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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZDHHC21 |
 Gene summary |
| Gene information | Gene symbol | ZDHHC21 | Gene ID | 340481 |
| Gene name | zinc finger DHHC-type palmitoyltransferase 21 | |
| Synonyms | DHHC-21|DHHC21|DNZ1|HSPC097 | |
| Cytomap | 9p22.3 | |
| Type of gene | protein-coding | |
| Description | palmitoyltransferase ZDHHC21zinc finger DHHC-type containing 21zinc finger, DHHC domain containing 21 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8IVQ6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ZDHHC21 | GO:0018345 | protein palmitoylation | 23034182 |
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Gene structures and expression levels for ZDHHC21 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000175893
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZDHHC21 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_198098 | chr9 | 14639896:14640012:14658749:14658887:14662215:14662326 | 14658749:14658887 |
| exon_skip_213118 | chr9 | 14619639:14619682:14639896:14640012:14658749:14658887 | 14639896:14640012 |
| exon_skip_235805 | chr9 | 14674187:14674385:14680033:14680162:14690337:14690385 | 14680033:14680162 |
| exon_skip_278453 | chr9 | 14680033:14680162:14683571:14683729:14690337:14690385 | 14683571:14683729 |
| exon_skip_7268 | chr9 | 14674304:14674385:14680033:14680162:14690337:14690385 | 14680033:14680162 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZDHHC21 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380916 | 14639896 | 14640012 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380916 | 14680033 | 14680162 | 3UTR-3UTR |
| ENST00000380916 | 14639896 | 14640012 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380916 | 14680033 | 14680162 | 3UTR-3UTR |
| ENST00000380916 | 14658749 | 14658887 | Frame-shift |
| ENST00000380916 | 14639896 | 14640012 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZDHHC21 |
p-ENSG00000175893_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380916 | 9177 | 265 | 14639896 | 14640012 | 972 | 1087 | 168 | 206 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380916 | 9177 | 265 | 14639896 | 14640012 | 972 | 1087 | 168 | 206 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380916 | 9177 | 265 | 14639896 | 14640012 | 972 | 1087 | 168 | 206 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVQ6 | 168 | 206 | 1 | 265 | Chain | ID=PRO_0000212908;Note=Palmitoyltransferase ZDHHC21 |
| Q8IVQ6 | 168 | 206 | 186 | 206 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVQ6 | 168 | 206 | 1 | 265 | Chain | ID=PRO_0000212908;Note=Palmitoyltransferase ZDHHC21 |
| Q8IVQ6 | 168 | 206 | 186 | 206 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVQ6 | 168 | 206 | 1 | 265 | Chain | ID=PRO_0000212908;Note=Palmitoyltransferase ZDHHC21 |
| Q8IVQ6 | 168 | 206 | 186 | 206 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZDHHC21 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000380916 | 14680033 | 14680162 | hsa-miR-190b-3p | chr9:14680078-14680085 | 8mer-1a | chr9:14680066-14680086 | 178.00 | -23.03 |
| Mayo | ENST00000380916 | 14680033 | 14680162 | hsa-miR-9902 | chr9:14680065-14680072 | 8mer-1a | chr9:14680050-14680074 | 147.00 | -17.66 |
| Mayo | ENST00000380916 | 14680033 | 14680162 | hsa-miR-4709-3p | chr9:14680135-14680142 | 8mer-1a | chr9:14680120-14680142 | 152.00 | -16.26 |
| Mayo | ENST00000380916 | 14680033 | 14680162 | hsa-miR-520f-5p | chr9:14680080-14680087 | 8mer-1a | chr9:14680069-14680090 | 162.00 | -14.39 |
| MSBB | ENST00000380916 | 14680033 | 14680162 | hsa-miR-190b-3p | chr9:14680078-14680085 | 8mer-1a | chr9:14680066-14680086 | 178.00 | -23.03 |
| MSBB | ENST00000380916 | 14680033 | 14680162 | hsa-miR-9902 | chr9:14680065-14680072 | 8mer-1a | chr9:14680050-14680074 | 147.00 | -17.66 |
| MSBB | ENST00000380916 | 14680033 | 14680162 | hsa-miR-4709-3p | chr9:14680135-14680142 | 8mer-1a | chr9:14680120-14680142 | 152.00 | -16.26 |
| MSBB | ENST00000380916 | 14680033 | 14680162 | hsa-miR-520f-5p | chr9:14680080-14680087 | 8mer-1a | chr9:14680069-14680090 | 162.00 | -14.39 |
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SNVs in the skipped exons for ZDHHC21 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZDHHC21 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_207500 | 3.886289e-01 | 4.097272e-02 | chr9 | - | 14639896 | 14640012 | 14652738 | 14652835 | 14658749 | 14658887 |
| CDR | MSBB | IFG | exon_skip_207500 | 5.369796e-01 | 3.216007e-03 | chr9 | - | 14639896 | 14640012 | 14652738 | 14652835 | 14658749 | 14658887 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZDHHC21 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZDHHC21 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZDHHC21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZDHHC21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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