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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF260 |
 Gene summary |
| Gene information | Gene symbol | ZNF260 | Gene ID | 339324 |
| Gene name | zinc finger protein 260 | |
| Synonyms | OZRF1|PEX1|ZFP260 | |
| Cytomap | 19q13.12 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 260zfp-260 | |
| Modification date | 20200313 | |
| UniProtAcc | L8E9K3, Q3ZCT1, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF260 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000254004
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000592282.1 | ZNF260-204:protein_coding:ZNF260 | 2.299353e+01 | 1.359071e+00 | 1.054855e-05 | 1.101874e-04 |
| CB | UP | ENST00000520608.2 | ZNF260-201:retained_intron:ZNF260 | 3.834011e+00 | 1.137478e+00 | 3.594942e-05 | 3.112833e-04 |
| TC | UP | ENST00000520608.2 | ZNF260-201:retained_intron:ZNF260 | 1.943769e+00 | 1.151359e+00 | 2.443239e-03 | 1.953487e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF260 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_208885 | chr19 | 36515650:36515699:36517286:36517393:36525155:36525299 | 36517286:36517393 |
| exon_skip_243608 | chr19 | 36511028:36515699:36518030:36518143:36525155:36525299 | 36518030:36518143 |
| exon_skip_245143 | chr19 | 36511028:36515699:36518030:36518143:36525155:36525373 | 36518030:36518143 |
| exon_skip_34122 | chr19 | 36515650:36515699:36518030:36518143:36525155:36525299 | 36518030:36518143 |
| exon_skip_35450 | chr19 | 36518030:36518143:36525155:36525373:36528219:36528265 | 36525155:36525373 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF260 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000592282 | 36518030 | 36518143 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000592282 | 36518030 | 36518143 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000588993 | 36517286 | 36517393 | 3UTR-3UTR |
| ENST00000592282 | 36518030 | 36518143 | 3UTR-3UTR |
| ENST00000592282 | 36525155 | 36525373 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF260 |
p-ENSG00000254004_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF260 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-6728-5p | chr19:36525299-36525306 | 8mer-1a | chr19:36525297-36525319 | 160.00 | -20.14 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-4418 | chr19:36517332-36517339 | 8mer-1a | chr19:36517319-36517339 | 149.00 | -18.21 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-199a-5p | chr19:36525261-36525268 | 8mer-1a | chr19:36525252-36525274 | 159.00 | -20.07 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-4753-3p | chr19:36525176-36525183 | 8mer-1a | chr19:36525162-36525186 | 163.00 | -23.00 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-7162-5p | chr19:36525363-36525370 | 8mer-1a | chr19:36525353-36525370 | 146.00 | -13.40 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-3664-5p | chr19:36517375-36517382 | 8mer-1a | chr19:36517362-36517382 | 142.00 | -21.32 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-345-3p | chr19:36525309-36525316 | 8mer-1a | chr19:36525297-36525319 | 160.00 | -20.14 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-1273h-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-6773-3p | chr19:36517372-36517379 | 8mer-1a | chr19:36517362-36517382 | 142.00 | -21.32 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6779-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6780a-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-6793-3p | chr19:36525282-36525289 | 8mer-1a | chr19:36525270-36525289 | 145.00 | -20.68 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-516b-3p | chr19:36525363-36525370 | 8mer-1a | chr19:36525353-36525370 | 146.00 | -13.40 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-516a-3p | chr19:36525363-36525370 | 8mer-1a | chr19:36525353-36525370 | 146.00 | -13.40 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-4433a-3p | chr19:36518053-36518060 | 8mer-1a | chr19:36518039-36518060 | 142.00 | -18.12 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-4437 | chr19:36517313-36517320 | 8mer-1a | chr19:36517298-36517324 | 152.00 | -28.01 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-6513-5p | chr19:36525300-36525307 | 8mer-1a | chr19:36525297-36525319 | 160.00 | -20.14 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-125b-2-3p | chr19:36525242-36525249 | 8mer-1a | chr19:36525225-36525250 | 150.00 | -16.93 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-6818-5p | chr19:36525170-36525177 | 8mer-1a | chr19:36525157-36525177 | 166.00 | -24.55 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-6828-3p | chr19:36525248-36525255 | 8mer-1a | chr19:36525248-36525268 | 146.00 | -19.50 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-7977 | chr19:36518094-36518101 | 8mer-1a | chr19:36518094-36518115 | 155.00 | -22.03 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-887-5p | chr19:36518084-36518091 | 8mer-1a | chr19:36518081-36518107 | 155.00 | -18.26 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-3691-3p | chr19:36525267-36525274 | 8mer-1a | chr19:36525252-36525274 | 159.00 | -20.07 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-153-5p | chr19:36525254-36525261 | 8mer-1a | chr19:36525252-36525274 | 159.00 | -20.07 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-383-3p | chr19:36525228-36525235 | 8mer-1a | chr19:36525225-36525250 | 150.00 | -16.93 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-30b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-939-3p | chr19:36517316-36517323 | 8mer-1a | chr19:36517298-36517324 | 152.00 | -28.01 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-199b-5p | chr19:36525261-36525268 | 8mer-1a | chr19:36525252-36525274 | 159.00 | -20.07 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689c | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689a-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-106a-3p | chr19:36517354-36517361 | 8mer-1a | chr19:36517345-36517368 | 158.00 | -21.36 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-509-5p | chr19:36517332-36517339 | 8mer-1a | chr19:36517319-36517339 | 149.00 | -18.21 |
| Mayo | ENST00000588993 | 36517286 | 36517393 | hsa-miR-509-3-5p | chr19:36517332-36517339 | 8mer-1a | chr19:36517319-36517339 | 149.00 | -18.21 |
| Mayo | ENST00000592282 | 36525155 | 36525373 | hsa-miR-767-3p | chr19:36525247-36525254 | 8mer-1a | chr19:36525236-36525255 | 151.00 | -13.83 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-1273h-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6779-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6780a-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-4433a-3p | chr19:36518053-36518060 | 8mer-1a | chr19:36518039-36518060 | 142.00 | -18.12 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-7977 | chr19:36518094-36518101 | 8mer-1a | chr19:36518094-36518115 | 155.00 | -22.03 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-887-5p | chr19:36518084-36518091 | 8mer-1a | chr19:36518081-36518107 | 155.00 | -18.26 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-30b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689c | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689a-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| MSBB | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-1273h-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6779-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-6780a-5p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-4433a-3p | chr19:36518053-36518060 | 8mer-1a | chr19:36518039-36518060 | 142.00 | -18.12 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-7977 | chr19:36518094-36518101 | 8mer-1a | chr19:36518094-36518115 | 155.00 | -22.03 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-887-5p | chr19:36518084-36518091 | 8mer-1a | chr19:36518081-36518107 | 155.00 | -18.26 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-30b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689c | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689a-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
| ROSMAP | ENST00000592282 | 36518030 | 36518143 | hsa-miR-3689b-3p | chr19:36518083-36518090 | 8mer-1a | chr19:36518070-36518090 | 173.00 | -28.94 |
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SNVs in the skipped exons for ZNF260 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF260 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF260 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF260 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF260 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF260 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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