Gene summary |
Gene information | Gene symbol | IL10RA |
Gene ID | 3587 | Gene name | interleukin 10 receptor subunit alpha |
Synonyms | CD210|CD210a|CDW210A|HIL-10R|IL-10R1|IL10R |
Cytomap | 11q23.3 |
Type of gene | protein-coding |
Description | interleukin-10 receptor subunit alphaIL-10 receptor subunit alphaIL-10R subunit 1IL-10R subunit alphaIL-10RAinterleukin 10 receptor, alphainterleukin-10 receptor alpha chaininterleukin-10 receptor subunit 1 |
Modification date | 20200313 |
UniProtAcc | E9PKU2, E9PPU4, H2DF05, Q13651, |
Context | |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000110324
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
STG | UP | 1.559243e+02 | 8.160806e-01 | 6.985891e-06 | 1.452149e-03 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000525467.1 | IL10RA-202:retained_intron:IL10RA | 7.017351e+00 | 1.059980e+00 | 4.017132e-04 | 2.434180e-02 |
PG | UP | ENST00000529924.6 | IL10RA-204:retained_intron:IL10RA | 5.323024e+01 | 8.152609e-01 | 1.479358e-07 | 2.045009e-05 |
PG | UP | ENST00000525467.1 | IL10RA-202:retained_intron:IL10RA | 7.565238e+00 | 8.495310e-01 | 2.746848e-05 | 1.056114e-03 |
PG | UP | ENST00000532009.1 | IL10RA-208:retained_intron:IL10RA | 2.296514e+00 | 1.188946e+00 | 1.744155e-04 | 4.117712e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_142500 | chr11 | 117986394:117986534:117986607:117986813:117988382:117988502 | 117986607:117986813 |
exon_skip_170536 | chr11 | 117986441:117986534:117986684:117986813:117988382:117988502 | 117986684:117986813 |
exon_skip_201479 | chr11 | 117986391:117986534:117986684:117986813:117988382:117988502 | 117986684:117986813 |
exon_skip_208503 | chr11 | 117988382:117988502:117989442:117989620:117993241:117993410 | 117989442:117989620 |
exon_skip_44004 | chr11 | 117986441:117986534:117986607:117986813:117988382:117988502 | 117986607:117986813 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000227752 | 117989442 | 117989620 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000227752 | 117989442 | 117989620 | Frame-shift |
p-ENSG00000110324_img4.png
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Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |