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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HSP90AB1 |
 Gene summary |
| Gene information | Gene symbol | HSP90AB1 | Gene ID | 3326 |
| Gene name | heat shock protein 90 alpha family class B member 1 | |
| Synonyms | D6S182|HSP84|HSP90B|HSPC2|HSPCB | |
| Cytomap | 6p21.1 | |
| Type of gene | protein-coding | |
| Description | heat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HSP90AB1 | GO:0007004 | telomere maintenance via telomerase | 10197982 |
| HSP90AB1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 24613385 |
| HSP90AB1 | GO:0031396 | regulation of protein ubiquitination | 16809764 |
| HSP90AB1 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 24613385 |
| HSP90AB1 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 26593036 |
| HSP90AB1 | GO:0051131 | chaperone-mediated protein complex assembly | 10811660 |
| HSP90AB1 | GO:0051973 | positive regulation of telomerase activity | 10197982 |
| HSP90AB1 | GO:1901389 | negative regulation of transforming growth factor beta activation | 20599762 |
| HSP90AB1 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
| HSP90AB1 | GO:2000010 | positive regulation of protein localization to cell surface | 23431407 |
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Gene structures and expression levels for HSP90AB1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000096384
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000371554.2 | HSP90AB1-202:protein_coding:HSP90AB1 | 6.338324e+01 | 8.380121e-01 | 5.226573e-04 | 2.766305e-02 |
| CB | UP | ENST00000371554.2 | HSP90AB1-202:protein_coding:HSP90AB1 | 2.009650e+02 | 9.190087e-01 | 4.157257e-07 | 7.120133e-06 |
| CB | UP | ENST00000353801.7 | HSP90AB1-201:protein_coding:HSP90AB1 | 4.221136e+02 | 8.106993e-01 | 2.740728e-04 | 1.737672e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HSP90AB1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_13296 | chr6 | 44251048:44251213:44251418:44251608:44251737:44251884 | 44251418:44251608 |
| exon_skip_223533 | chr6 | 44247101:44247195:44248617:44248776:44249377:44249583 | 44248617:44248776 |
| exon_skip_2391 | chr6 | 44247101:44247195:44248630:44248776:44249377:44249583 | 44248630:44248776 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HSP90AB1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353801 | 44248617 | 44248776 | 5CDS-5UTR |
| ENST00000353801 | 44251418 | 44251608 | Frame-shift |
| ENST00000371554 | 44251418 | 44251608 | Frame-shift |
| ENST00000371646 | 44251418 | 44251608 | Frame-shift |
| ENST00000620073 | 44251418 | 44251608 | Frame-shift |
| ENST00000371646 | 44248630 | 44248776 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353801 | 44248617 | 44248776 | 5CDS-5UTR |
| ENST00000371646 | 44248630 | 44248776 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353801 | 44248617 | 44248776 | 5CDS-5UTR |
| ENST00000353801 | 44251418 | 44251608 | Frame-shift |
| ENST00000371554 | 44251418 | 44251608 | Frame-shift |
| ENST00000371646 | 44251418 | 44251608 | Frame-shift |
| ENST00000620073 | 44251418 | 44251608 | Frame-shift |
| ENST00000371646 | 44248630 | 44248776 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HSP90AB1 |
p-ENSG00000096384_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371646 | 2589 | 724 | 44248630 | 44248776 | 111 | 256 | 0 | 49 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371646 | 2589 | 724 | 44248630 | 44248776 | 111 | 256 | 0 | 49 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371646 | 2589 | 724 | 44248630 | 44248776 | 111 | 256 | 0 | 49 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08238 | 0 | 49 | 11 | 16 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 46 | 46 | Binding site | Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P08238 | 0 | 49 | 2 | 724 | Chain | ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta |
| P08238 | 0 | 49 | 19 | 30 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 38 | 60 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 1 | 1 | Initiator methionine | Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2492519;Dbxref=PMID:2492519 |
| P08238 | 0 | 49 | 42 | 42 | Mutagenesis | Note=Strong ATP-binding. Strong interaction with HSF1%2C HIF1A%2C ERBB2%2C MET%2C KEAP1 and RHOBTB2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842 |
| P08238 | 0 | 49 | 2 | 527 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771 |
| P08238 | 0 | 49 | 2 | 214 | Region | Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457 |
| P08238 | 0 | 49 | 34 | 37 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCH |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08238 | 0 | 49 | 11 | 16 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 46 | 46 | Binding site | Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P08238 | 0 | 49 | 2 | 724 | Chain | ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta |
| P08238 | 0 | 49 | 19 | 30 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 38 | 60 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 1 | 1 | Initiator methionine | Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2492519;Dbxref=PMID:2492519 |
| P08238 | 0 | 49 | 42 | 42 | Mutagenesis | Note=Strong ATP-binding. Strong interaction with HSF1%2C HIF1A%2C ERBB2%2C MET%2C KEAP1 and RHOBTB2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842 |
| P08238 | 0 | 49 | 2 | 527 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771 |
| P08238 | 0 | 49 | 2 | 214 | Region | Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457 |
| P08238 | 0 | 49 | 34 | 37 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCH |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08238 | 0 | 49 | 11 | 16 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 46 | 46 | Binding site | Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P08238 | 0 | 49 | 2 | 724 | Chain | ID=PRO_0000062917;Note=Heat shock protein HSP 90-beta |
| P08238 | 0 | 49 | 19 | 30 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 38 | 60 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ |
| P08238 | 0 | 49 | 1 | 1 | Initiator methionine | Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2492519;Dbxref=PMID:2492519 |
| P08238 | 0 | 49 | 42 | 42 | Mutagenesis | Note=Strong ATP-binding. Strong interaction with HSF1%2C HIF1A%2C ERBB2%2C MET%2C KEAP1 and RHOBTB2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842 |
| P08238 | 0 | 49 | 2 | 527 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771 |
| P08238 | 0 | 49 | 2 | 214 | Region | Note=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457 |
| P08238 | 0 | 49 | 34 | 37 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCH |
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3'-UTR located exon skipping events that lost miRNA binding sites in HSP90AB1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for HSP90AB1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HSP90AB1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HSP90AB1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HSP90AB1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HSP90AB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HSP90AB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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