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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HSP90AA1 |
 Gene summary |
| Gene information | Gene symbol | HSP90AA1 | Gene ID | 3320 |
| Gene name | heat shock protein 90 alpha family class A member 1 | |
| Synonyms | EL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2 | |
| Cytomap | 14q32.31 | |
| Type of gene | protein-coding | |
| Description | heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock | |
| Modification date | 20200327 | |
| UniProtAcc | A0A0U1RR69, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HSP90AA1 | GO:0001934 | positive regulation of protein phosphorylation | 19363271 |
| HSP90AA1 | GO:0007004 | telomere maintenance via telomerase | 10197982 |
| HSP90AA1 | GO:0031396 | regulation of protein ubiquitination | 16809764 |
| HSP90AA1 | GO:0032273 | positive regulation of protein polymerization | 19363271 |
| HSP90AA1 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| HSP90AA1 | GO:0051131 | chaperone-mediated protein complex assembly | 15644312 |
| HSP90AA1 | GO:0051973 | positive regulation of telomerase activity | 10197982 |
| HSP90AA1 | GO:1902949 | positive regulation of tau-protein kinase activity | 19363271 |
| HSP90AA1 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
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Gene structures and expression levels for HSP90AA1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000080824
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| CB | UP | 8.300016e+04 | 9.109774e-01 | 1.069314e-07 | 1.582174e-06 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000555662.1 | HSP90AA1-205:retained_intron:HSP90AA1 | 1.377893e+01 | 1.219282e+00 | 9.109419e-04 | 3.646659e-02 |
| PG | UP | ENST00000560130.1 | HSP90AA1-210:retained_intron:HSP90AA1 | 3.523084e+01 | 1.070485e+00 | 6.724127e-05 | 2.049225e-03 |
| PG | UP | ENST00000556554.1 | HSP90AA1-206:retained_intron:HSP90AA1 | 6.225217e+01 | 9.595164e-01 | 1.245385e-04 | 3.229081e-03 |
| PG | UP | ENST00000557089.1 | HSP90AA1-207:retained_intron:HSP90AA1 | 7.178685e+01 | 9.060457e-01 | 2.108338e-04 | 4.738752e-03 |
| CB | UP | ENST00000560130.1 | HSP90AA1-210:retained_intron:HSP90AA1 | 4.353956e+01 | 2.426168e+00 | 7.713267e-15 | 2.839101e-12 |
| CB | UP | ENST00000554401.1 | HSP90AA1-204:nonsense_mediated_decay:HSP90AA1 | 4.816145e+02 | 1.662332e+00 | 1.341698e-11 | 1.243985e-09 |
| CB | UP | ENST00000555662.1 | HSP90AA1-205:retained_intron:HSP90AA1 | 2.009006e+01 | 1.861831e+00 | 2.506455e-09 | 9.409712e-08 |
| CB | UP | ENST00000557089.1 | HSP90AA1-207:retained_intron:HSP90AA1 | 7.348341e+01 | 1.480450e+00 | 2.629591e-09 | 9.814288e-08 |
| CB | UP | ENST00000558600.1 | HSP90AA1-209:protein_coding:HSP90AA1 | 1.647415e+01 | 8.995094e-01 | 4.980726e-09 | 1.677343e-07 |
| CB | UP | ENST00000556554.1 | HSP90AA1-206:retained_intron:HSP90AA1 | 3.893027e+01 | 1.392187e+00 | 1.163764e-07 | 2.415392e-06 |
| CB | UP | ENST00000216281.12 | HSP90AA1-201:protein_coding:HSP90AA1 | 7.681659e+04 | 8.234984e-01 | 1.750350e-06 | 2.413967e-05 |
| CB | UP | ENST00000553585.5 | HSP90AA1-203:protein_coding:HSP90AA1 | 6.115885e+00 | 1.093743e+00 | 6.057372e-04 | 3.392609e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HSP90AA1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_139342 | chr14 | 102085422:102085431:102085758:102086124:102086217:102086331 | 102085758:102086124 |
| exon_skip_147337 | chr14 | 102081809:102081821:102082111:102082444:102083034:102083302 | 102082111:102082444 |
| exon_skip_200522 | chr14 | 102086272:102086378:102101875:102102085:102139250:102139465 | 102101875:102102085 |
| exon_skip_204936 | chr14 | 102085422:102085431:102085965:102086124:102086217:102086331 | 102085965:102086124 |
| exon_skip_222367 | chr14 | 102085299:102085431:102085965:102086124:102086217:102086331 | 102085965:102086124 |
| exon_skip_249169 | chr14 | 102085410:102085431:102085758:102086124:102086217:102086331 | 102085758:102086124 |
| exon_skip_250429 | chr14 | 102086368:102086378:102101875:102102085:102139250:102139465 | 102101875:102102085 |
| exon_skip_257383 | chr14 | 102085298:102085431:102085965:102086124:102086217:102086331 | 102085965:102086124 |
| exon_skip_271369 | chr14 | 102085410:102085431:102085965:102086124:102086217:102086331 | 102085965:102086124 |
| exon_skip_292423 | chr14 | 102085298:102085431:102085758:102086124:102086217:102086331 | 102085758:102086124 |
| exon_skip_33543 | chr14 | 102086217:102086378:102101875:102102085:102139250:102139465 | 102101875:102102085 |
| exon_skip_71202 | chr14 | 102081049:102081821:102082111:102082444:102083034:102083302 | 102082111:102082444 |
| exon_skip_93023 | chr14 | 102085299:102085431:102085758:102086124:102086217:102086331 | 102085758:102086124 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HSP90AA1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216281 | 102082111 | 102082444 | Frame-shift |
| ENST00000216281 | 102085758 | 102086124 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216281 | 102085758 | 102086124 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216281 | 102082111 | 102082444 | Frame-shift |
| ENST00000216281 | 102085758 | 102086124 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for HSP90AA1 |
p-ENSG00000080824_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in HSP90AA1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for HSP90AA1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HSP90AA1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HSP90AA1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HSP90AA1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HSP90AA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P07900 | approved|investigational | DB00615 | Rifabutin | small molecule | P07900 |
| P07900 | approved|investigational | DB00716 | Nedocromil | small molecule | P07900 |
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RelatedDiseases for HSP90AA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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