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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DND1 |
Gene summary |
Gene information | Gene symbol | DND1 | Gene ID | 373863 |
Gene name | DND microRNA-mediated repression inhibitor 1 | |
Synonyms | RBMS4 | |
Cytomap | 5q31.3 | |
Type of gene | protein-coding | |
Description | dead end protein homolog 1RNA-binding motif, single-stranded-interacting protein 4dead end homolog 1 | |
Modification date | 20200313 | |
UniProtAcc | Q8IYX4, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
DND1 | GO:0060965 | negative regulation of gene silencing by miRNA | 18155131 |
DND1 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 28297718 |
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Gene structures and expression levels for DND1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000503621.5 | CLDND1-209:protein_coding:CLDND1 | 1.223825e+01 | 9.564234e-01 | 7.852255e-04 | 1.223720e-02 |
PG | UP | ENST00000513287.5 | CLDND1-226:protein_coding:CLDND1 | 2.172086e+01 | 8.417452e-01 | 1.628019e-03 | 2.064672e-02 |
PG | UP | ENST00000506575.1 | CLDND1-211:protein_coding:CLDND1 | 3.460800e+00 | 1.513521e+00 | 4.087677e-03 | 3.967904e-02 |
PG | UP | ENST00000515620.5 | CLDND1-231:protein_coding:CLDND1 | 3.797913e+00 | 1.846344e+00 | 4.215835e-03 | 4.055348e-02 |
CB | DOWN | ENST00000513873.1 | CLDND1-228:protein_coding:CLDND1 | 1.682874e+01 | -4.047426e+00 | 2.992046e-13 | 5.513474e-11 |
CB | DOWN | ENST00000484455.1 | AXDND1-204:lncRNA:AXDND1 | 9.966843e-01 | -1.240177e+00 | 3.673741e-04 | 2.222342e-03 |
CB | UP | ENST00000513452.5 | CLDND1-227:protein_coding:CLDND1 | 2.677288e+00 | 2.509726e+00 | 6.749752e-03 | 2.516830e-02 |
TC | DOWN | ENST00000513873.1 | CLDND1-228:protein_coding:CLDND1 | 1.756533e+01 | -2.669061e+00 | 1.339640e-15 | 1.225812e-12 |
TC | UP | ENST00000513287.5 | CLDND1-226:protein_coding:CLDND1 | 1.019921e+02 | 9.651561e-01 | 1.954768e-08 | 1.568889e-06 |
TC | UP | ENST00000513452.5 | CLDND1-227:protein_coding:CLDND1 | 2.530794e+01 | 1.825523e+00 | 1.283840e-04 | 1.972576e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DND1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DND1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DND1 |
p-ENSG00000256453_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DND1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DND1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DND1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DND1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DND1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DND1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DND1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |