Home Download Statistics Landscape Help Contact

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for TNC

Gene summary

Gene information	Gene symbol	TNC
	Gene ID	3371
	Gene name	tenascin C
	Synonyms	150-225|DFNA56|GMEM|GP|HXB|JI|TN|TN-C
	Cytomap	9q33.1
	Type of gene	protein-coding
	Description	tenascinGP 150-225cytotactindeafness, autosomal dominant 56glioma-associated-extracellular matrix antigenhexabrachion (tenascin)myotendinous antigenneuronectintenascin-C additional domain 1tenascin-C isoform 14/AD1/16
	Modification date	20200315
	UniProtAcc	A0A024R884, A0A0U1RR80, A7MBN2, A9YUB8, E9PC84, F5H5D6, F5H7V9, H0YGZ3, J3QSU6, P24821,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

Gene structures and expression levels for TNC

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000041982

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
PG	UP	3.500881e+02	9.922626e-01	2.881806e-09	2.214745e-07

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000350763.9	TNC-202:protein_coding:TNC	1.508312e+02	1.339483e+00	4.130409e-11	3.435456e-08
PG	UP	ENST00000341037.8	TNC-201:protein_coding:TNC	1.150182e+02	1.058990e+00	3.949444e-06	2.534763e-04
PG	UP	ENST00000423613.6	TNC-203:protein_coding:TNC	5.735655e+01	1.098687e+00	2.392898e-03	2.713144e-02
PG	UP	ENST00000481475.1	TNC-207:lncRNA:TNC	3.990540e+00	8.928015e-01	2.823874e-03	3.052105e-02
TC	UP	ENST00000544972.1	TNC-213:protein_coding:TNC	4.170289e+00	2.136382e+00	1.295817e-04	1.987150e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TNC

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_102793	chr9	115059855:115060002:115062917:115063189:115063796:115064068	115062917:115063189
exon_skip_12851	chr9	115090743:115091154:115115003:115115106:115117982:115118157	115115003:115115106
exon_skip_144366	chr9	115042219:115042341:115046410:115046682:115048260:115048532	115046410:115046682
exon_skip_144495	chr9	115046410:115046682:115048260:115048532:115057153:115057425	115048260:115048532
exon_skip_149956	chr9	115063796:115064068:115064647:115064919:115073603:115073641	115064647:115064919
exon_skip_169876	chr9	115059730:115060002:115062917:115063189:115063796:115064068	115062917:115063189
exon_skip_172913	chr9	115042219:115042341:115046410:115046682:115057153:115057425	115046410:115046682
exon_skip_75321	chr9	115046624:115046682:115048260:115048532:115057153:115057425	115048260:115048532

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for TNC

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000350763	115046410	115046682	In-frame
ENST00000350763	115048260	115048532	In-frame
ENST00000350763	115062917	115063189	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000350763	115048260	115048532	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000350763	115046410	115046682	In-frame
ENST00000350763	115048260	115048532	In-frame
ENST00000350763	115062917	115063189	In-frame
ENST00000350763	115064647	115064919	In-frame

Top

Infer the effects of exon skipping event on protein functional features for TNC

p-ENSG00000041982_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000350763	7658	2201	115062917	115063189	4173	4444	1253	1344
ENST00000350763	7658	2201	115048260	115048532	4992	5263	1526	1617
ENST00000350763	7658	2201	115046410	115046682	5265	5536	1617	1708

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000350763	7658	2201	115048260	115048532	4992	5263	1526	1617

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000350763	7658	2201	115064647	115064919	3627	3898	1071	1162
ENST00000350763	7658	2201	115064647	115064919	3627	3898	1071	1162
ENST00000350763	7658	2201	115062917	115063189	4173	4444	1253	1344
ENST00000350763	7658	2201	115048260	115048532	4992	5263	1526	1617
ENST00000350763	7658	2201	115046410	115046682	5265	5536	1617	1708

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P24821	1253	1344	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1253	1344	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1253	1344	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1253	1344	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1253	1344	1167	1256	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1253	1344	1258	1350	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1253	1344	1261	1261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1253	1344	1275	1275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P24821	1253	1344	1301	1301	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:18780401,PMID:19159218
P24821	1526	1617	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1526	1617	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1526	1617	1440	1531	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1617	1708	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1617	1708	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1617	1708	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1617	1708	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1617	1708	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1617	1708	1622	1711	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1617	1708	1677	1677	Natural variant	ID=VAR_060738;Note=I->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1704365,ECO:0000269|PubMed:1719530,ECO:0000269|PubMed:2466295,ECO:0000269|PubMed:7531707;Dbxref=dbSNP:rs2104772,PMID:1704365,PMID:1719530,PMI

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P24821	1526	1617	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1526	1617	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1526	1617	1440	1531	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P24821	1071	1162	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1071	1162	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1071	1162	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1071	1162	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1071	1162	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1071	1162	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1071	1162	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1071	1162	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1071	1162	991	1075	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1071	1162	991	1075	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1071	1162	1076	1165	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1071	1162	1076	1165	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1071	1162	1079	1079	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1071	1162	1079	1079	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1071	1162	1093	1093	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1071	1162	1093	1093	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1071	1162	1119	1119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P24821	1071	1162	1119	1119	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P24821	1253	1344	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1253	1344	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1253	1344	1072	1435	Alternative sequence	ID=VSP_001412;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1253	1344	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1253	1344	1167	1256	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1253	1344	1258	1350	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1253	1344	1261	1261	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18780401;Dbxref=PMID:18780401
P24821	1253	1344	1275	1275	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P24821	1253	1344	1301	1301	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18780401,ECO:0000269|PubMed:19159218;Dbxref=PMID:18780401,PMID:19159218
P24821	1526	1617	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1526	1617	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1526	1617	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1526	1617	1440	1531	Domain	Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1526	1617	1534	1534	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1526	1617	1600	1608	Sequence conflict	Note=SGFTQGHQT->LWLHPRASN;Ontology_term=ECO:0000305;evidence=ECO:0000305
P24821	1617	1708	1072	1708	Alternative sequence	ID=VSP_001415;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2466295;Dbxref=PMID:2466295
P24821	1617	1708	1072	1617	Alternative sequence	ID=VSP_001414;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1617	1708	1527	1617	Alternative sequence	ID=VSP_001413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1707164;Dbxref=PMID:1707164
P24821	1617	1708	23	2201	Chain	ID=PRO_0000007741;Note=Tenascin
P24821	1617	1708	1533	1621	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1617	1708	1622	1711	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
P24821	1617	1708	1677	1677	Natural variant	ID=VAR_060738;Note=I->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1704365,ECO:0000269|PubMed:1719530,ECO:0000269|PubMed:2466295,ECO:0000269|PubMed:7531707;Dbxref=dbSNP:rs2104772,PMID:1704365,PMID:1719530,PMI

Top

3'-UTR located exon skipping events that lost miRNA binding sites in TNC

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for TNC

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for TNC

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNC

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for TNC

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

Top

RelatedDrugs for TNC

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for TNC

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | Emergency Information |Site Policies