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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NEK5 |
 Gene summary |
| Gene information | Gene symbol | NEK5 | Gene ID | 341676 |
| Gene name | NIMA related kinase 5 | |
| Synonyms | - | |
| Cytomap | 13q14.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase Nek5NIMA (never in mitosis gene a)-related kinase 5nimA-related protein kinase 5 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NEK5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197168
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NEK5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_117568 | chr13 | 52104498:52104552:52108318:52108404:52110340:52110577 | 52108318:52108404 |
| exon_skip_126327 | chr13 | 52076063:52076143:52082238:52082312:52083260:52083352 | 52082238:52082312 |
| exon_skip_131937 | chr13 | 52104498:52104552:52108318:52108404:52110340:52110410 | 52108318:52108404 |
| exon_skip_135407 | chr13 | 52071944:52072070:52075758:52075826:52076063:52076143 | 52075758:52075826 |
| exon_skip_163197 | chr13 | 52127366:52127504:52127595:52127662:52129029:52129078 | 52127595:52127662 |
| exon_skip_208845 | chr13 | 52076063:52076143:52083260:52083352:52086277:52086363 | 52083260:52083352 |
| exon_skip_224151 | chr13 | 52089247:52089313:52093054:52093235:52099743:52099876 | 52093054:52093235 |
| exon_skip_269940 | chr13 | 52037080:52037218:52050104:52050221:52061819:52061953 | 52050104:52050221 |
| exon_skip_296618 | chr13 | 52112268:52112365:52119319:52119415:52127366:52127482 | 52119319:52119415 |
| exon_skip_4705 | chr13 | 52087338:52087454:52089247:52089313:52093054:52093235 | 52089247:52089313 |
| exon_skip_59589 | chr13 | 52119319:52119415:52127366:52127504:52129029:52129092 | 52127366:52127504 |
| exon_skip_71499 | chr13 | 52110494:52110577:52112268:52112365:52119319:52119415 | 52112268:52112365 |
| exon_skip_98331 | chr13 | 52127366:52127504:52127595:52127662:52129029:52129067 | 52127595:52127662 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NEK5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355568 | 52127595 | 52127662 | 3UTR-3UTR |
| ENST00000355568 | 52093054 | 52093235 | Frame-shift |
| ENST00000617045 | 52093054 | 52093235 | Frame-shift |
| ENST00000355568 | 52112268 | 52112365 | Frame-shift |
| ENST00000617045 | 52112268 | 52112365 | Frame-shift |
| ENST00000355568 | 52119319 | 52119415 | Frame-shift |
| ENST00000617045 | 52119319 | 52119415 | Frame-shift |
| ENST00000355568 | 52075758 | 52075826 | In-frame |
| ENST00000617045 | 52075758 | 52075826 | In-frame |
| ENST00000355568 | 52082238 | 52082312 | In-frame |
| ENST00000617045 | 52082238 | 52082312 | In-frame |
| ENST00000355568 | 52108318 | 52108404 | In-frame |
| ENST00000617045 | 52108318 | 52108404 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355568 | 52127595 | 52127662 | 3UTR-3UTR |
| ENST00000355568 | 52093054 | 52093235 | Frame-shift |
| ENST00000617045 | 52093054 | 52093235 | Frame-shift |
| ENST00000355568 | 52112268 | 52112365 | Frame-shift |
| ENST00000617045 | 52112268 | 52112365 | Frame-shift |
| ENST00000355568 | 52119319 | 52119415 | Frame-shift |
| ENST00000617045 | 52119319 | 52119415 | Frame-shift |
| ENST00000355568 | 52108318 | 52108404 | In-frame |
| ENST00000617045 | 52108318 | 52108404 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355568 | 52127595 | 52127662 | 3UTR-3UTR |
| ENST00000355568 | 52089247 | 52089313 | Frame-shift |
| ENST00000617045 | 52089247 | 52089313 | Frame-shift |
| ENST00000355568 | 52093054 | 52093235 | Frame-shift |
| ENST00000617045 | 52093054 | 52093235 | Frame-shift |
| ENST00000355568 | 52112268 | 52112365 | Frame-shift |
| ENST00000617045 | 52112268 | 52112365 | Frame-shift |
| ENST00000355568 | 52119319 | 52119415 | Frame-shift |
| ENST00000617045 | 52119319 | 52119415 | Frame-shift |
| ENST00000355568 | 52075758 | 52075826 | In-frame |
| ENST00000617045 | 52075758 | 52075826 | In-frame |
| ENST00000355568 | 52082238 | 52082312 | In-frame |
| ENST00000617045 | 52082238 | 52082312 | In-frame |
| ENST00000355568 | 52108318 | 52108404 | In-frame |
| ENST00000617045 | 52108318 | 52108404 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NEK5 |
p-ENSG00000197168_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355568 | 2935 | 708 | 52108318 | 52108404 | 608 | 693 | 156 | 184 |
| ENST00000617045 | 2144 | 708 | 52108318 | 52108404 | 468 | 553 | 156 | 184 |
| ENST00000355568 | 2935 | 708 | 52082238 | 52082312 | 1713 | 1786 | 524 | 548 |
| ENST00000617045 | 2144 | 708 | 52082238 | 52082312 | 1573 | 1646 | 524 | 548 |
| ENST00000355568 | 2935 | 708 | 52075758 | 52075826 | 1869 | 1936 | 576 | 598 |
| ENST00000617045 | 2144 | 708 | 52075758 | 52075826 | 1729 | 1796 | 576 | 598 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355568 | 2935 | 708 | 52108318 | 52108404 | 608 | 693 | 156 | 184 |
| ENST00000617045 | 2144 | 708 | 52108318 | 52108404 | 468 | 553 | 156 | 184 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355568 | 2935 | 708 | 52108318 | 52108404 | 608 | 693 | 156 | 184 |
| ENST00000617045 | 2144 | 708 | 52108318 | 52108404 | 468 | 553 | 156 | 184 |
| ENST00000355568 | 2935 | 708 | 52082238 | 52082312 | 1713 | 1786 | 524 | 548 |
| ENST00000617045 | 2144 | 708 | 52082238 | 52082312 | 1573 | 1646 | 524 | 548 |
| ENST00000355568 | 2935 | 708 | 52075758 | 52075826 | 1869 | 1936 | 576 | 598 |
| ENST00000617045 | 2144 | 708 | 52075758 | 52075826 | 1729 | 1796 | 576 | 598 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P3R8 | 524 | 548 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 524 | 548 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 524 | 548 | 531 | 531 | Natural variant | ID=VAR_040923;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q6P3R8 | 524 | 548 | 531 | 531 | Natural variant | ID=VAR_040923;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q6P3R8 | 576 | 598 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 576 | 598 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P3R8 | 156 | 184 | 4 | 259 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P3R8 | 524 | 548 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 524 | 548 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 524 | 548 | 531 | 531 | Natural variant | ID=VAR_040923;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q6P3R8 | 524 | 548 | 531 | 531 | Natural variant | ID=VAR_040923;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q6P3R8 | 576 | 598 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
| Q6P3R8 | 576 | 598 | 1 | 708 | Chain | ID=PRO_0000259765;Note=Serine/threonine-protein kinase Nek5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in NEK5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6809-5p | chr13:52127617-52127624 | 8mer-1a | chr13:52127605-52127624 | 148.00 | -21.72 |
| Mayo | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6818-3p | chr13:52127629-52127636 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
| Mayo | ENST00000355568 | 52127595 | 52127662 | hsa-miR-593-3p | chr13:52127628-52127635 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
| MSBB | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6809-5p | chr13:52127617-52127624 | 8mer-1a | chr13:52127605-52127624 | 148.00 | -21.72 |
| MSBB | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6818-3p | chr13:52127629-52127636 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
| MSBB | ENST00000355568 | 52127595 | 52127662 | hsa-miR-593-3p | chr13:52127628-52127635 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
| ROSMAP | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6809-5p | chr13:52127617-52127624 | 8mer-1a | chr13:52127605-52127624 | 148.00 | -21.72 |
| ROSMAP | ENST00000355568 | 52127595 | 52127662 | hsa-miR-6818-3p | chr13:52127629-52127636 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
| ROSMAP | ENST00000355568 | 52127595 | 52127662 | hsa-miR-593-3p | chr13:52127628-52127635 | 8mer-1a | chr13:52127620-52127645 | 162.00 | -19.89 |
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SNVs in the skipped exons for NEK5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NEK5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NEK5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NEK5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NEK5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q6P3R8 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q6P3R8 |
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RelatedDiseases for NEK5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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