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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NMNAT3 |
 Gene summary |
| Gene information | Gene symbol | NMNAT3 | Gene ID | 349565 |
| Gene name | nicotinamide nucleotide adenylyltransferase 3 | |
| Synonyms | FKSG76|PNAT-3|PNAT3 | |
| Cytomap | 3q23 | |
| Type of gene | protein-coding | |
| Description | nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nuc | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NMNAT3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000163864
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | DOWN | ENST00000505779.5 | NMNAT3-204:lncRNA:NMNAT3 | 8.407339e-01 | -1.825250e+00 | 1.573386e-06 | 5.816412e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NMNAT3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100527 | chr3 | 139578880:139579055:139582927:139583208:139627616:139627764 | 139582927:139583208 |
| exon_skip_102031 | chr3 | 139578880:139579055:139627616:139627764:139637963:139638062 | 139627616:139627764 |
| exon_skip_118771 | chr3 | 139627616:139627764:139637963:139638062:139677705:139677718 | 139637963:139638062 |
| exon_skip_152186 | chr3 | 139561333:139561392:139573598:139573680:139578872:139579055 | 139573598:139573680 |
| exon_skip_204785 | chr3 | 139561333:139561392:139572107:139572233:139573598:139573680 | 139572107:139572233 |
| exon_skip_232361 | chr3 | 139627616:139627764:139634611:139634647:139637963:139638062 | 139634611:139634647 |
| exon_skip_233293 | chr3 | 139561333:139561392:139573598:139573680:139575583:139575648 | 139573598:139573680 |
| exon_skip_241223 | chr3 | 139627616:139627761:139634611:139634647:139637963:139638062 | 139634611:139634647 |
| exon_skip_256362 | chr3 | 139561151:139561392:139572107:139572233:139573598:139573680 | 139572107:139572233 |
| exon_skip_276579 | chr3 | 139637963:139638062:139672603:139672712:139677705:139677918 | 139672603:139672712 |
| exon_skip_279921 | chr3 | 139561048:139561392:139578872:139579055:139627616:139627764 | 139578872:139579055 |
| exon_skip_281430 | chr3 | 139578872:139579055:139627616:139627764:139637963:139638062 | 139627616:139627764 |
| exon_skip_42309 | chr3 | 139573598:139573680:139575583:139575994:139578872:139579055 | 139575583:139575994 |
| exon_skip_45527 | chr3 | 139578872:139579055:139582927:139583208:139627616:139627764 | 139582927:139583208 |
| exon_skip_82073 | chr3 | 139560192:139561392:139578872:139579055:139627616:139627764 | 139578872:139579055 |
| exon_skip_96737 | chr3 | 139573633:139573680:139575583:139575994:139578872:139579055 | 139575583:139575994 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NMNAT3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296202 | 139627616 | 139627764 | 3UTR-3CDS |
| ENST00000296202 | 139637963 | 139638062 | 3UTR-3UTR |
| ENST00000296202 | 139573598 | 139573680 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296202 | 139627616 | 139627764 | 3UTR-3CDS |
| ENST00000296202 | 139637963 | 139638062 | 3UTR-3UTR |
| ENST00000296202 | 139573598 | 139573680 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296202 | 139627616 | 139627764 | 3UTR-3CDS |
| ENST00000296202 | 139637963 | 139638062 | 3UTR-3UTR |
| ENST00000296202 | 139573598 | 139573680 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NMNAT3 |
p-ENSG00000163864_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NMNAT3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6727-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-7106-3p | chr3:139638015-139638022 | 8mer-1a | chr3:139638000-139638022 | 163.00 | -25.84 |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4312 | chr3:139637978-139637985 | 8mer-1a | chr3:139637966-139637985 | 148.00 | -17.01 |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4722-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6794-3p | chr3:139637986-139637993 | 8mer-1a | chr3:139637986-139638006 | 153.00 | -20.82 |
| Mayo | ENST00000296202 | 139637963 | 139638062 | hsa-miR-10398-5p | chr3:139638008-139638015 | 8mer-1a | chr3:139637999-139638021 | 168.00 | -26.44 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6727-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-7106-3p | chr3:139638015-139638022 | 8mer-1a | chr3:139638000-139638022 | 163.00 | -25.84 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4312 | chr3:139637978-139637985 | 8mer-1a | chr3:139637966-139637985 | 148.00 | -17.01 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4722-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6794-3p | chr3:139637986-139637993 | 8mer-1a | chr3:139637986-139638006 | 153.00 | -20.82 |
| MSBB | ENST00000296202 | 139637963 | 139638062 | hsa-miR-10398-5p | chr3:139638008-139638015 | 8mer-1a | chr3:139637999-139638021 | 168.00 | -26.44 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6727-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-7106-3p | chr3:139638015-139638022 | 8mer-1a | chr3:139638000-139638022 | 163.00 | -25.84 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4312 | chr3:139637978-139637985 | 8mer-1a | chr3:139637966-139637985 | 148.00 | -17.01 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-4722-3p | chr3:139638036-139638043 | 8mer-1a | chr3:139638021-139638043 | 151.00 | -19.12 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-6794-3p | chr3:139637986-139637993 | 8mer-1a | chr3:139637986-139638006 | 153.00 | -20.82 |
| ROSMAP | ENST00000296202 | 139637963 | 139638062 | hsa-miR-10398-5p | chr3:139638008-139638015 | 8mer-1a | chr3:139637999-139638021 | 168.00 | -26.44 |
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SNVs in the skipped exons for NMNAT3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NMNAT3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NMNAT3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NMNAT3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NMNAT3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NMNAT3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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