ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for IL6ST

Gene summary

Gene information	Gene symbol	IL6ST
	Gene ID	3572
	Gene name	interleukin 6 signal transducer
	Synonyms	CD130\|CDW130\|GP130\|HIES4\|IL-6RB\|sGP130
	Cytomap	5q11.2
	Type of gene	protein-coding
	Description	interleukin-6 receptor subunit betaCD130 antigenIL-6 receptor subunit betaIL-6R subunit betagp130 of the rheumatoid arthritis antigenic peptide-bearing soluble formgp130, oncostatin M receptorinterleukin receptor beta chainmembrane glycoprotein 130
	Modification date	20200327
	UniProtAcc	A0A0A0N0L2, A0A0A0N0L5, A0A494BZU0, D6RH03, P40189, Q17RA0, Q5FC02, Q5FC03, Q5FC05, Q5FC06, Q5FC07,
	Context	- 27384491(The Mitochondrial-Derived Peptide Humanin Activates the ERK1/2, AKT, and STAT3 Signaling Pathways and Has Age-Dependent Signaling Differences in the Hippocampus)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
IL6ST	GO:0008284	positive regulation of cell proliferation	2261637
IL6ST	GO:0019221	cytokine-mediated signaling pathway	2261637
IL6ST	GO:0034097	response to cytokine	2261637\|8999038
IL6ST	GO:0048861	leukemia inhibitory factor signaling pathway	8999038\|12643274
IL6ST	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	12643274

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Gene structures and expression levels for IL6ST

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000134352

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000381294.7	IL6ST-205:protein_coding:IL6ST	2.391587e+01	1.305698e+00	2.793412e-04	1.764679e-03
CB	UP	ENST00000583149.1	IL6ST-215:retained_intron:IL6ST	2.594426e+01	1.778321e+00	4.114544e-04	2.443503e-03
TC	UP	ENST00000381294.7	IL6ST-205:protein_coding:IL6ST	1.808268e+01	1.131783e+00	1.167411e-04	1.829604e-03
TC	UP	ENST00000583149.1	IL6ST-215:retained_intron:IL6ST	2.916515e+01	1.255888e+00	5.428611e-03	3.564892e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for IL6ST

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_12677	chr5	55947565:55947589:55948102:55948982:55951464:55951506	55948102:55948982
exon_skip_132159	chr5	55947565:55947589:55948102:55948982:55951464:55951604	55948102:55948982
exon_skip_138312	chr5	55963352:55963506:55964146:55964312:55968276:55968396	55964146:55964312
exon_skip_13923	chr5	55957209:55957291:55959626:55959671:55960402:55960480	55959626:55959671
exon_skip_14185	chr5	55954810:55954992:55956025:55956235:55957209:55957291	55956025:55956235
exon_skip_143382	chr5	55947565:55947589:55951464:55951604:55951929:55952075	55951464:55951604
exon_skip_143857	chr5	55968276:55968396:55969550:55969855:55976215:55976278	55969550:55969855
exon_skip_144446	chr5	55951929:55952075:55952250:55952351:55956025:55956235	55952250:55952351
exon_skip_153397	chr5	55952250:55952351:55954810:55954992:55956025:55956152	55954810:55954992
exon_skip_156796	chr5	55957209:55957291:55959626:55959671:55960402:55960561	55959626:55959671
exon_skip_163613	chr5	55954810:55954992:55956025:55956235:55960402:55960480	55956025:55956235
exon_skip_187984	chr5	55947493:55947589:55948102:55948982:55951464:55951577	55948102:55948982
exon_skip_201174	chr5	55952250:55952351:55954810:55954992:55956025:55956064	55954810:55954992
exon_skip_209581	chr5	55952250:55952351:55954810:55954992:55956025:55956235	55954810:55954992
exon_skip_214979	chr5	55956167:55956235:55957209:55957291:55960402:55960561	55957209:55957291
exon_skip_223884	chr5	55942670:55942751:55947493:55947589:55951464:55951506	55947493:55947589
exon_skip_254569	chr5	55956025:55956235:55957209:55957291:55960402:55960480	55957209:55957291
exon_skip_267927	chr5	55969760:55969855:55976215:55976293:55982724:55982800	55976215:55976293
exon_skip_287247	chr5	55963352:55963506:55964146:55964312:55968276:55968387	55964146:55964312
exon_skip_31053	chr5	55951464:55951604:55951929:55952075:55952250:55952351	55951929:55952075
exon_skip_46522	chr5	55976215:55976293:55982724:55982811:55994784:55994792	55982724:55982811
exon_skip_52200	chr5	55964209:55964312:55968276:55968396:55969550:55969855	55968276:55968396
exon_skip_66290	chr5	55951929:55952075:55952250:55952351:55954810:55954992	55952250:55952351
exon_skip_96500	chr5	55956195:55956235:55957209:55957291:55960402:55960561	55957209:55957291

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for IL6ST

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000381298	55976215	55976293	3UTR-3CDS
ENST00000336909	55947493	55947589	Frame-shift
ENST00000381298	55947493	55947589	Frame-shift
ENST00000502326	55947493	55947589	Frame-shift
ENST00000336909	55957209	55957291	Frame-shift
ENST00000381298	55957209	55957291	Frame-shift
ENST00000502326	55957209	55957291	Frame-shift
ENST00000336909	55964146	55964312	Frame-shift
ENST00000381298	55964146	55964312	Frame-shift
ENST00000502326	55964146	55964312	Frame-shift
ENST00000336909	55968276	55968396	Frame-shift
ENST00000381298	55968276	55968396	Frame-shift
ENST00000502326	55968276	55968396	Frame-shift
ENST00000336909	55951464	55951604	In-frame
ENST00000381298	55951464	55951604	In-frame
ENST00000502326	55951464	55951604	In-frame
ENST00000336909	55951929	55952075	In-frame
ENST00000381298	55951929	55952075	In-frame
ENST00000502326	55951929	55952075	In-frame
ENST00000336909	55952250	55952351	In-frame
ENST00000381298	55952250	55952351	In-frame
ENST00000502326	55952250	55952351	In-frame
ENST00000336909	55954810	55954992	In-frame
ENST00000381298	55954810	55954992	In-frame
ENST00000502326	55954810	55954992	In-frame
ENST00000336909	55969550	55969855	In-frame
ENST00000381298	55969550	55969855	In-frame
ENST00000502326	55969550	55969855	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000336909	55947493	55947589	Frame-shift
ENST00000381298	55947493	55947589	Frame-shift
ENST00000502326	55947493	55947589	Frame-shift
ENST00000336909	55957209	55957291	Frame-shift
ENST00000381298	55957209	55957291	Frame-shift
ENST00000502326	55957209	55957291	Frame-shift
ENST00000336909	55968276	55968396	Frame-shift
ENST00000381298	55968276	55968396	Frame-shift
ENST00000502326	55968276	55968396	Frame-shift
ENST00000336909	55951929	55952075	In-frame
ENST00000381298	55951929	55952075	In-frame
ENST00000502326	55951929	55952075	In-frame
ENST00000336909	55952250	55952351	In-frame
ENST00000381298	55952250	55952351	In-frame
ENST00000502326	55952250	55952351	In-frame
ENST00000336909	55954810	55954992	In-frame
ENST00000381298	55954810	55954992	In-frame
ENST00000502326	55954810	55954992	In-frame
ENST00000336909	55969550	55969855	In-frame
ENST00000381298	55969550	55969855	In-frame
ENST00000502326	55969550	55969855	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000336909	55947493	55947589	Frame-shift
ENST00000381298	55947493	55947589	Frame-shift
ENST00000502326	55947493	55947589	Frame-shift
ENST00000336909	55956025	55956235	Frame-shift
ENST00000381298	55956025	55956235	Frame-shift
ENST00000502326	55956025	55956235	Frame-shift
ENST00000336909	55957209	55957291	Frame-shift
ENST00000381298	55957209	55957291	Frame-shift
ENST00000502326	55957209	55957291	Frame-shift
ENST00000336909	55964146	55964312	Frame-shift
ENST00000381298	55964146	55964312	Frame-shift
ENST00000502326	55964146	55964312	Frame-shift
ENST00000336909	55968276	55968396	Frame-shift
ENST00000381298	55968276	55968396	Frame-shift
ENST00000502326	55968276	55968396	Frame-shift
ENST00000336909	55951464	55951604	In-frame
ENST00000381298	55951464	55951604	In-frame
ENST00000502326	55951464	55951604	In-frame
ENST00000336909	55951929	55952075	In-frame
ENST00000381298	55951929	55952075	In-frame
ENST00000502326	55951929	55952075	In-frame
ENST00000336909	55952250	55952351	In-frame
ENST00000381298	55952250	55952351	In-frame
ENST00000502326	55952250	55952351	In-frame
ENST00000336909	55954810	55954992	In-frame
ENST00000381298	55954810	55954992	In-frame
ENST00000502326	55954810	55954992	In-frame
ENST00000336909	55969550	55969855	In-frame
ENST00000381298	55969550	55969855	In-frame
ENST00000502326	55969550	55969855	In-frame

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Infer the effects of exon skipping event on protein functional features for IL6ST

p-ENSG00000134352_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000336909	8793	918	55969550	55969855	101	405	21	123
ENST00000381298	9074	918	55969550	55969855	378	682	21	123
ENST00000502326	3024	918	55969550	55969855	261	565	21	123
ENST00000336909	8793	918	55954810	55954992	1304	1485	422	483
ENST00000381298	9074	918	55954810	55954992	1581	1762	422	483
ENST00000502326	3024	918	55954810	55954992	1464	1645	422	483
ENST00000336909	8793	918	55952250	55952351	1487	1587	483	517
ENST00000381298	9074	918	55952250	55952351	1764	1864	483	517
ENST00000502326	3024	918	55952250	55952351	1647	1747	483	517
ENST00000336909	8793	918	55951929	55952075	1589	1734	517	566
ENST00000381298	9074	918	55951929	55952075	1866	2011	517	566
ENST00000502326	3024	918	55951929	55952075	1749	1894	517	566
ENST00000336909	8793	918	55951464	55951604	1736	1875	566	613
ENST00000381298	9074	918	55951464	55951604	2013	2152	566	613
ENST00000502326	3024	918	55951464	55951604	1896	2035	566	613

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000336909	8793	918	55969550	55969855	101	405	21	123
ENST00000381298	9074	918	55969550	55969855	378	682	21	123
ENST00000502326	3024	918	55969550	55969855	261	565	21	123
ENST00000336909	8793	918	55954810	55954992	1304	1485	422	483
ENST00000381298	9074	918	55954810	55954992	1581	1762	422	483
ENST00000502326	3024	918	55954810	55954992	1464	1645	422	483
ENST00000336909	8793	918	55952250	55952351	1487	1587	483	517
ENST00000381298	9074	918	55952250	55952351	1764	1864	483	517
ENST00000502326	3024	918	55952250	55952351	1647	1747	483	517
ENST00000336909	8793	918	55951929	55952075	1589	1734	517	566
ENST00000381298	9074	918	55951929	55952075	1866	2011	517	566
ENST00000502326	3024	918	55951929	55952075	1749	1894	517	566

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000336909	8793	918	55969550	55969855	101	405	21	123
ENST00000381298	9074	918	55969550	55969855	378	682	21	123
ENST00000502326	3024	918	55969550	55969855	261	565	21	123
ENST00000336909	8793	918	55954810	55954992	1304	1485	422	483
ENST00000381298	9074	918	55954810	55954992	1581	1762	422	483
ENST00000502326	3024	918	55954810	55954992	1464	1645	422	483
ENST00000336909	8793	918	55952250	55952351	1487	1587	483	517
ENST00000381298	9074	918	55952250	55952351	1764	1864	483	517
ENST00000502326	3024	918	55952250	55952351	1647	1747	483	517
ENST00000336909	8793	918	55951929	55952075	1589	1734	517	566
ENST00000381298	9074	918	55951929	55952075	1866	2011	517	566
ENST00000502326	3024	918	55951929	55952075	1749	1894	517	566
ENST00000336909	8793	918	55951464	55951604	1736	1875	566	613
ENST00000381298	9074	918	55951464	55951604	2013	2152	566	613
ENST00000502326	3024	918	55951464	55951604	1896	2035	566	613

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

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3'-UTR located exon skipping events that lost miRNA binding sites in IL6ST

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for IL6ST

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for IL6ST

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL6ST

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for IL6ST

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for IL6ST

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IL6ST

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for IL6ST

Gene structures and expression levels for IL6ST

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for IL6ST

Open reading frame (ORF) annotation in the exon skipping event for IL6ST

Infer the effects of exon skipping event on protein functional features for IL6ST

3'-UTR located exon skipping events that lost miRNA binding sites in IL6ST

SNVs in the skipped exons for IL6ST

AD stage-associated exon skippint events for IL6ST

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL6ST

Correlation with RNA binding proteins (RBPs) for IL6ST

RelatedDrugs for IL6ST

RelatedDiseases for IL6ST