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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ICAM2 |
Gene summary |
Gene information | Gene symbol | ICAM2 | Gene ID | 3384 |
Gene name | intercellular adhesion molecule 2 | |
Synonyms | CD102 | |
Cytomap | 17q23.3 | |
Type of gene | protein-coding | |
Description | intercellular adhesion molecule 2ICAM-2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ICAM2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000580389.1 | ICAM2-210:retained_intron:ICAM2 | 2.542067e+00 | 1.134961e+00 | 4.762171e-03 | 1.890737e-02 |
CB | DOWN | ENST00000583684.5 | ICAM2-214:nonsense_mediated_decay:ICAM2 | 2.380061e+00 | -3.195555e+00 | 1.288382e-02 | 4.270491e-02 |
TC | UP | ENST00000584084.1 | ICAM2-215:protein_coding:ICAM2 | 1.534717e+01 | 1.170846e+00 | 9.271296e-04 | 9.330035e-03 |
TC | UP | ENST00000583366.5 | ICAM2-213:protein_coding:ICAM2 | 3.451501e+00 | 1.505698e+00 | 4.618436e-03 | 3.156682e-02 |
TC | DOWN | ENST00000583684.5 | ICAM2-214:nonsense_mediated_decay:ICAM2 | 2.471067e+00 | -2.724221e+00 | 4.950171e-03 | 3.326944e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ICAM2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_127179 | chr17 | 64006631:64006735:64007741:64007822:64020523:64020551 | 64007741:64007822 |
exon_skip_14584 | chr17 | 64005324:64005373:64006378:64006493:64006631:64006746 | 64006378:64006493 |
exon_skip_163086 | chr17 | 64005107:64005373:64006378:64006493:64006631:64006671 | 64006378:64006493 |
exon_skip_177436 | chr17 | 64006631:64006735:64007741:64007822:64020406:64020579 | 64007741:64007822 |
exon_skip_22104 | chr17 | 64005324:64005373:64006378:64006493:64006631:64006671 | 64006378:64006493 |
exon_skip_246212 | chr17 | 64003870:64003964:64004050:64004215:64005107:64005137 | 64004050:64004215 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ICAM2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000412356 | 64007741 | 64007822 | 3UTR-3UTR |
ENST00000579687 | 64007741 | 64007822 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000412356 | 64007741 | 64007822 | 3UTR-3UTR |
ENST00000579687 | 64007741 | 64007822 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ICAM2 |
p-ENSG00000108622_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ICAM2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-4254 | chr17:64007766-64007773 | 8mer-1a | chr17:64007761-64007781 | 156.00 | -21.59 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3155a | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3155b | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-484 | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-6797-5p | chr17:64007763-64007770 | 8mer-1a | chr17:64007742-64007770 | 164.00 | -26.40 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-1249-5p | chr17:64007763-64007770 | 8mer-1a | chr17:64007742-64007770 | 164.00 | -26.40 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-548ah-5p | chr17:64007812-64007819 | 8mer-1a | chr17:64007803-64007821 | 158.00 | -12.31 |
Mayo | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3609 | chr17:64007812-64007819 | 8mer-1a | chr17:64007803-64007821 | 158.00 | -12.31 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-4254 | chr17:64007766-64007773 | 8mer-1a | chr17:64007761-64007781 | 156.00 | -21.59 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3155a | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3155b | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-484 | chr17:64007798-64007805 | 8mer-1a | chr17:64007785-64007805 | 162.00 | -35.15 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-6797-5p | chr17:64007763-64007770 | 8mer-1a | chr17:64007742-64007770 | 164.00 | -26.40 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-1249-5p | chr17:64007763-64007770 | 8mer-1a | chr17:64007742-64007770 | 164.00 | -26.40 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-548ah-5p | chr17:64007812-64007819 | 8mer-1a | chr17:64007803-64007821 | 158.00 | -12.31 |
ROSMAP | ENST00000579687 | 64007741 | 64007822 | hsa-miR-3609 | chr17:64007812-64007819 | 8mer-1a | chr17:64007803-64007821 | 158.00 | -12.31 |
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SNVs in the skipped exons for ICAM2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ICAM2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ICAM2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ICAM2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ICAM2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ICAM2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |