 | 527 | 574 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000302418 | 5894 | 963 | 32039327 | 32039431 | 747 | 850 | 96 | 130 |
| ENST00000302418 | 5894 | 963 | 32028428 | 32028571 | 2040 | 2182 | 527 | 574 |
| ENST00000302418 | 5894 | 963 | 32018316 | 32018387 | 2826 | 2896 | 789 | 812 |
| ENST00000302418 | 5894 | 963 | 32018052 | 32018156 | 2898 | 3001 | 813 | 847 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P33176 | 96 | 130 | 124 | 138 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 96 | 130 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 96 | 130 | 8 | 325 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| P33176 | 96 | 130 | 107 | 122 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 96 | 130 | 102 | 104 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 527 | 574 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 527 | 574 | 329 | 914 | Coiled coil | . |
| P33176 | 789 | 812 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 789 | 812 | 329 | 914 | Coiled coil | . |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P33176 | 527 | 574 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 527 | 574 | 329 | 914 | Coiled coil | . |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P33176 | 96 | 130 | 124 | 138 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 96 | 130 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 96 | 130 | 8 | 325 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| P33176 | 96 | 130 | 107 | 122 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 96 | 130 | 102 | 104 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BG2 |
| P33176 | 527 | 574 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 527 | 574 | 329 | 914 | Coiled coil | . |
| P33176 | 789 | 812 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 789 | 812 | 329 | 914 | Coiled coil | . |
| P33176 | 813 | 847 | 2 | 963 | Chain | ID=PRO_0000125351;Note=Kinesin-1 heavy chain |
| P33176 | 813 | 847 | 329 | 914 | Coiled coil | . |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIF5B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIF5B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIF5B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF5B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KIF5B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for KIF5B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF5B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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