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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TREML1 |
 Gene summary |
| Gene information | Gene symbol | TREML1 | Gene ID | 340205 |
| Gene name | triggering receptor expressed on myeloid cells like 1 | |
| Synonyms | GLTL1825|PRO3438|TLT-1|TLT1|dJ238O23.3 | |
| Cytomap | 6p21.1 | |
| Type of gene | protein-coding | |
| Description | trem-like transcript 1 proteintriggering receptor expressed on myeloid cells-like protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q86YW5, | |
| Context | - 27939925(A Candidate Regulatory Variant at the TREM Gene Cluster Associates With Decreased Alzheimer's Disease Risk and Increased TREML1 and TREM2 Brain Gene Expression) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TREML1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000161911
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TREML1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_264021 | chr6 | 41149804:41149918:41150261:41150313:41150819:41150872 | 41150261:41150313 |
| exon_skip_278001 | chr6 | 41149804:41149918:41150261:41150313:41150819:41150907 | 41150261:41150313 |
| exon_skip_95467 | chr6 | 41151282:41151384:41153758:41154090:41154246:41154332 | 41153758:41154090 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TREML1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426005 | 41150261 | 41150313 | Frame-shift |
| ENST00000426005 | 41153758 | 41154090 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426005 | 41150261 | 41150313 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TREML1 |
p-ENSG00000161911_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000426005 | 998 | 311 | 41153758 | 41154090 | 88 | 419 | 14 | 125 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86YW5 | 14 | 125 | 15 | 125 | Alternative sequence | ID=VSP_021124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q86YW5 | 14 | 125 | 24 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 34 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 47 | 55 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 58 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 70 | 73 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 77 | 83 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 86 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 100 | 108 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 111 | 122 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 16 | 311 | Chain | ID=PRO_0000253855;Note=Trem-like transcript 1 protein |
| Q86YW5 | 14 | 125 | 38 | 104 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 52 | 59 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 16 | 121 | Domain | Note=Ig-like V-type |
| Q86YW5 | 14 | 125 | 42 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 96 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 1 | 15 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 16 | 162 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 74 | 76 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TREML1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TREML1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TREML1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TREML1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TREML1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TREML1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TREML1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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