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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for EIF3E |
 Gene summary |
| Gene information | Gene symbol | EIF3E | Gene ID | 3646 |
| Gene name | eukaryotic translation initiation factor 3 subunit E | |
| Synonyms | EIF3-P48|EIF3S6|INT6|eIF3-p46 | |
| Cytomap | 8q23.1 | |
| Type of gene | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit EeIF-3 p48eukaryotic translation initiation factor 3 subunit 6eukaryotic translation initiation factor 3 subunit E isoform 2 transcripteukaryotic translation initiation factor 3, subunit 6 (48kD)euka | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| EIF3E | GO:0006413 | translational initiation | 17581632 |
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Gene structures and expression levels for EIF3E |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000104408
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000518345.1 | EIF3E-203:protein_coding:EIF3E | 4.872461e+01 | 1.218552e+00 | 2.877858e-12 | 3.597053e-10 |
| CB | UP | ENST00000522445.5 | EIF3E-215:nonsense_mediated_decay:EIF3E | 8.534749e+01 | 9.317365e-01 | 1.231581e-06 | 1.786948e-05 |
| TC | DOWN | ENST00000522352.5 | EIF3E-214:protein_coding:EIF3E | 1.584655e+02 | -1.097665e+00 | 6.102598e-08 | 4.065128e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EIF3E |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104494 | chr8 | 108241893:108241913:108242112:108242256:108248613:108248668 | 108242112:108242256 |
| exon_skip_110949 | chr8 | 108236163:108236203:108239958:108240075:108248613:108248668 | 108239958:108240075 |
| exon_skip_121112 | chr8 | 108241799:108241913:108242112:108242346:108248613:108248668 | 108242112:108242346 |
| exon_skip_124571 | chr8 | 108239958:108240075:108241799:108241913:108248613:108248668 | 108241799:108241913 |
| exon_skip_142311 | chr8 | 108239958:108240075:108241799:108241913:108242112:108242256 | 108241799:108241913 |
| exon_skip_160091 | chr8 | 108236161:108236203:108241799:108241913:108248613:108248668 | 108241799:108241913 |
| exon_skip_164507 | chr8 | 108236163:108236203:108241799:108241913:108248613:108248668 | 108241799:108241913 |
| exon_skip_165244 | chr8 | 108236161:108236203:108239958:108240098:108241799:108241913 | 108239958:108240098 |
| exon_skip_188668 | chr8 | 108236161:108236203:108239958:108240098:108241799:108241818 | 108239958:108240098 |
| exon_skip_206117 | chr8 | 108236163:108236203:108239958:108240075:108241799:108241913 | 108239958:108240075 |
| exon_skip_23220 | chr8 | 108214607:108214716:108216412:108216513:108217334:108217460 | 108216412:108216513 |
| exon_skip_243735 | chr8 | 108236161:108236203:108239958:108240075:108241799:108241818 | 108239958:108240075 |
| exon_skip_245767 | chr8 | 108236163:108236203:108239958:108240098:108241799:108241913 | 108239958:108240098 |
| exon_skip_283685 | chr8 | 108241893:108241913:108242112:108242346:108248613:108248668 | 108242112:108242346 |
| exon_skip_41469 | chr8 | 108236161:108236203:108239958:108240075:108248613:108248668 | 108239958:108240075 |
| exon_skip_56549 | chr8 | 108241893:108241913:108242112:108242256:108248613:108248717 | 108242112:108242256 |
| exon_skip_61384 | chr8 | 108236161:108236203:108239958:108240075:108241799:108241913 | 108239958:108240075 |
| exon_skip_73662 | chr8 | 108216476:108216513:108217334:108217460:108228267:108228391 | 108217334:108217460 |
| exon_skip_86489 | chr8 | 108241893:108241913:108243293:108243463:108248613:108248668 | 108243293:108243463 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for EIF3E |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000220849 | 108239958 | 108240075 | Frame-shift |
| ENST00000220849 | 108241799 | 108241913 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000220849 | 108239958 | 108240075 | Frame-shift |
| ENST00000220849 | 108241799 | 108241913 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000220849 | 108217334 | 108217460 | Frame-shift |
| ENST00000220849 | 108239958 | 108240075 | Frame-shift |
| ENST00000220849 | 108241799 | 108241913 | Frame-shift |
| ENST00000220849 | 108216412 | 108216513 | In-frame |
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Infer the effects of exon skipping event on protein functional features for EIF3E |
p-ENSG00000104408_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000220849 | 1560 | 445 | 108216412 | 108216513 | 913 | 1013 | 283 | 316 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P60228 | 283 | 316 | 2 | 445 | Chain | ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E |
| P60228 | 283 | 316 | 221 | 398 | Domain | Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185 |
| P60228 | 283 | 316 | 281 | 289 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B |
| P60228 | 283 | 316 | 291 | 301 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B |
| P60228 | 283 | 316 | 305 | 319 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B |
| P60228 | 283 | 316 | 312 | 312 | Mutagenesis | Note=Promotes nuclear accumulation. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17761670;Dbxref=PMID:17761670 |
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3'-UTR located exon skipping events that lost miRNA binding sites in EIF3E |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for EIF3E |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for EIF3E |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF3E |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for EIF3E |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for EIF3E |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF3E |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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