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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for C17orf67 |
Gene summary |
Gene information | Gene symbol | C17orf67 | Gene ID | 339210 |
Gene name | chromosome 17 open reading frame 67 | |
Synonyms | - | |
Cytomap | 17q22 | |
Type of gene | protein-coding | |
Description | uncharacterized protein C17orf67 | |
Modification date | 20200313 | |
UniProtAcc | Q0P5P2, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for C17orf67 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000570754.5 | C17orf67-203:retained_intron:C17orf67 | 1.032341e+01 | -1.415059e+00 | 9.094790e-05 | 6.838157e-04 |
CB | UP | ENST00000487705.1 | C17orf67-202:lncRNA:C17orf67 | 1.080867e+00 | 8.722251e-01 | 3.547499e-03 | 1.481418e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for C17orf67 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_284172 | chr17 | 56824747:56824853:56825081:56825321:56832898:56833342 | 56825081:56825321 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for C17orf67 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000397861 | 56825081 | 56825321 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for C17orf67 |
p-ENSG00000214226_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in C17orf67 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-1290 | chr17:56825194-56825201 | 8mer-1a | chr17:56825186-56825207 | 157.00 | -16.47 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-6500-5p | chr17:56825110-56825117 | 8mer-1a | chr17:56825096-56825120 | 176.00 | -30.17 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-4711-5p | chr17:56825178-56825185 | 8mer-1a | chr17:56825159-56825185 | 143.00 | -14.13 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-144-5p | chr17:56825298-56825305 | 8mer-1a | chr17:56825285-56825305 | 150.00 | -11.58 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-4433a-3p | chr17:56825285-56825292 | 8mer-1a | chr17:56825268-56825292 | 146.00 | -21.73 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-4795-5p | chr17:56825115-56825122 | 8mer-1a | chr17:56825100-56825122 | 153.00 | -13.24 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-571 | chr17:56825273-56825280 | 8mer-1a | chr17:56825268-56825292 | 146.00 | -21.73 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-4633-3p | chr17:56825110-56825117 | 8mer-1a | chr17:56825096-56825120 | 176.00 | -30.17 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-146a-3p | chr17:56825132-56825139 | 8mer-1a | chr17:56825131-56825151 | 163.00 | -26.62 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-8056 | chr17:56825196-56825203 | 8mer-1a | chr17:56825196-56825218 | 157.00 | -24.21 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-6841-5p | chr17:56825211-56825218 | 8mer-1a | chr17:56825196-56825218 | 157.00 | -24.21 |
Mayo | ENST00000397861 | 56825081 | 56825321 | hsa-miR-676-5p | chr17:56825223-56825230 | 8mer-1a | chr17:56825222-56825245 | 158.00 | -13.60 |
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SNVs in the skipped exons for C17orf67 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for C17orf67 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for C17orf67 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for C17orf67 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for C17orf67 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C17orf67 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |