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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIF24 |
 Gene summary |
| Gene information | Gene symbol | KIF24 | Gene ID | 347240 |
| Gene name | kinesin family member 24 | |
| Synonyms | C9orf48|bA571F15.4 | |
| Cytomap | 9p13.3 | |
| Type of gene | protein-coding | |
| Description | kinesin-like protein KIF24 | |
| Modification date | 20200313 | |
| UniProtAcc | Q5T7B8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KIF24 | GO:0007019 | microtubule depolymerization | 21620453 |
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Gene structures and expression levels for KIF24 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000186638
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIF24 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_19671 | chr9 | 34290174:34290389:34297017:34297114:34306252:34306441 | 34297017:34297114 |
| exon_skip_252606 | chr9 | 34259596:34259705:34263101:34263172:34269257:34269362 | 34263101:34263172 |
| exon_skip_28138 | chr9 | 34286617:34286704:34290174:34290389:34297017:34297114 | 34290174:34290389 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KIF24 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402558 | 34297017 | 34297114 | Frame-shift |
| ENST00000402558 | 34263101 | 34263172 | In-frame |
| ENST00000402558 | 34290174 | 34290389 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402558 | 34297017 | 34297114 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402558 | 34297017 | 34297114 | Frame-shift |
| ENST00000402558 | 34290174 | 34290389 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIF24 |
p-ENSG00000186638_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402558 | 6148 | 1368 | 34290174 | 34290389 | 937 | 1151 | 304 | 375 |
| ENST00000402558 | 6148 | 1368 | 34263101 | 34263172 | 1469 | 1539 | 481 | 504 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402558 | 6148 | 1368 | 34290174 | 34290389 | 937 | 1151 | 304 | 375 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5T7B8 | 304 | 375 | 209 | 1368 | Alternative sequence | ID=VSP_023211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q5T7B8 | 304 | 375 | 272 | 405 | Alternative sequence | ID=VSP_023210;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q5T7B8 | 304 | 375 | 1 | 1368 | Chain | ID=PRO_0000278248;Note=Kinesin-like protein KIF24 |
| Q5T7B8 | 304 | 375 | 223 | 546 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| Q5T7B8 | 304 | 375 | 313 | 320 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| Q5T7B8 | 481 | 504 | 209 | 1368 | Alternative sequence | ID=VSP_023211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q5T7B8 | 481 | 504 | 1 | 1368 | Chain | ID=PRO_0000278248;Note=Kinesin-like protein KIF24 |
| Q5T7B8 | 481 | 504 | 223 | 546 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| Q5T7B8 | 481 | 504 | 483 | 485 | Mutagenesis | Note=Impairs ability to suppress cilia formation. KEC->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21620453;Dbxref=PMID:21620453 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5T7B8 | 304 | 375 | 209 | 1368 | Alternative sequence | ID=VSP_023211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q5T7B8 | 304 | 375 | 272 | 405 | Alternative sequence | ID=VSP_023210;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q5T7B8 | 304 | 375 | 1 | 1368 | Chain | ID=PRO_0000278248;Note=Kinesin-like protein KIF24 |
| Q5T7B8 | 304 | 375 | 223 | 546 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| Q5T7B8 | 304 | 375 | 313 | 320 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIF24 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIF24 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIF24 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF24 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KIF24 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for KIF24 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF24 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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