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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for IKBKB |
 Gene summary |
| Gene information | Gene symbol | IKBKB | Gene ID | 3551 |
| Gene name | inhibitor of nuclear factor kappa B kinase subunit beta | |
| Synonyms | IKK-beta|IKK2|IKKB|IMD15|IMD15A|IMD15B|NFKBIKB | |
| Cytomap | 8p11.21 | |
| Type of gene | protein-coding | |
| Description | inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betainhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IKBKB | GO:0006468 | protein phosphorylation | 15084260|20434986 |
| IKBKB | GO:0018105 | peptidyl-serine phosphorylation | 21399639 |
| IKBKB | GO:0042325 | regulation of phosphorylation | 26212789 |
| IKBKB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055|23453807 |
| IKBKB | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 |
| IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
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Gene structures and expression levels for IKBKB |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000104365
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000522785.1 | IKBKB-225:lncRNA:IKBKB | 1.495399e+01 | 1.169568e+00 | 4.281094e-16 | 2.924365e-13 |
| CB | UP | ENST00000518647.5 | IKBKB-208:retained_intron:IKBKB | 1.578185e+01 | 8.937163e-01 | 1.818367e-06 | 2.493722e-05 |
| CB | UP | ENST00000517388.5 | IKBKB-203:nonsense_mediated_decay:IKBKB | 2.467530e+00 | 1.042194e+00 | 6.218286e-06 | 7.049887e-05 |
| CB | DOWN | ENST00000416505.6 | IKBKB-202:protein_coding:IKBKB | 8.947698e+01 | -1.654646e+00 | 1.126217e-03 | 5.711550e-03 |
| CB | DOWN | ENST00000522147.4 | IKBKB-223:protein_coding:IKBKB | 3.900183e+01 | -2.063862e+00 | 5.579466e-03 | 2.155298e-02 |
| CB | UP | ENST00000517917.5 | IKBKB-207:retained_intron:IKBKB | 2.996793e+00 | 1.325884e+00 | 1.333173e-02 | 4.386386e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for IKBKB |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_127106 | chr8 | 42306368:42306432:42308901:42309025:42314322:42314429 | 42308901:42309025 |
| exon_skip_150696 | chr8 | 42316710:42316904:42317710:42317771:42318552:42318675 | 42317710:42317771 |
| exon_skip_161286 | chr8 | 42316710:42316904:42317657:42317771:42318552:42318675 | 42317657:42317771 |
| exon_skip_187297 | chr8 | 42271436:42271469:42272083:42272205:42290156:42290273 | 42272083:42272205 |
| exon_skip_221754 | chr8 | 42271318:42271469:42272083:42272205:42288634:42288728 | 42272083:42272205 |
| exon_skip_259640 | chr8 | 42272083:42272205:42290156:42290273:42293443:42293512 | 42290156:42290273 |
| exon_skip_284285 | chr8 | 42319270:42319421:42319585:42319646:42320735:42320844 | 42319585:42319646 |
| exon_skip_30544 | chr8 | 42271436:42271469:42288634:42288728:42290156:42290273 | 42288634:42288728 |
| exon_skip_32289 | chr8 | 42290156:42290273:42293443:42293568:42305187:42305236 | 42293443:42293568 |
| exon_skip_40618 | chr8 | 42272083:42272205:42288634:42288728:42290156:42290273 | 42288634:42288728 |
| exon_skip_52977 | chr8 | 42325972:42326097:42329124:42329214:42330914:42331067 | 42329124:42329214 |
| exon_skip_61533 | chr8 | 42271318:42271469:42288634:42288728:42290156:42290273 | 42288634:42288728 |
| exon_skip_61720 | chr8 | 42271436:42271469:42272083:42272205:42288634:42288728 | 42272083:42272205 |
| exon_skip_65258 | chr8 | 42320735:42320844:42321896:42321945:42322054:42322153 | 42321896:42321945 |
| exon_skip_69871 | chr8 | 42290156:42290273:42293443:42293512:42305187:42305236 | 42293443:42293512 |
| exon_skip_83465 | chr8 | 42325970:42326097:42329124:42329214:42330914:42331067 | 42329124:42329214 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_284285 | Mayo_CB | 4.214634e-01 | 5.225974e-01 | -1.011340e-01 | 2.943130e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for IKBKB |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000520810 | 42288634 | 42288728 | Frame-shift |
| ENST00000520810 | 42308901 | 42309025 | Frame-shift |
| ENST00000520810 | 42319585 | 42319646 | Frame-shift |
| ENST00000520810 | 42329124 | 42329214 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000520810 | 42288634 | 42288728 | Frame-shift |
| ENST00000520810 | 42308901 | 42309025 | Frame-shift |
| ENST00000520810 | 42319585 | 42319646 | Frame-shift |
| ENST00000520810 | 42329124 | 42329214 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000520810 | 42288634 | 42288728 | Frame-shift |
| ENST00000520810 | 42293443 | 42293512 | Frame-shift |
| ENST00000520810 | 42308901 | 42309025 | Frame-shift |
| ENST00000520810 | 42317657 | 42317771 | Frame-shift |
| ENST00000520810 | 42319585 | 42319646 | Frame-shift |
| ENST00000520810 | 42321896 | 42321945 | Frame-shift |
| ENST00000520810 | 42329124 | 42329214 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for IKBKB |
p-ENSG00000104365_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in IKBKB |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for IKBKB |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for IKBKB |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IKBKB |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for IKBKB |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_127106 | -4.048426e-01 | 1.448012e-07 |
| CB | CNOT4 | exon_skip_127106 | -4.703762e-01 | 5.099936e-10 |
| CB | PCBP4 | exon_skip_127106 | 5.592433e-01 | 2.684307e-14 |
| CB | RBM45 | exon_skip_127106 | 6.718151e-01 | 5.912931e-22 |
| CB | RBM4 | exon_skip_127106 | -7.224349e-01 | 1.278266e-26 |
| CB | SRSF4 | exon_skip_284285 | -5.252414e-01 | 1.178257e-12 |
| CB | RBM4 | exon_skip_284285 | -6.476838e-01 | 2.799271e-20 |
| CB | RBM4B | exon_skip_284285 | -4.863794e-01 | 8.044937e-11 |
| CB | TARDBP | exon_skip_52977 | -4.688262e-01 | 4.584889e-10 |
| CB | TRA2A | exon_skip_52977 | -6.204303e-01 | 2.733460e-18 |
| CB | SNRPA | exon_skip_52977 | -4.008887e-01 | 1.636960e-07 |
| CB | RBM45 | exon_skip_52977 | 7.225298e-01 | 5.936721e-27 |
| TC | RBM4 | exon_skip_127106 | -4.655816e-01 | 1.032719e-09 |
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RelatedDrugs for IKBKB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O14920 | approved | DB00244 | Mesalazine | small molecule | O14920 |
| O14920 | approved | DB00795 | Sulfasalazine | small molecule | O14920 |
| O14920 | approved|vet_approved | DB00945 | Acetylsalicylic acid | small molecule | O14920 |
| O14920 | approved|investigational | DB00995 | Auranofin | small molecule | O14920 |
| O14920 | approved|investigational | DB01169 | Arsenic trioxide | small molecule | O14920 |
| O14920 | approved|investigational | DB06151 | Acetylcysteine | small molecule | O14920 |
| O14920 | approved|investigational | DB12010 | Fostamatinib | small molecule | O14920 |
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RelatedDiseases for IKBKB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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