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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIF2A |
 Gene summary |
| Gene information | Gene symbol | KIF2A | Gene ID | 3796 |
| Gene name | kinesin family member 2A | |
| Synonyms | CDCBM3|HK2|KIF2 | |
| Cytomap | 5q12.1 | |
| Type of gene | protein-coding | |
| Description | kinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2 | |
| Modification date | 20200318 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KIF2A | GO:0007052 | mitotic spindle organization | 18411309 |
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Gene structures and expression levels for KIF2A |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000068796
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000509624.1 | KIF2A-206:retained_intron:KIF2A | 1.057035e+00 | 8.033160e-01 | 7.138898e-03 | 2.636741e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIF2A |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_132385 | chr5 | 62377732:62377762:62381118:62381253:62385484:62385628 | 62381118:62381253 |
| exon_skip_163118 | chr5 | 62306251:62306536:62308309:62308511:62347130:62347224 | 62308309:62308511 |
| exon_skip_178417 | chr5 | 62365243:62365353:62366414:62366481:62373687:62373837 | 62366414:62366481 |
| exon_skip_203877 | chr5 | 62357691:62357745:62358137:62358299:62361242:62361279 | 62358137:62358299 |
| exon_skip_210151 | chr5 | 62306458:62306536:62347130:62347224:62348048:62348167 | 62347130:62347224 |
| exon_skip_22672 | chr5 | 62306458:62306536:62308309:62308511:62347130:62347224 | 62308309:62308511 |
| exon_skip_228479 | chr5 | 62377661:62377762:62381118:62381253:62385484:62385628 | 62381118:62381253 |
| exon_skip_248678 | chr5 | 62366414:62366481:62372438:62372551:62373687:62373837 | 62372438:62372551 |
| exon_skip_43665 | chr5 | 62373687:62373837:62377661:62377762:62381118:62381253 | 62377661:62377762 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_248678 | ROSMAP_DLPFC | 2.434184e-01 | 3.463107e-01 | -1.028923e-01 | 1.129117e-03 |
| exon_skip_248678 | ROSMAP_PCC | 2.866667e-01 | 3.930588e-01 | -1.063922e-01 | 1.732406e-04 |
| exon_skip_248678 | MSBB_STG | 3.681818e-01 | 4.900000e-01 | -1.218182e-01 | 3.505990e-02 |
| exon_skip_248678 | MSBB_PG | 2.802055e-01 | 4.561404e-01 | -1.759349e-01 | 1.235172e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for KIF2A |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for KIF2A |
p-ENSG00000068796_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIF2A |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIF2A |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIF2A |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF2A |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| TC | exon_skip_248678 | rs37032 | chr5:62388203 | 3.223357e-05 | 6.528330e-03 |
| TC | exon_skip_248678 | rs4700005 | chr5:62297450 | 3.984910e-04 | 4.910644e-02 |
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Correlation with RNA binding proteins (RBPs) for KIF2A |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | ELAVL4 | exon_skip_248678 | 4.582052e-01 | 3.724623e-09 |
| CB | UNK | exon_skip_248678 | 5.235279e-01 | 6.244219e-12 |
| CB | PCBP2 | exon_skip_248678 | 5.132638e-01 | 1.868071e-11 |
| CB | HNRNPA0 | exon_skip_248678 | 5.809528e-01 | 6.514483e-15 |
| CB | PUF60 | exon_skip_248678 | 4.105627e-01 | 1.806515e-07 |
| CB | NUP42 | exon_skip_248678 | 6.048451e-01 | 2.468218e-16 |
| CB | PTBP3 | exon_skip_248678 | 4.930013e-01 | 1.464171e-10 |
| CB | SRSF9 | exon_skip_248678 | 5.805020e-01 | 6.911879e-15 |
| CB | EIF4B | exon_skip_248678 | 5.249164e-01 | 5.368689e-12 |
| DLPFC | ELAVL4 | exon_skip_248678 | 5.409226e-01 | 4.019090e-24 |
| DLPFC | ENOX1 | exon_skip_248678 | 4.348019e-01 | 3.208392e-15 |
| DLPFC | HNRNPA0 | exon_skip_248678 | 4.104399e-01 | 1.404841e-13 |
| DLPFC | PTBP3 | exon_skip_248678 | 4.256542e-01 | 1.374582e-14 |
| DLPFC | EIF4B | exon_skip_248678 | 5.564827e-01 | 1.038028e-25 |
| FL | ELAVL4 | exon_skip_248678 | 7.067347e-01 | 5.628855e-31 |
| FL | ILF2 | exon_skip_248678 | 5.720910e-01 | 1.972418e-18 |
| FL | HNRNPA0 | exon_skip_248678 | 5.507568e-01 | 6.095600e-17 |
| FL | PUF60 | exon_skip_248678 | 4.379377e-01 | 1.371077e-10 |
| FL | PTBP1 | exon_skip_248678 | -5.068280e-01 | 3.462974e-14 |
| FL | SRSF9 | exon_skip_248678 | 5.220596e-01 | 4.257514e-15 |
| FL | EIF4B | exon_skip_248678 | 5.167932e-01 | 8.892831e-15 |
| HCC | RBM5 | exon_skip_248678 | -6.172124e-01 | 4.685995e-30 |
| HCC | PCBP4 | exon_skip_248678 | -4.964153e-01 | 2.162060e-18 |
| HCC | UNK | exon_skip_248678 | -5.698227e-01 | 6.653587e-25 |
| HCC | PCBP2 | exon_skip_248678 | -4.173789e-01 | 6.215276e-13 |
| HCC | PTBP1 | exon_skip_248678 | -7.448904e-01 | 1.523247e-49 |
| IFG | ELAVL4 | exon_skip_248678 | 5.248301e-01 | 4.138576e-03 |
| IFG | PCBP4 | exon_skip_248678 | -4.274361e-01 | 2.328209e-02 |
| IFG | PTBP1 | exon_skip_248678 | -5.095363e-01 | 5.612880e-03 |
| PCC | ELAVL4 | exon_skip_248678 | 6.059009e-01 | 7.812448e-23 |
| PCC | PCBP4 | exon_skip_248678 | -4.626135e-01 | 9.550189e-13 |
| PCC | PTBP1 | exon_skip_248678 | -7.004056e-01 | 6.949737e-33 |
| PG | ELAVL4 | exon_skip_248678 | 7.381646e-01 | 3.317910e-36 |
| PG | ILF2 | exon_skip_248678 | 5.347167e-01 | 2.079347e-16 |
| PG | HNRNPA0 | exon_skip_248678 | 5.041573e-01 | 1.742629e-14 |
| PG | PUF60 | exon_skip_248678 | 4.712351e-01 | 1.286202e-12 |
| PG | PTBP1 | exon_skip_248678 | -4.663642e-01 | 2.339446e-12 |
| PG | EIF4B | exon_skip_248678 | 4.418470e-01 | 4.132331e-11 |
| STG | ELAVL4 | exon_skip_248678 | 6.841564e-01 | 1.060679e-13 |
| STG | ILF2 | exon_skip_248678 | 5.389065e-01 | 4.264917e-08 |
| STG | HNRNPA0 | exon_skip_248678 | 5.837972e-01 | 1.547092e-09 |
| STG | NUP42 | exon_skip_248678 | 4.580886e-01 | 5.626600e-06 |
| STG | PTBP1 | exon_skip_248678 | -5.010128e-01 | 4.921286e-07 |
| STG | PTBP3 | exon_skip_248678 | 4.283991e-01 | 2.527798e-05 |
| STG | SRSF9 | exon_skip_248678 | 4.649143e-01 | 3.903150e-06 |
| STG | EIF4B | exon_skip_248678 | 4.493732e-01 | 8.874604e-06 |
| TC | ELAVL4 | exon_skip_248678 | 8.238172e-01 | 8.579533e-41 |
| TC | ILF2 | exon_skip_248678 | 5.417928e-01 | 1.379530e-13 |
| TC | ENOX1 | exon_skip_248678 | 4.180007e-01 | 3.802443e-08 |
| TC | HNRNPA0 | exon_skip_248678 | 7.183075e-01 | 1.117699e-26 |
| TC | NUP42 | exon_skip_248678 | 6.890432e-01 | 7.373028e-24 |
| TC | PTBP1 | exon_skip_248678 | -4.196432e-01 | 3.320623e-08 |
| TC | PTBP3 | exon_skip_248678 | 5.082111e-01 | 6.877497e-12 |
| TC | SRSF9 | exon_skip_248678 | 4.239147e-01 | 2.326569e-08 |
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RelatedDrugs for KIF2A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF2A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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