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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for AR |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AR | GO:0006351 | transcription, DNA-templated | 15572661 |
| AR | GO:0008284 | positive regulation of cell proliferation | 17277772 |
| AR | GO:0010628 | positive regulation of gene expression | 24681825 |
| AR | GO:0030521 | androgen receptor signaling pathway | 19886863|20048160 |
| AR | GO:0030522 | intracellular receptor signaling pathway | 17277772 |
| AR | GO:0045720 | negative regulation of integrin biosynthetic process | 21310825 |
| AR | GO:0045726 | positive regulation of integrin biosynthetic process | 21310825 |
| AR | GO:0045893 | positive regulation of transcription, DNA-templated | 11477070|12799378 |
| AR | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12799378|16728402|17505061|20048160|20181722 |
| AR | GO:0045945 | positive regulation of transcription by RNA polymerase III | 18487222 |
| AR | GO:1903076 | regulation of protein localization to plasma membrane | 21310825 |
| AR | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 21310825 |
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Gene structures and expression levels for AR |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000169083
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000354333.5 | TSPEAR-AS2-202:lncRNA:TSPEAR | 5.553475e+00 | 9.025962e-01 | 4.024249e-06 | 6.849348e-04 |
| STG | UP | ENST00000529168.2 | ADAR-208:protein_coding:ADAR | 1.930240e+01 | 2.358895e+01 | 1.306707e-19 | 2.279370e-16 |
| PG | UP | ENST00000630360.1 | PAUPAR-203:lncRNA:PAUPAR | 2.637476e+00 | 1.044744e+00 | 2.074279e-04 | 4.682102e-03 |
| PG | UP | ENST00000628648.2 | CFLAR-AS1-215:lncRNA:CFLAR | 2.299872e+00 | 1.061280e+00 | 2.793546e-04 | 5.821894e-03 |
| PG | UP | ENST00000627956.2 | CFLAR-AS1-213:lncRNA:CFLAR | 3.403834e+00 | 9.482589e-01 | 2.598963e-03 | 2.877928e-02 |
| PG | UP | ENST00000593896.1 | CFLAR-AS1-203:lncRNA:CFLAR | 3.600334e+00 | 8.511801e-01 | 2.675062e-03 | 2.938896e-02 |
| CB | UP | ENST00000341582.10 | CFLAR-204:protein_coding:CFLAR | 4.237403e+00 | 3.555182e+00 | 2.103873e-07 | 3.988423e-06 |
| CB | DOWN | ENST00000474303.5 | ANKAR-207:lncRNA:ANKAR | 4.732916e+00 | -1.048942e+00 | 2.704047e-07 | 4.927136e-06 |
| CB | DOWN | ENST00000648714.1 | ADAR-214:nonsense_mediated_decay:ADAR | 2.015871e+03 | -1.124116e+00 | 7.836666e-06 | 8.598611e-05 |
| CB | UP | ENST00000423241.6 | CFLAR-208:protein_coding:CFLAR | 4.447774e+01 | 8.629228e-01 | 9.856695e-05 | 7.314034e-04 |
| CB | UP | ENST00000563971.5 | BFAR-207:protein_coding:BFAR | 3.565676e+01 | 1.050137e+00 | 1.684154e-04 | 1.151069e-03 |
| CB | UP | ENST00000642614.1 | PAUPAR-206:lncRNA:PAUPAR | 1.903816e+01 | 1.384004e+00 | 5.147793e-04 | 2.952878e-03 |
| CB | UP | ENST00000643436.1 | PAUPAR-208:lncRNA:PAUPAR | 2.508978e+01 | 9.785919e-01 | 1.743167e-03 | 8.219100e-03 |
| CB | UP | ENST00000341222.10 | CFLAR-203:protein_coding:CFLAR | 5.955607e+01 | 8.075386e-01 | 2.782196e-03 | 1.212332e-02 |
| CB | UP | ENST00000417748.1 | CFLAR-207:protein_coding:CFLAR | 1.849774e+00 | 9.632915e-01 | 8.837828e-03 | 3.140959e-02 |
| TC | UP | ENST00000443779.3 | SPAAR-202:protein_coding:SPAAR | 5.565267e+01 | 8.087815e-01 | 5.332036e-06 | 1.568549e-04 |
| TC | DOWN | ENST00000615826.1 | PICSAR-201:lncRNA:PICSAR | 1.779481e+00 | -2.210307e+00 | 5.746109e-06 | 1.661362e-04 |
| TC | UP | ENST00000642237.1 | PAUPAR-204:lncRNA:PAUPAR | 1.206023e+00 | 1.823466e+00 | 4.926453e-04 | 5.687479e-03 |
| TC | UP | ENST00000644607.1 | PAUPAR-212:lncRNA:PAUPAR | 1.216345e+00 | 1.297896e+00 | 7.048351e-03 | 4.327525e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for AR |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for AR |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for AR |
p-ENSG00000169083_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in AR |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for AR |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for AR |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AR |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for AR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for AR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P10275 | approved|investigational | DB00255 | Diethylstilbestrol | small molecule | P10275 |
| P10275 | approved|investigational | DB00367 | Levonorgestrel | small molecule | P10275 |
| P10275 | approved|vet_approved | DB00396 | Progesterone | small molecule | P10275 |
| P10275 | approved | DB00421 | Spironolactone | small molecule | P10275 |
| P10275 | approved|investigational | DB00499 | Flutamide | small molecule | P10275 |
| P10275 | approved|investigational | DB00621 | Oxandrolone | small molecule | P10275 |
| P10275 | approved | DB00623 | Fluphenazine | small molecule | P10275 |
| P10275 | approved|investigational | DB00624 | Testosterone | small molecule | P10275 |
| P10275 | approved | DB00648 | Mitotane | small molecule | P10275 |
| P10275 | approved | DB00655 | Estrone | small molecule | P10275 |
| P10275 | approved|investigational | DB00665 | Nilutamide | small molecule | P10275 |
| P10275 | approved | DB00675 | Tamoxifen | small molecule | P10275 |
| P10275 | approved|investigational | DB00687 | Fludrocortisone | small molecule | P10275 |
| P10275 | approved|investigational | DB00957 | Norgestimate | small molecule | P10275 |
| P10275 | approved|investigational | DB01026 | Ketoconazole | small molecule | P10275 |
| P10275 | approved | DB01063 | Acetophenazine | small molecule | P10275 |
| P10275 | approved | DB01128 | Bicalutamide | small molecule | P10275 |
| P10275 | approved|illicit | DB01185 | Fluoxymesterone | small molecule | P10275 |
| P10275 | approved | DB01395 | Drospirenone | small molecule | P10275 |
| P10275 | approved | DB01406 | Danazol | small molecule | P10275 |
| P10275 | approved|investigational | DB01608 | Periciazine | small molecule | P10275 |
| P10275 | approved|investigational|nutraceutical | DB01708 | Prasterone | small molecule | P10275 |
| P10275 | approved | DB02266 | Flufenamic Acid | small molecule | P10275 |
| P10275 | approved|investigational | DB04839 | Cyproterone acetate | small molecule | P10275 |
| P10275 | approved|illicit | DB06412 | Oxymetholone | small molecule | P10275 |
| P10275 | approved | DB06710 | Methyltestosterone | small molecule | P10275 |
| P10275 | approved|investigational | DB06713 | Norelgestromin | small molecule | P10275 |
| P10275 | approved|investigational | DB08604 | Triclosan | small molecule | P10275 |
| P10275 | approved | DB08867 | Ulipristal | small molecule | P10275 |
| P10275 | approved | DB08899 | Enzalutamide | small molecule | P10275 |
| P10275 | approved | DB09123 | Dienogest | small molecule | P10275 |
| P10275 | approved | DB09371 | Norethynodrel | small molecule | P10275 |
| P10275 | approved | DB09389 | Norgestrel | small molecule | P10275 |
| P10275 | approved | DB11619 | Gestrinone | small molecule | P10275 |
| P10275 | approved|investigational | DB11901 | Apalutamide | small molecule | P10275 |
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RelatedDiseases for AR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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