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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KDR |
 Gene summary |
| Gene information | Gene symbol | KDR | Gene ID | 3791 |
| Gene name | kinase insert domain receptor | |
| Synonyms | CD309|FLK1|VEGFR|VEGFR2 | |
| Cytomap | 4q12 | |
| Type of gene | protein-coding | |
| Description | vascular endothelial growth factor receptor 2fetal liver kinase-1kinase insert domain receptor (a type III receptor tyrosine kinase)protein-tyrosine kinase receptor Flk-1soluble VEGFR2tyrosine kinase growth factor receptor | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KDR | GO:0001934 | positive regulation of protein phosphorylation | 19033661 |
| KDR | GO:0008284 | positive regulation of cell proliferation | 7929439 |
| KDR | GO:0008360 | regulation of cell shape | 7929439 |
| KDR | GO:0010629 | negative regulation of gene expression | 26879375 |
| KDR | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 9804796 |
| KDR | GO:0018108 | peptidyl-tyrosine phosphorylation | 10037737|10102632 |
| KDR | GO:0030335 | positive regulation of cell migration | 7929439 |
| KDR | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 10102632|11387210|19033661|23529610 |
| KDR | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway | 21885851 |
| KDR | GO:0043410 | positive regulation of MAPK cascade | 11387210 |
| KDR | GO:0046777 | protein autophosphorylation | 10037737|10102632|19033661 |
| KDR | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 10102632|11387210|15215251 |
| KDR | GO:0050927 | positive regulation of positive chemotaxis | 7929439 |
| KDR | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 10600473 |
| KDR | GO:0051894 | positive regulation of focal adhesion assembly | 12820653 |
| KDR | GO:1904881 | cellular response to hydrogen sulfide | 26879375 |
| KDR | GO:2000352 | negative regulation of endothelial cell apoptotic process | 9804796 |
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Gene structures and expression levels for KDR |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000128052
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000647068.1 | KDR-204:lncRNA:KDR | 4.646527e+01 | 1.282444e+00 | 8.957712e-05 | 2.527642e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KDR |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_246669 | chr4 | 55118604:55118800:55121097:55121190:55125227:55125293 | 55121097:55121190 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KDR |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for KDR |
p-ENSG00000128052_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in KDR |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KDR |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KDR |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KDR |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KDR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for KDR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P35968 | approved|investigational | DB00398 | Sorafenib | small molecule | P35968 |
| P35968 | approved|investigational | DB01268 | Sunitinib | small molecule | P35968 |
| P35968 | approved|investigational | DB05578 | Ramucirumab | biotech | P35968 |
| P35968 | approved | DB06589 | Pazopanib | small molecule | P35968 |
| P35968 | approved|investigational | DB06595 | Midostaurin | small molecule | P35968 |
| P35968 | approved|investigational | DB06626 | Axitinib | small molecule | P35968 |
| P35968 | approved|investigational | DB08875 | Cabozantinib | small molecule | P35968 |
| P35968 | approved | DB08896 | Regorafenib | small molecule | P35968 |
| P35968 | approved|investigational | DB08901 | Ponatinib | small molecule | P35968 |
| P35968 | approved|investigational | DB09078 | Lenvatinib | small molecule | P35968 |
| P35968 | approved | DB09079 | Nintedanib | small molecule | P35968 |
| P35968 | approved|investigational | DB12010 | Fostamatinib | small molecule | P35968 |
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RelatedDiseases for KDR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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